An inventory of land use, Northwest, Omaha

Spatial growth has been a significant factor contributing to and resulting from the changing structure of American cities. This research project attempts to identify the spatial growth and the resulting land use patterns and areal associations of a portion of the dynamic growth area of Omaha, Nebraska

Regulation of Age-Related Protein Toxicity

Proteome damage plays a major role in aging and age-related neurodegenerative diseases. Under healthy conditions, molecular quality control mechanisms prevent toxic protein misfolding and aggregation. These mechanisms include molecular chaperones for protein folding, spatial compartmentalization for sequestration, and degradation pathways for the removal of harmful proteins. These mechanisms decline with age, resulting in the accumulation of aggregation-prone proteins that are harmful to cells. In the past decades, a variety of fast- and slow-aging model organisms have been used to investigate the biological mechanisms that accelerate or prevent such protein toxicity. In this review, we describe the most important mechanisms that are required for maintaining a healthy proteome. We describe how these mechanisms decline during aging and lead to toxic protein misassembly, aggregation, and amyloid formation. In addition, we discuss how optimized protein homeostasis mechanisms in long-living animals contribute to prolonging their lifespan. This knowledge might help us to develop interventions in the protein homeostasis network that delay aging and age-related pathologies

Regulation of protein homeostasis in neurodegenerative diseases:the role of coding and non-coding genes

Protein homeostasis is fundamental for cell function and survival, because proteins are involved in all aspects of cellular function, ranging from cell metabolism and cell division to the cell's response to environmental challenges. Protein homeostasis is tightly regulated by the synthesis, folding, trafficking and clearance of proteins, all of which act in an orchestrated manner to ensure proteome stability. The protein quality control system is enhanced by stress response pathways, which take action whenever the proteome is challenged by environmental or physiological stress. Aging, however, damages the proteome, and such proteome damage is thought to be associated with aging-related diseases. In this review, we discuss the different cellular processes that define the protein quality control system and focus on their role in protein conformational diseases. We highlight the power of using small organisms to model neurodegenerative diseases and how these models can be exploited to discover genetic modulators of protein aggregation and toxicity. We also link findings from small model organisms to the situation in higher organisms and describe how some of the genetic modifiers discovered in organisms such as worms are functionally conserved throughout evolution. Finally, we demonstrate that the non-coding genome also plays a role in maintaining protein homeostasis. In all, this review highlights the importance of protein and RNA homeostasis in neurodegenerative diseases

Synergies of Drell-Yan, top and beauty in global SMEFT fits

We present a global fit of Drell-Yan, top-quark and beauty-physics data in the Standard Model Effective Field Theory framework using the Minimal Flavor Violation ansatz for the quark-flavor structure. The different energy scales are thereby connected by applying the renormalization group equation and matching onto the Weak Effective Theory in order to incorporate $b\to s$ FCNCs at low energies into the fit. We find that the combination of the different sectors greatly improves the bounds on the Wilson coefficients.Comment: Talk at the 15th International Workshop on Top Quark Physics, Durham, UK, 4-9 September 202

Investigating the influence of water scarcity on the well being of some primary school learners in the Lubombo region of Swaziland.

Master of Education in Education Studies. University of KwaZulu-Natal, Durban 2017.This research was aimed at understanding some learners’ experiences of water scarcity and well-being in Thulwane primary school in the Lubombo region of Swaziland. A case study was carried out with the focus being on the learner’s experiences of water scarcity at primary school, how the scarcity of water influences the learner’s well-being and how these primary school learners are able to cope in times of water scarcity. The study employed a qualitative research design which used a grounded theory approach in order to understand learners’ experiences of water scarcity and the well-being of learners in a school context where there is limited water supply. The study was guided by the following main research question; what is the influence of water scarcity on the well-being of learners in Thulwane primary school in the Lubombo region of Swaziland? The following sub-questions guided the researcher: a) what are primary school learners’ experiences of water scarcity in Lubombo Region. b) How is water scarcity influencing primary school learners ‘well-being? c) How are the primary school learners coping with water scarcity? A questionnaire was administered to Grades 5 to 7, with biographic information that was used to sample 24 learners who participated in the interviews. A semi-structured interview was carried out with the 24 learners with different abilities. Data was collected from the 24 learners, was coded and analysed using content analysis, and then interpreted using the grounded theory. The findings of the study indicated that most learners’ experienced great scarcity of water in their schooling days and that created a number of challenges. The study also found that learners experienced challenges in terms of their health and hygiene and this affected the levels of medication while at school and the washing of their hands. The study revealed that water scarcity influences the well-being of learners, like their academic performance. The learners in the current study developed coping strategies such as bringing water from home. The implication of this study was that water scarcity interfered with the overall curriculum and extra-curricular activities

The Use of the Expanded Health Belief Model (EHBM) To Evaluate Osteoporosis Attitudes, Knowledge, Beliefs and Self Efficacy of Nez Perce Tribal and Non Nez Perce Tribal Members in Nez Perce County, ID

AN ABSTRACT OF THE DISSERTATION OF VICTOR NOLLEN WHITE, for the Doctor of Philosophy degree in Health Education, presented On November 14, 2014, at Southern Illinois University Carbondale. Title: THE USE OF THE EXPANDED HEALTH BELIEF MODEL (EHBM) TO EVALAUTE OSTEOPOROSIS ATTITUDES, KNOWLEDGE, BELIEFS AND SELF-EFFICACY OF NEZ PERCE TRIBAL AND NON NEZ PERCE TRIBAL MEMBERS IN NEZ PERCE COUNTY, IDAHO. Major Professor: Dr. Dhitinut Ratnapradipa According to the State of Idaho, the National Osteoporosis Foundation, and the U.S. Department of Health and Human Services, osteoporosis is a public health concern nationally among non-Native American (NNA) and Native American (NA) populations. The purpose of this research project is to obtain written survey data on osteoporosis attitudes, knowledge, beliefs, and self-efficacy among male and female members of the Nez Perce Tribe (Nimiipuu) and non-Tribal members, aged 18 and over via voluntary completion of a written survey questionnaire based on the expanded health belief model (EHBM). The study was conducted in Nez Perce County, ID. The research involved determining whether or not there is a statistically significant difference in osteoporosis attitudes, knowledge, beliefs and self-efficacy among males and females, aged 18 and over Nez Perce Tribal members as compared to Non-Tribal members in Nez Perce County, ID. Non-Nez Perce tribal members are individuals whom are 1) Native Americans who are not members of the Nez Perce Tribe and 2) all Non-Native Americans in the research study. Exercise self-efficacy and gender seem to be the most significant variables showing evidence against the null hypotheses and in favor of the research hypothesis (Null Hypothesis: H0: Native American=Non-Native American. Research Hypothesis: H1: Native American ≠ Non-Native American). Age also shows evidence against the null hypothesis and in favor of the research hypothesis, but not as strongly as exercise and gender. Seriousness of osteoporosis was the most concern to all respondents and female Native Americans perceived the greatest barrier to preventing osteoporosis was being unable to access dietary calcium on a regular basis