Planning for coal power plant transition : lessons learned from communities in Massachusetts

Thesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 2013.Cataloged from PDF version of thesis.Includes bibliographical references (p. 86-93).As coal-fired power plants across the U.S. are retiring in increasing numbers - a trend likely to continue in the years ahead - the communities that host these plants will play a critical role in balancing local concerns about public health, tax revenue, jobs and economic development with broader issues of fossil fuel dependence and climate change. This thesis investigates how three municipalities in Massachusetts are planning around the potential reuse and redevelopment of their coal plant sites. How are different stakeholder interests being convened and working together in these communities? What kinds of processes for public engagement are in place? Are these stakeholder and public engagement processes leading to politically viable outcomes? This thesis finds that active engagement of government officials, diverse and inclusive stakeholder tables, clear opportunities for public engagement and provision of adequate resources are all critical to credible, effective and sustained community processes around coal transition planning. Coal communities in Massachusetts vary in the extent to which they meet these criteria, but none of them are currently maximizing the potential for collaborative problem-solving around coal plant reuse. I conclude that consensus building presents a promising approach by which these municipalities might develop collective visions for coal plant reuse and create clear and actionable pathways towards sustainable redevelopment.by Aditya Kumar Nochur.M.C.P

Enzymatic desulfurization of coal

Our experimental approach focuses on the use of enzymes which catalyze the addition of oxygen to organic compounds., In tailoring the application of these enzymes to coal processing, we are particularly interested in ensuring that oxidation occurs at sulfur and not at carbon-carbon bonds. Previous studies with DBT have shown that the reaction most frequently observed in microbial oxidative pathways is one in which DBT is oxidized at ring carbons. These reactions, as we have said, are accompanied by a considerable decrease in the energy content of the compound. In addition, microbial pathways have been identified in which the sulfur atom is sequentially oxidized to sulfoxide, to sulfone, to sulfonate, and finally to sulfuric acid. In this case, the fuel value of the desulfurized compounds is largely retained. We are evaluating the potential of commercially available enzymes to perform this function

Design engineers and technical professionals at work: Observing information usage in the workplace

This exploratory study examines how design engineers and technical professionals (hereafter referred to as engineers) in innovative high-tech firms in the United States and India use information in their daily work activities including research, development, and management. The researchers used naturalistic observation to conduct a series of daylong workplace observations with 103 engineers engaged in product design and testing in four U.S.- and two India-based firms. A key finding is that engineers spend about one fourth of their day engaged in some type of information event, which was somewhat lower than the percentage identified in previous research. The explanation may be rooted in the significant change in the information environment and corporate expectations in the last 15 years, which is the time of the original study. Searching technology has improved, making searching less time consuming, and engineers are choosing the Internet as a primary source even though information may not be as focused, as timely, or as authoritative. The study extends our understanding of the engineering workplace, and the information environment in the workplace, and provides information useful for improving methods for accessing and using information, which could ultimately lead to better job performance, facilitate innovation, and encourage economic growth

Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis

BACKGROUND Patisiran, an investigational RNA interference therapeutic agent, specifically inhibits hepatic synthesis of transthyretin. METHODS In this phase 3 trial, we randomly assigned patients with hereditary transthyretin amyloidosis with polyneuropathy, in a 2:1 ratio, to receive intravenous patisiran (0.3 mg per kilogram of body weight) or placebo once every 3 weeks. The primary end point was the change from baseline in the modified Neuropathy Impairment Score+7 (mNIS+7; range, 0 to 304, with higher scores indicating more impairment) at 18 months. Other assessments included the Norfolk Quality of Life-Diabetic Neuropathy (Norfolk QOL-DN) questionnaire (range, −4 to 136, with higher scores indicating worse quality of life), 10-m walk test (with gait speed measured in meters per second), and modified body-mass index (modified BMI, defined as [weight in kilograms divided by square of height in meters]×albumin level in grams per liter; lower values indicated worse nutritional status). RESULTS A total of 225 patients underwent randomization (148 to the patisiran group and 77 to the placebo group). The mean (±SD) mNIS+7 at baseline was 80.9±41.5 in the patisiran group and 74.6±37.0 in the placebo group; the least-squares mean (±SE) change from baseline was −6.0±1.7 versus 28.0±2.6 (difference, −34.0 points; P<0.001) at 18 months. The mean (±SD) baseline Norfolk QOL-DN score was 59.6±28.2 in the patisiran group and 55.5±24.3 in the placebo group; the least-squares mean (±SE) change from baseline was −6.7±1.8 versus 14.4±2.7 (difference, −21.1 points; P<0.001) at 18 months. Patisiran also showed an effect on gait speed and modified BMI. At 18 months, the least-squares mean change from baseline in gait speed was 0.08±0.02 m per second with patisiran versus −0.24±0.04 m per second with placebo (difference, 0.31 m per second; P<0.001), and the least-squares mean change from baseline in the modified BMI was −3.7±9.6 versus −119.4±14.5 (difference, 115.7; P<0.001). Approximately 20% of the patients who received patisiran and 10% of those who received placebo had mild or moderate infusion-related reactions; the overall incidence and types of adverse events were similar in the two groups. CONCLUSIONS In this trial, patisiran improved multiple clinical manifestations of hereditary transthyretin amyloidosis

Executing Innovation

ix, 95 hlm, 18 c

DESIGN AND OPTIMIZATION OF VENTURI SCRUBBERS

Master'sMASTER OF ENGINEERIN

Enzymatic desulfurization of coal

The overall objective of this program was to investigate the feasibility of an enzymatic desulfurization process specifically intended for organic sulfur removal from coal. Toward that end, a series of specific objectives were defined: (1) establish the feasibility of (bio)oxidative pretreatment followed by biochemical sulfate cleavage for representative sulfur-containing model compounds and coals using commercially-available enzymes; (2) investigate the potential for the isolation and selective use of enzyme preparations from coal-utilizing microbial systems for desulfurization of sulfur-containing model compounds and coals; and (3) develop a conceptual design and economic analysis of a process for enzymatic removal of organic sulfur from coal. Within the scope of this program, it was proposed to carry out a portion of each of these efforts concurrently. (VC