成人女性の常温と寒冷における体温調節反応の比較

The purpose of this study was to observe the differences of thermoregulatory responses between normal condition (24℃RH 50%) and cold temperature condition (-30℃). Subjects were 18 healthy Japanese adult women (age : 21.5±1.1 yrs, stature : 158.9±3.3 cm, weight : 52.3±8.0 kg, fat% : 25.7±4.4%). The clothing conditions were 0.18 clo for normal condition and 2.0 clo for cold condition. The exposure time was 40 minutes for the first normal condition, 20 minutes for cold condition and 40 minutes for the second normal condition. The subjects kept a sitting position. Measurement items were rectal temperature, skin temperature, oxygen uptake and subjective sensations. We determined atsugari (susceptibility to the heat) and samugari (susceptibility to the cold) according to the subjective sensations during the first normal condition exposure. The grouping of atsugari and samugari did not always agree with the self-reported atsugari and samugari of each subject. The atsugari group had a tendency to show high peripheral skin temperature, low rectal temperature and warmer thermal sensation than samugari group. However, it was not significant. Oxygen uptake was significantly higher (p<0.05) in samugari group than atsugari group

日本人成人女性の化粧におけるプロセスと効果

実験の被験者は19～25歳(平均21.6歳)の健康な日本人成人女性18名であった。まず調査用紙に記入させ、洗顔と化粧を行わせた。測定項目は、化粧のプロセス、皮膚色、皮膚水分量、皮膚の湿皮脂量および睫毛長であった。被験者が使用した化粧品や化粧の所要時間は様々であったが、順序は全被験者間で同様となった。化粧により、睫毛は長くなったが、曲率は必ずしも増加しなかった。頬部については、皮脂量は減り、色彩は赤みを増した。本研究を通じ、目は化粧のプロセスにおいて、所要時間にせよ色彩にせよ特別の位置を占めていることが確認された。The subjects were 18 Japanese adult females 19 to 25 years old (21.6yrs±1.4). In the first place, they washed their face. Secondly, they made themselves up on the assumption that they participate in the party. They were instructed to prepare their own cosmetics. The measurement items were the changes of skin color, sebaceous matter, configuration of eyelashes and process of makeup. The processes of makeup were recorded by themselves. The makeup gave a health impression, extended eyelashes by 1.1mm and increased the degree of curvature of eyelashes. The time required of makeup was 10 to 62 min, and the number of processes was 5 to 19. However, the procedure of makeup was definite. Namely, the subjects treated their eye in the first and lips in the last

« Uluus ».The first médecine with a western-styled name in Japan / (« Uluus », Le premier médicament nommé à l'européenne au Japon)

Iwai Kojiro, Nojiri Kayoko, Aoki Nobuo. « Uluus ».The first médecine with a western-styled name in Japan / (« Uluus », Le premier médicament nommé à l'européenne au Japon). In: Revue d'histoire de la pharmacie, 84ᵉ année, n°312, 1996. Actes du XXXIe Congrès International d'Histoire de la Pharmacie (Paris, 25-29 septembre 1995) p. 378

« Uluus ».The first médecine with a western-styled name in Japan / (« Uluus », Le premier médicament nommé à l'européenne au Japon)

Iwai Kojiro, Nojiri Kayoko, Aoki Nobuo. « Uluus ».The first médecine with a western-styled name in Japan / (« Uluus », Le premier médicament nommé à l'européenne au Japon). In: Revue d'histoire de la pharmacie, 84ᵉ année, n°312, 1996. Actes du XXXIe Congrès International d'Histoire de la Pharmacie (Paris, 25-29 septembre 1995) p. 378

Characterization of hepatitis B virus with complex structural variations

Abstract Background Hepatitis B virus (HBV) infection is one of the most serious public health issues. Recent HBV genetic research has revealed novel genetic rearrangements termed complex structural variations (SVs), which are composed of combinations of SVs such as insertions, deletions, and duplications. An extensive search was made for complex SVs of HBV and their characteristics were analyzed. Results Fifty-five HBV strains with complex SVs were identified by analyzing genetic sequences of HBV with bioinformatical tools. Along with 15 HBV strains with complex SVs in a previous report, a total of 70 HBV strains harboring complex SVs were analyzed. Complex SVs in the HBV genome were located frequently between nt 1500 and 2000. Insertions were observed in 65/70 (92.9%) of HBV strains with complex SVs. As insertional motif sequences, hepatocyte nuclear factor 1 binding site, a sequence complementary to part of box α in enhancer II, and insertions of unknown origins were observed. The complex SVs were classified into six groups, and combination of insertion and deletion was observed more frequently than other patterns. Conclusion Through an extensive search of HBV sequences, new strains with complex SVs were identified in this study. Characteristics of HBV with complex SVs were clarified by the analysis of 70 HBV strains harboring complex SVs. Further investigation is required to elucidate its role in pathogenesis of HBV-related liver disease

Serum CXCL10 levels at the start of the second course of atezolizumab plus bevacizumab therapy predict therapeutic efficacy in patients with advanced BCLC stage C hepatocellular carcinoma: A multicenter analysis

Abstract Background & Aims Relationships of serum C‐C motif chemokine ligand 5 (CCL5) and C‐X‐C motif chemokine ligand 10 (CXCL10) levels with hot immune features have been reported in patients with hepatocellular carcinoma (HCC). Therefore, we examined the utility of their levels for predicting the efficacy of atezolizumab plus bevacizumab (Atez/Bev) in patients with HCC. Design In total, 98 patients with HCC treated with Atez/Bev were enrolled, and their initial responses were evaluated at least once via dynamic computed tomography or magnetic resonance imaging. Serum CCL5 and CXCL10 levels were assessed by enzyme‐linked immunosorbent assay before treatment and at the start of the second course of Atez/Bev therapy, and their relationships with treatment efficacy were determined. Results No analyzed factor was associated with the initial therapeutic response. Among the 56 patients with Barcelona Clinic Liver Cancer (BCLC) stage C, serum CXCL10 levels at the beginning of course two (CXCL10‐2c) tended to be higher in responders than in non‐responders in the initial evaluation, and its optimal cutoff level of 690 pg/mL could be used to stratify patients regarding overall survival (OS; high vs. low: not reached vs. 17.6 months, p = 0.034) and progression‐free survival (high vs. low: 13.6 vs. 5.1 months, p = 0.014). In multivariate analysis, high CXCL10 levels and neutrophil‐to‐lymphocyte ratios at the start of course two and Child–Pugh stage A at baseline were independent predictive factors of improved OS. Conclusions Serum CXCL10‐2c levels were predictive of Atez/Bev efficacy in patients with BCLC stage C HCC