252 research outputs found
Sphalerons, spectral flow, and anomalies
The topology of configuration space may be responsible in part for the
existence of sphalerons. Here, sphalerons are defined to be static but unstable
finite-energy solutions of the classical field equations. Another manifestation
of the nontrivial topology of configuration space is the phenomenon of spectral
flow for the eigenvalues of the Dirac Hamiltonian. The spectral flow, in turn,
is related to the possible existence of anomalies. In this review, the
interconnection of these topics is illustrated for three particular sphalerons
of SU(2) Yang-Mills-Higgs theory.Comment: 35 pages with revtex4; invited paper for the August special issue of
JMP on "Integrability, topological solitons and beyond
Wear of human teeth: a tribological perspective
The four main types of wear in teeth are attrition (enamel-on-enamel contact), abrasion (wear due to abrasive particles in food or toothpaste), abfraction (cracking in enamel and subsequent material loss), and erosion (chemical decomposition of the tooth). They occur as a result of a number of mechanisms including thegosis (sliding of teeth into their lateral position), bruxism (tooth grinding), mastication (chewing), toothbrushing, tooth flexure, and chemical effects. In this paper the current understanding of wear of enamel and dentine in teeth is reviewed in terms of these mechanisms and the major influencing factors are examined. In vitro tooth wear simulation and in vivo wear measurement and ranking are also discussed
Level Crossing Along Sphaleron Barriers
In the electroweak sector of the standard model topologically inequivalent
vacua are separated by finite energy barriers, whose height is given by the
sphale\-ron. For large values of the Higgs mass there exist several sphaleron
solutions and the barriers are no longer symmetric. We construct paths of
classical configurations from one vacuum to a neighbouring one and solve the
fermion equations in the background field configurations along such paths,
choosing the fermions of a doublet degenerate in mass. As in the case of light
Higgs masses we observe the level crossing phenomenon also for large Higgs
masses.Comment: 17 pages, latex, 10 figures in uuencoded postscript files. THU-94/0
The Sphaleron Barrier in the Presence of Fermions
We calculate the minimal energy path over the sphaleron barrier in the
pre\-sen\-ce of fermions, assuming that the fermions of a doublet are
degenerate in mass. This allows for spherically symmetric ans\"atze for the
fields, when the mixing angle dependence is neglected. While light fermions
have little influence on the barrier, the presence of heavy fermions ( TeV) strongly deforms the barrier, giving rise to additional sphalerons
for very heavy fermions ( 10 TeV). Heavy fermions form
non-topological solitons in the vacuum sector.Comment: 19 pages, latex, 18 figures in 3 seperate uuencoded postscript files
THU-93/1
Nondegenerate Fermions in the Background of the Sphaleron Barrier
We consider level crossing in the background of the sphaleron barrier for
nondegenerate fermions. The mass splitting within the fermion doublets allows
only for an axially symmetric ansatz for the fermion fields. In the background
of the sphaleron we solve the partial differential equations for the fermion
functions. We find little angular dependence for our choice of ansatz. We
therefore propose a good approximate ansatz with radial functions only. We
generalize this approximate ansatz with radial functions only to fermions in
the background of the sphaleron barrier and argue, that it is a good
approximation there, too.Comment: LATEX, 20 pages, 11 figure
Gradient Approach to the Sphaleron Barrier
We apply the gradient approach to obtain a path over the sphaleron barrier
and to demonstrate the fermionic level crossing phenomenon. Neglecting the
mixing angle dependence and assuming that the fermions of a doublet are
degenerate in mass we employ spherically symmetric ans\"atze for the fields.
The gradient path over the barrier is smooth, even for large values of the
Higgs boson mass or of the fermion mass, where the extremal energy path
bifurcates.Comment: 20 pages, latex, 13 figures in uuencoded postscript files. THU-94/1
Characterisation and Skin Distribution of Lecithin-Based Coenzyme Q10-Loaded Lipid Nanocapsules
The purpose of this study was to investigate the influence of the inner lipid ratio on the physicochemical properties and skin targeting of surfactant-free lecithin-based coenzyme Q10-loaded lipid nanocapsules (CoQ10-LNCs). The smaller particle size of CoQ10-LNCs was achieved by high pressure and a lower ratio of CoQ10/GTCC (Caprylic/capric triglyceride); however, the zeta potential of CoQ10-LNCs was above /− 60 mV/ with no distinct difference among them at different ratios of CoQ10/GTCC. Both the crystallisation point and the index decreased with the decreasing ratio of CoQ10/GTCC and smaller particle size; interestingly, the supercooled state of CoQ10-LNCs was observed at particle size below about 200 nm, as verified by differential scanning calorimetry (DSC) in one heating–cooling cycle. The lecithin monolayer sphere structure of CoQ10-LNCs was investigated by cryogenic transmission electron microscopy (Cryo-TEM). The skin penetration results revealed that the distribution of Nile red-loaded CoQ10-LNCs depended on the ratio of inner CoQ10/GTCC; moreover, epidermal targeting and superficial dermal targeting were achieved by the CoQ10-LNCs application. The highest fluorescence response was observed at a ratio of inner CoQ10/GTCC of 1:1. These observations suggest that lecithin-based LNCs could be used as a promising topical delivery vehicle for lipophilic compounds
Spectral flow of chiral fermions in nondissipative Yang-Mills gauge field backgrounds
Real-time anomalous fermion number violation is investigated for massless
chiral fermions in spherically symmetric SU(2) Yang-Mills gauge field
backgrounds which can be weakly dissipative or even nondissipative. Restricting
consideration to spherically symmetric fermion fields, the zero-eigenvalue
equation of the time-dependent effective Dirac Hamiltonian is studied in
detail. For generic spherically symmetric SU(2) gauge fields in Minkowski
spacetime, a relation is presented between the spectral flow and two
characteristics of the background gauge field. These characteristics are the
well-known ``winding factor,'' which is defined to be the change of the
Chern-Simons number of the associated vacuum sector of the background gauge
field, and a new ``twist factor,'' which can be obtained from the
zero-eigenvalue equation of the effective Dirac Hamiltonian but is entirely
determined by the background gauge field. For a particular class of (weakly
dissipative) Luscher-Schechter gauge field solutions, the level crossings are
calculated directly and nontrivial contributions to the spectral flow from both
the winding factor and the twist factor are observed. The general result for
the spectral flow may be relevant to electroweak baryon number violation in the
early universe.Comment: REVTeX, 43 pages, v4: final versio
Brain iron accumulation in unexplained fetal and infant death victims with smoker mothers-The possible involvement of maternal methemoglobinemia
<p>Abstract</p> <p>Background</p> <p>Iron is involved in important vital functions as an essential component of the oxygen-transporting heme mechanism. In this study we aimed to evaluate whether oxidative metabolites from maternal cigarette smoke could affect iron homeostasis in the brain of victims of sudden unexplained fetal and infant death, maybe through the induction of maternal hemoglobin damage, such as in case of methemoglobinemia.</p> <p>Methods</p> <p>Histochemical investigations by Prussian blue reaction were made on brain nonheme ferric iron deposits, gaining detailed data on their localization in the brainstem and cerebellum of victims of sudden death and controls. The Gless and Marsland's modification of Bielschowsky's was used to identify neuronal cell bodies and neurofilaments.</p> <p>Results</p> <p>Our approach highlighted accumulations of blue granulations, indicative of iron positive reactions, in the brainstem and cerebellum of 33% of victims of sudden death and in none of the control group. The modified Bielschowsky's method confirmed that the cells with iron accumulations were neuronal cells.</p> <p>Conclusions</p> <p>We propose that the free iron deposition in the brain of sudden fetal and infant death victims could be a catabolic product of maternal methemoglobinemia, a biomarker of oxidative stress likely due to nicotine absorption.</p
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