13 research outputs found
Impact of frailty on long-term mortality in older patients receiving intensive care via the emergency department
- Author
- Aita Kaoruko
- Harada Masahiro
- Inaba Mototaka
- Ishihara Satoshi
- Ishikawa Hideki
- Kohama Keisuke
- Maeyama Hiroki
- Mayumi Toshihiko
- Muramatsu Shun
- Naito Hiromichi
- Nakamichi Chikaaki
- Nakao Atsunori
- Nozaki Satoshi
- Ohtsuka Tsuyoshi
- Sakurai Ryota
- Sato Shuho
- Shime Nobuaki
- Takaoka Makoto
- the LIFE Study Investigators
- Uemori Sadayori
- Yamashita Kazunori
- Yorifuji Takashi
- Publication venue
- nature portfolio
- Publication date
- 03/04/2023
- Field of study
The aim of this study was to evaluate whether frailty was associated with 6-month mortality in older adults who were admitted to the intensive care unit (ICU) with an illness requiring emergency care. The investigation was a prospective, multi-center, observational study conducted among the ICUs of 17 participating hospitals. Patients >= 65 years of age who were admitted to the ICU directly from an emergency department visit were assessed to determine their baseline Clinical Frailty Scale (CFS) scores before the illness and were surveyed 6 months after admission. Among 650 patients included in the study, the median age was 79 years old, and overall mortality at 6 months was as low as 21%, ranging from 6.2% in patients with CFS 1 to 42.9% in patients with CFS >= 7. When adjusted for potential confounders, CFS score was an independent prognostic factor for mortality (one-point increase in CFS, adjusted risk ratio with 95% confidence interval 1.19 [1.09-1.30]). Quality of life 6 months after admission worsened as baseline CFS score increased. However, there was no association between total hospitalization cost and baseline CFS. CFS is an important predictor of long-term outcomes among critically ill older patients requiring emergent admission
DOCK2 is involved in the host genetics and biology of severe COVID-19
- Author
- Abe Ryuzo
- Abe Shinji
- Adachi Tomohiro
- Adachi Yuichi
- Ai Masumi
- Amishima Masaru
- Amiya Saori
- Anan Ryusuke
- Ando Akira
- Anzai Tatsuhiko
- Aoki Ryousuke
- Arai Daisuke
- Arai Ryosuke
- Arai Sawako
- Arakawa Kenichi
- Arimura Ken
- Asai Satoshi
- Asakura Takanori
- Asano Koichiro
- Awano Nobuyasu
- Azekawa Shuhei
- Azuma Masanori
- Baba Hiroaki
- Baba Rie
- Baba Tomoya
- Beppu Satoru
- Chiba Shigeru
- Chihara Yusuke
- Chubachi Shotaro
- Edahiro Ryuya
- Egi Moritoki
- Eguchi Hirotaka
- Endo Akifumi
- Endo Mayu
- Enomoto Takatoshi
- Eriguchi Yoshihiro
- Fuchimoto Yasuko
- Fujii Kazuhiko
- Fujimoto Nobukazu
- Fujita Kazue
- Fujitani Shigeki
- Fujiwara Akiko
- Fuke Satoshi
- Fukui Takahiro
- Fukui Yasutaka
- Fukui Yoshinori
- Fukunaga Koichi
- Fukushima Munehisa
- Fukusumi Takahito
- Fukuta Tetsuya
- Fukuyama Satoru
- Funatsu Yohei
- Furukawa Yoichi
- Gon Yasuhiro
- Hagihara Masao
- Hagimoto Satoshi
- Hagiwara Eri
- Hagiwara Shigehiro
- Hamamoto Junko
- Hanada Satoko
- Hara Reina
- Harada Masahiro
- Harada Norihiro
- Harada Sonoko
- Harada Yuko
- Haruta Yuki
- Hase Isano
- Hasegawa Naoki
- Hasegawa Takanori
- Hasegawa Yoshinori
- Hashiguchi Mizuha
- Hashimoto Naozumi
- Hashimoto Satoru
- Hashino Takuya
- Hattori Takeshi
- Hayashi Hiroyuki
- Hayashi Kentaro
- Hayashi Reina
- Hayashi Shinichi
- Hida Naoya
- Higashiyama Masahiko
- Hiki Makoto
- Hirai Yoshihiro
- Hiramatsu Yuji
- Hirano Toshiyuki
- Hiranuma Hisato
- Hirata Haruhiko
- Hirouchi Takatomo
- Hizawa Nobuyuki
- Honda Takayuki
- Horinouchi Hirohisa
- Hoshino Kota
- Hosoda Chiaki
- Hyugaji Takayoshi
- Ichikado Kazuya
- Ichimura Naoya
- Igarashi Akira
- Ihara Shoichi
- Ikemura Shinnosuke
- Imai Takao
- Imamura Tomonori
- Imoto Seiya
- Inohara Hidenori
- Inomata Minoru
- Inoue Sumito
- Inoue Takashi
- Inoue Takuya
- Inoue Yoshiaki
- Ishiguro Takashi
- Ishihara Rino
- Ishihara Sayoko
- Ishihara Shoichiro
- Ishii Makoto
- Ishii Tomoo
- Ishikawa Motonao
- Ishikura Hiroyasu
- Ishioka Kota
- Isogai Susumu
- Isono Taisuke
- Ito Akihiro
- Ito Fumimaro
- Ito Kazuto
- Ito Satoshi
- Ito Yoko
- Iwagoe Hajime
- Iwamura Hiromu
- Izumi Namiki
- Izumo Takehiro
- Kabata Hiroki
- Kagaya Takashi
- Kagyo Junko
- Kai Hirayasu
- Kamata Hirofumi
- Kamatani Yoichiro
- Kamimaki Isamu
- Kamiya Akane
- Kan-o Keiko
- Kanai Masahiro
- Kanai Masayuki
- Kanai Takanori
- Kanaoka Kensuke
- Kanayama Syuji
- Kanda Hidenori
- Kanehiro Arihiko
- Kaneko Yutaro
- Kaneyama Yasunari
- Kasamatsu Yu
- Kashiwada Takeru
- Katayama Kazuhiko
- Katayama Kotoe
- Kato Kazuto
- Kato Yasuhiro
- Kawabata Shuhei
- Kawada Miki
- Kawamura Kodai
- Kawamura Yusuke
- Kawana Akihiko
- Kawana Masatoshi
- Kawashima Hidetoshi
- Kijima Noriyuki
- Kikuchi Ryota
- Kimizuka Yoshifumi
- Kimura Akinori
- Kimura Nozomu
- Kimura Tomoki
- Kimura Tomoyuki
- Kimura Yasuhiro
- Kishi Hiroto
- Kishikawa Toshihiro
- Kishima Haruhiko
- Kita Toshiyuki
- Kitagawa Yuichiro
- Kitagawa Yuko
- Kitamura Hideya
- Kobayashi Keigo
- Kobayashi Yoichi
- Kodaka Norio
- Kodama Nobuhiro
- Koh Hidefumi
- Kohashi Sumiko
- Koike Ryuji
- Koji Sakamoto
- Kojima Mitsuaki
- Kokuto Hiroyuki
- Komase Yuko
- Komuta Kiyoshi
- Konishi Shunichiro
- Kono Yuta
- Koretsune Yukihiro
- Koshida Kiyoshi
- Kozu Yutaka
- Kuge Tomoki
- Kumanogoh Atsushi
- Kuraki Takashige
- Kuramochi Mizuki
- Kurihara Yuko
- Kusaka Yu
- Kuse Naoyuki
- Kuwahara Naota
- Lee Ho
- Liu Yu-Chen
- Maeda Shunsuke
- Maeda Yuichi
- Maeno Toshitaka
- Makino Shohei
- Makino Yasushi
- Manabe Tadashi
- Maruyama Junichi
- Maruyama Shuhei
- Masaki Katsunori
- Mashimo Shuko
- Masuda Makoto
- Masumoto Akihide
- Masuzawa Keita
- Matsubara Yuta
- Matsuda Fumihiko
- Matsuda Koichi
- Matsui Yuma
- Matsumoto Kinnosuke
- Matsumoto Koichiro
- Matsumoto Shuichiro
- Matsumoto Takemasa
- Matsunaga Tomohiro
- Matsuo Hirotaka
- Matsuse Hiroto
- Matsushita Yasushi
- Mikami Yohei
- Minami Shiro
- Minemura Hiroyuki
- Mitamura Keiko
- Miyagawa Kazuya
- Miyake Takahito
- Miyano Satoru
- Miyawaki Masayoshi
- Miyawaki Satoru
- Miyazaki Masatoshi
- Miyazaki Yasunari
- Miyazaki Yoshimune
- Miyazawa Naoki
- Mochimaru Takao
- Mori Nobuaki
- Morikawa Daiki
- Morisaki Hiroshi
- Morisaki Takayuki
- Morita Atsuho
- Morita Takayoshi
- Motegi Mitsuru
- Motooka Daisuke
- Murakami Koji
- Murakami Teruaki
- Murakami Yoshinori
- Muranaka Hiroyuki
- Murayama Shigeo
- Murohashi Kota
- Muto Kaori
- Mutoh Yoshikazu
- Nagai Akiko
- Nagai Hideaki
- Nagao Genta
- Nagasaka Tomoki
- Nagasaki Tadao
- Nagasaki Yoji
- Nagata Kaoru
- Nagayama Satoshi
- Naito Tatsuhiko
- Naito Toshio
- Naito Yoko
- Nakachi Ichiro
- Nakada Taka-Aki
- Nakajima Jun
- Nakajima Yukiko
- Nakamori Yasushi
- Nakamura Ai
- Nakamura Kazunori
- Nakamura Morio
- Nakamura Yoshihiko
- Nakano Chihiro
- Nakano Yasushi
- Nakatsumi Hiroki
- Nakayama Akiyoshi
- Nakayama Sohei
- Namba Shinichi
- Namkoong Ho
- Nanki Kosaku
- Nannya Yasuhito
- Narita Atsuya
- Narumoto Osamu
- Nii Takuro
- Niitsu Takayuki
- Nikaido Takefumi
- Nishi Koichi
- Nishida Takashi
- Nishihara Hiroshi
- Nishikawa Masanori
- Nishimura Tomoyasu
- Nishio Kazumi
- Nishitsuji Masaru
- Nishiyama Kei
- Nishiyama Kenta
- Niwa Kazuki
- Noda Yoshimi
- Noguchi Yoichiro
- Nukaga Shigenari
- Obara Wataru
- Obata Daisuke
- Ochi Junichi
- Odani Toshio
- Odate Mitsuru
- Ogata Hideo
- Ogata Tomouki
- Ogawa Aki
- Ogawa Seishi
- Ogawa Shinichi
- Oguma Tsuyoshi
- Ogura Shinji
- Ogura Takashi
- Ogura Takayuki
- Ohba Takehiko
- Ohira Yoshiyuki
- Ohta Kazuhide
- Ohta Ken
- Ohta Shin
- Okabayashi Hiroko
- Okada Takenori
- Okada Yukinori
- Okamori Satoshi
- Okamoto Masaki
- Okudela Koji
- Okuzaki Daisuke
- Omae Yosuke
- Omote Norihito
- Ono Akihiro
- Ono Hiroshi
- Ono Yoshinao
- Onoi Keisuke
- Ooshima Nobuharu
- Osawa Takeshi
- Oshima Taku
- Oshio Takeshi
- Ota Sho
- Oyama Baku
- Oyamada Yoshitaka
- Ozaki Shinji
- Sado Reiko
- Sado Toshikatsu
- Sagara Hironori
- Sageshima Hisako
- Saiki Ryunosuke
- Saito Fukuki
- Saito Fumitake
- Saito Hiroshi
- Saito Ryuichi
- Saito Yoshinobu
- Sakagami Satoru
- Sakakibara Shuhei
- Sakurai Toshihiro
- Sano Hirohito
- Sano Tomoya
- Sasa Noah
- Sasaki Junichi
- Sasaki Kana
- Sasano Hajime
- Sasano Hitoshi
- Sassa Chihiro Tani
- Sato Masamichi
- Sato Ryuichi
- Sato Tomonori
- Sato Toshiro
- Sato Yoko
- Sato Yuki
- Satomi Ryosuke
- Seike Masahiro
- Sekikawa Yoshiyuki
- Shibata Shun
- Shibata Yoko
- Shibusawa Takayuki
- Shichinohe Yasuo
- Shimada Hisato
- Shimada Tadanaga
- Shimizu Eigo
- Shimizu Tetsuo
- Shimo Masatoshi
- Shimoda Masafumi
- Shinoki Masato
- Shinozuka Jun
- Shinozuka Keisuke
- Shiomi Tetsuya
- Shirai Yuya
- Shiroyama Takayuki
- Shoko Tomohisa
- Sinozaki Nobuaki
- Sonehara Kyuto
- Sonobe Kazunari
- Suematsu Ryohei
- Sueyoshi Atsushi
- Sugihara Fuminori
- Sugimoto Hideyasu
- Sugiura Hisatoshi
- Suzuki Junya
- Suzuki Ken
- Suzuki Motoyuki
- Suzuki Shoji
- Suzuki Takao
- Suzuki Yusuke
- Tachikawa Natsuo
- Tada Ai
- Tagaya Etsuko
- Takada Minoru
- Takagaki Masatoshi
- Takagi Haruhi
- Takahashi Hidenori
- Takahashi Hiroshi
- Takahashi Kazuhisa
- Takahashi Kenichiro
- Takahashi Kunihiko
- Takahashi Mai
- Takahashi Meiko
- Takahashi Saeko
- Takahashi Takeshi
- Takahashi Yasuo
- Takaku Yotaro
- Takano Kenji
- Takano Tomomi
- Takaoka Hatsuyo
- Takata Tohru
- Takayanagi Noboru
- Takeda Yoshito
- Takei Reoto
- Takemoto Norihiko
- Takeuchi Mayumi
- Taki Reiko
- Takita Mumon
- Takoi Hiroyuki
- Takuwa Ayako
- Tanaka Akihiko
- Tanaka Hiromu
- Tanaka Toru
- Tanaka Yoshiaki
- Tani Mayuko
- Tanino Yoshinori
- Tateishi Tomoya
- Tateno Hiroki
- Terai Hideki
- Terashima Mariko
- Togashi Yuki
- Tohda Shuji
- Tokunaga Katsushi
- Tokunaga Yoshihisa
- Tominaga Yoshiteru
- Tomono Kazunori
- Tone Mari
- Tsuburai Takahiro
- Tsuchida Tomoya
- Uchida Sho
- Uchida Tomoyuki
- Uchimura Yuji
- Ueda Ken
- Ueda Soichiro
- Ueda Suguru
- Ueda Tetsuya
- Ueno Takafumi
- Ueno Yuya
- Umeda Akira
- Uno Shunsuke
- Utsugi Mitsuyoshi
- Uwamino Yoshifumi
- Wada Daiki
- Wada Sae
- Wakabayashi Aya
- Wakahara Keiko
- Wang Qingbo S.
- Watanabe Chie
- Watanabe Hiroki
- Watanabe Hiroko
- Watanabe Kazuyoshi
- Watanabe Masafumi
- Wing James B.
- Yagi Kazuma
- Yamada Mitsuhiro
- Yamada Shuhei
- Yamada Yuichiro
- Yamagata Kunihiro
- Yamaguchi Hiroki
- Yamaguchi Yuta
- Yamaji Ken
- Yamamoto Kenichi
- Yamamoto Makoto
- Yamamoto Masaomi
- Yamamoto Yuji
- Yamanashi Yuji
- Yamano Yasuhiko
- Yamasaki Masaki
- Yamashita Tatsuya
- Yanagita Emmy
- Yasui Yoshinori
- Yatomi Masakiyo
- Yokote Koutaro
- Yoneda Midori
- Yonekawa Akiko
- Yoshida Eriko
- Yoshida Kosuke
- Yoshida Shozo
- Yoshida Shuichi
- Yoshida Toru
- Yoshifuji Ayumi
- Yoshihara Tomoyuki
- Yoshimori Kozo
- Yoshimura Yukihiro
- Yoshiya Kazuhisa
- Yoshiyama Takashi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force
- Author
- Abe Ryuzo
- Abe Shinji
- Adachi Tomohiro
- Adachi Yuichi
- Ai Masumi
- Amishima Masaru
- Amiya Saori
- Anan Ryusuke
- Ando Akira
- Anzai Tatsuhiko
- Arai Daisuke
- Arai Ryosuke
- Arai Sawako
- Arakawa Kenichi
- Arimura Ken
- Asakura Takanori
- Asano Koichiro
- Awano Nobuyasu
- Azuma Masanori
- Baba Hiroaki
- Baba Rie
- Baba Tomoya
- Beppu Satoru
- Chiba Shigeru
- Chihara Yusuke
- Chubachi Shotaro
- Edahiro Ryuya
- Egi Moritoki
- Endo Akifumi
- Endo Mayu
- Enomoto Takatoshi
- Eriguchi Yoshihiro
- Fuchimoto Yasuko
- Fujii Kazuhiko
- Fujimoto Nobukazu
- Fujita Kazue
- Fujitani Shigeki
- Fujiwara Akiko
- Fuke Satoshi
- Fukui Takahiro
- Fukui Yasutaka
- Fukunaga Koichi
- Fukuta Tetsuya
- Fukuyama Satoru
- Funatsu Yohei
- Gon Yasuhiro
- Hagihara Masao
- Hagimoto Satoshi
- Hagiwara Eri
- Hagiwara Shigehiro
- Hanada Satoko
- Hara Reina
- Harada Masahiro
- Harada Norihiro
- Harada Sonoko
- Harada Yuko
- Haruta Yuki
- Hase Isano
- Hasegawa Naoki
- Hasegawa Takanori
- Hasegawa Yoshinori
- Hashiguchi Mizuha
- Hashimoto Naozumi
- Hashimoto Satoru
- Hashino Takuya
- Hattori Takeshi
- Hayashi Kentaro
- Hayashi Reina
- Hayashi Shinichi
- Hida Naoya
- Hiki Makoto
- Hirai Yoshihiro
- Hiramatsu Yuji
- Hirano Toshiyuki
- Hiranuma Hisato
- Hirata Haruhiko
- Hirouchi Takatomo
- Honda Takayuki
- Horinouchi Hirohisa
- Hoshino Kota
- Hosoda Chiaki
- Hyugaji Takayoshi
- Ichikado Kazuya
- Ichikawa Masako
- Ichimura Naoya
- Igarashi Akira
- Ihara Shoichi
- Ikemura Shinnosuke
- Imamura Tomonori
- Imoto Seiya
- Inomata Minoru
- Inoue Sumito
- Inoue Takashi
- Inoue Takuya
- Inoue Yoshiaki
- Ishiguro Takashri
- Ishihara Sayoko
- Ishihara Shoichiro
- Ishii Makoto
- Ishii Tomoo
- Ishikawa Motonao
- Ishikura Hiroyasu
- Ishioka Kota
- Isogai Susumu
- Isono Taisuke
- Ito Akihiro
- Ito Fumimaro
- Ito Kazuto
- Ito Satoshi
- Ito Yoko
- Iwagoe Hajime
- Iwamura Hiromu
- Izumi Namiki
- Izumo Takehiro
- Kabata Hiroki
- Kagaya Takashi
- Kagyo Junko
- Kai Hirayasu
- Kamata Hirofumi
- Kamimaki Isamu
- Kamiya Akane
- Kan-o Keiko
- Kanai Masahiro
- Kanai Masayuki
- Kanai Takanori
- Kanaoka Kensuke
- Kanayama Syuji
- Kanda Hidenori
- Kanehiro Arihiko
- Kaneko Yutaro
- Kaneyama Yasunari
- Kasamatsu Yu
- Kashiwada Takeru
- Katayama Kazuhiko
- Katayama Kotoe
- Kato Kazuto
- Kato Yasuhiro
- Kawada Miki
- Kawamura Kodai
- Kawana Akihiko
- Kawana Masatoshi
- Kawashima Hidetoshi
- Kikuchi Ryota
- Kimizuka Yoshifumi
- Kimura Akinori
- Kimura Nozomu
- Kimura Tomoki
- Kimura Tomoyuki
- Kimura Yasuhiro
- Kishi Hiroto
- Kita Toshiyuki
- Kitagawa Yuichiro
- Kitagawa Yuko
- Kitamura Hideya
- Kobayashi Keigo
- Kobayashi Yoichi
- Kodaka Norio
- Kodama Nobuhiro
- Koh Hidefumi
- Kohashi Sumiko
- Koike Ryuji
- Koji Sakamoto
- Kojima Mitsuaki
- Kokuto Hiroyuki
- Komase Yuko
- Komuta Kiyoshi
- Konishi Shunichiro
- Kono Yuta
- Koshida Kiyoshi
- Kozu Yutaka
- Kuge Tomoki
- Kumanogoh Atsushi
- Kuraki Takashige
- Kuramochi Mizuki
- Kurihara Yuko
- Kusaka Yu
- Kuse Naoyuki
- Kuwahara Naota
- Lee Ho
- Maeda Shunsuke
- Maeno Toshitaka
- Makino Shohei
- Makino Yasushi
- Manabe Tadashi
- Maruyama Junichi
- Maruyama Shuhei
- Masaki Katsunori
- Mashimo Shuko
- Masuda Makoto
- Masuzawa Keita
- Matsui Yuma
- Matsumoto Kinnosuke
- Matsumoto Koichiro
- Matsumoto Shuichiro
- Matsumoto Takemasa
- Matsunaga Tomohiro
- Matsuse Hiroto
- Matsushita Yasushi
- Minemura Hiroyuki
- Mitamura Keiko
- Miyagawa Kazuya
- Miyake Takahito
- Miyano Satoru
- Miyawaki Masayoshi
- Miyazaki Masatoshi
- Miyazaki Yasunari
- Miyazaki Yoshimune
- Miyazawa Naoki
- Mochimaru Takao
- Mori Nobuaki
- Morikawa Daiki
- Morisaki Hiroshi
- Morita Atsuho
- Morita Takayoshi
- Motegi Mitsuru
- Murakami Koji
- Murakami Teruaki
- Muranaka Hiroyuki
- Murohashi Kota
- Mutoh Yoshikazu
- Nagai Hideaki
- Nagao Genta
- Nagasaka Tomoki
- Nagasaki Tadao
- Nagasaki Yoji
- Nagata Kaoru
- Naito Tatsuhiko
- Naito Toshio
- Nakachi Ichiro
- Nakada Taka-Aki
- Nakajima Jun
- Nakajima Yukiko
- Nakamori Yasushi
- Nakamura Ai
- Nakamura Kazunori
- Nakamura Morio
- Nakamura Yoshihiko
- Nakano Chihiro
- Nakano Yasushi
- Nakatsumi Hiroki
- Nakayama Sohei
- Namba Shinichi
- Namkoong Ho
- Nanki Kosaku
- Nannya Yasuhito
- Narita Atsuya
- Narumoto Osamu
- Niitsu Takayuki
- Nikaido Takefumi
- Nishi Koichi
- Nishida Takashi
- Nishikawa Masanori
- Nishimura Tomoyasu
- Nishio Kazumi
- Nishitsuji Masaru
- Nishiyama Kei
- Nishiyama Kenta
- Niwa Kazuki
- Noda Yoshimi
- Noguchi Yoichiro
- Nukaga Shigenari
- Ochi Junichi
- Odani Toshio
- Odate Mitsuru
- Ogata Hideo
- Ogata Tomouki
- Ogawa Aki
- Ogawa Seishi
- Ogawa Shinichi
- Oguma Tsuyoshi
- Ogura Shinji
- Ogura Takashi
- Ogura Takayuki
- Ohba Takehiko
- Ohira Yoshiyuki
- Ohta Kazuhide
- Ohta Ken
- Ohta Shin
- Okabayashi Hiroko
- Okada Takenori
- Okada Yukinori
- Okamori Satoshi
- Okamoto Masaki
- Omae Yosuke
- Omote Norihito
- Ono Akihiro
- Ono Hiroshi
- Ono Yoshinao
- Onoi Keisuke
- Ooshima Nobuharu
- Osawa Takeshi
- Oshima Taku
- Oshio Takeshi
- Ota Sho
- Oyama Baku
- Oyamada Yoshitaka
- Ozaki Shinji
- Sado Reiko
- Sado Toshikatsu
- Sagara Hironori
- Sageshima Hisako
- Saiki Ryunosuke
- Saito Fukuki
- Saito Fumitake
- Saito Hiroshi
- Saito Ryuichi
- Saito Yoshinobu
- Sakagami Satoru
- Sakurai Toshihiro
- Sandhu Yuuki
- Sano Hirohito
- Sano Tomoya
- Sasa Noah
- Sasaki Junichi
- Sasaki Kana
- Sasano Hajime
- Sassa Chihiro Tani
- Sato Masamichi
- Sato Ryuichi
- Sato Tomonori
- Sato Toshiro
- Sato Yoko
- Sato Yuki
- Satomi Ryosuke
- Seike Masahiro
- Sekikawa Yoshiyuki
- Shibata Shun
- Shibata Yoko
- Shibusawa Takayuki
- Shichinohe Yasuo
- Shimada Hisato
- Shimada Tadanaga
- Shimizu Eigo
- Shimizu Tetsuo
- Shimo Masatoshi
- Shimoda Masafumi
- Shinoki Masato
- Shinozuka Jun
- Shinozuka Keisuke
- Shiomi Tetsuya
- Shirai Yuya
- Shiroyama Takayuki
- Shoko Tomohisa
- Sonehara Kyuto
- Sonobe Kazunari
- Suematsu Ryohei
- Sueyoshi Atsushi
- Sugimoto Hideyasu
- Sugiura Hisatoshi
- Suzuki Junya
- Suzuki Shoji
- Suzuki Yusuke
- Tada Ai
- Tagaya Etsuko
- Takada Minoru
- Takagi Haruhi
- Takahashi Hidenori
- Takahashi Hiroshi
- Takahashi Kazuhisa
- Takahashi Kenichiro
- Takahashi Kunihiko
- Takahashi Mai
- Takahashi Saeko
- Takahashi Takeshi
- Takaku Yotaro
- Takano Kenji
- Takano Tomomi
- Takaoka Hatsuyo
- Takata Tohru
- Takayanagi Noboru
- Takeda Yoshito
- Takei Reoto
- Takeuchi Mayumi
- Taki Reiko
- Takita Mumon
- Takoi Hiroyuki
- Tanaka Akihiko
- Tanaka Hiromu
- Tanaka Toru
- Tanaka Yoshiaki
- Tani Mayuko
- Tanino Yoshinori
- Tateishi Tomoya
- Tateno Hiroki
- Terai Hideki
- Terashima Mariko
- Togashi Yuki
- Tohda Shuji
- Tokunaga Katsushi
- Tokunaga Yoshihisa
- Tominaga Yoshiteru
- Tomono Kazunori
- Tone Mari
- Tsuburai Takahiro
- Tsuchida Tomoya
- Uchida Sho
- Uchida Tomoyuki
- Uchimura Yuji
- Ueda Ken
- Ueda Soichiro
- Ueda Suguru
- Ueda Tetsuya
- Ueno Takafumi
- Umeda Akira
- Uno Shunsuke
- Utsugi Mitsuyoshi
- Uwamino Yoshifumi
- Wada Daiki
- Wada Sae
- Wakabayashi Aya
- Wakahara Keiko
- Wang Qingbo S.
- Watanabe Chie
- Watanabe Hiroki
- Watanabe Hiroko
- Watanabe Kazuyoshi
- Watanabe Masafumi
- Yagi Kazuma
- Yamada Mitsuhiro
- Yamada Yuichiro
- Yamagata Kunihiro
- Yamaguchi Yuta
- Yamamoto Kenichi
- Yamamoto Makoto
- Yamamoto Masaomi
- Yamamoto Yuji
- Yamano Yasuhiko
- Yamasaki Masaki
- Yamashita Tatsuya
- Yasui Yoshinori
- Yatomi Masakiyo
- Yokote Koutaro
- Yoneda Midori
- Yonekawa Akiko
- Yoshida Eriko
- Yoshida Kosuke
- Yoshida Shozo
- Yoshida Shuichi
- Yoshida Toru
- Yoshifuji Ayumi
- Yoshihara Tomoyuki
- Yoshiya Kazuhisa
- Yoshiyama Takashi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
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- Ashcroft Kevin
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- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
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- Atkinson Barry
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- Chillingworth Neil
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- Iliev Ilian
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- Imo Kelvin C.
- Inacio Nicole
- Inagaki Naomi
- Ince Michael
- Ingram Drew
- Inoue Shuuji
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- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
- Isozaki Emi
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- Ito Fumiaki
- Ito Noriko
- Itoh Takehiko
- Iwakawa Shinobu
- Iwatate Mariko
- Iwatsu Mikiko
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- Izatt Janet
- Izmajlowicz Monica
- Izumiyama Tomohiro
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- Jackson Terri
- Jacob Leni Susan
- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
- James Kent W.
- Jareborg Niclas
- Jarek Michael
- Jassal Bijay
- Jeffery Grant
- Jeffery Kim
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- Jekosch Kerstin
- Jenkins Lee
- Jett Jamie
- Jewett Phillip E.
- Jia Jia
- Jia Jia
- Jia Nan
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- Jiang Lu
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- Kettleborough Ross
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- Khan Ziad Mohid
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- Kou Zhaohui
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- Kube Michael
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- Lander Eric S.
- Landers Tom
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- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
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- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
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- Lu Yongxiang
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- Lucier Raymond L.
- Ludeman Thom
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- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
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- Manohar Chitra
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- Mauceli Evan
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- McMurray Kimberly
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- McPherson John
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- Meidi Patrick
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- Mungall Andy
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- Murayama Yuji
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- Nguyen Ngoc Bich
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- Nordsiek Gabriele
- Norris Sarah Louise
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- Nowlin Larry
- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
- O\u27Leary Sinead
- O\u27Loughlin Jennifer
- O\u27Neill Keith
- Obayashi Izumi
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- Omotosho Bamidele
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- Oragunye Njideka
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- Ovcharenko Ivan
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- Oviedo Rodolfo J.
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- Pan Jiaofeng
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- Perez Agapito
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- Perito Andrew
- Perrault Isabelle
- Perrier Rene
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- Pesavento Brad
- Peters Anna
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- Peterson Jane
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- Poundstone Pat
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- Prathalingham Radhika
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- Prigmore Elena
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- Qiang Boqin
- Qiao Zhenyong
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- Quan Glenda
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- Quiles Miyo M.
- Quince Chris
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- Radionenko Maxim
- Rajagopal Mohan
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- Reily Amy D.
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- Sonaike Titilola
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- Sonnhammer Erik
- Sonnhammer Erik
- Sorelle Richard P.
- Sotheran Elizabeth
- Sougnez Carrie
- Spainhower Corey
- Sparks Anastasia L.
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- Spraggon Lee
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- Stabenau Arne
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- Stallings Raymond I.
- Stalvey Malinda
- Stamford Steve
- Stammers Melanie
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- Sudbrak Ralf
- Sugnet Charles W.
- Sulston John
- Summers Leslie J.
- Sun Hui
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- Sun Min
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- Sun Wei
- Sun Yongqiao
- Sun Yu
- Sun Yue
- Sutherland Grant R.
- Sutherland Robert D.
- Sutton Angelica E.
- Svatek Amanda F.
- Svetz Jessica
- Svetz Leah Anne
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- Sycamore Neil
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- Tabor Paul E.
- Tacey Kristina
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- Takaoka Tori
- Takayanagi Atsushi
- Takenaka Tracy
- Talamas Jessica
- Tam Serena
- Tamerisa Kavitha S.
- Tamirisa Aparna
- Tan Olivia
- Tan Steven
- Tan Xinyu
- Tan Xinyu
- Tang Hongli
- Tang Xiangjun
- Tansey Jennifer
- Tao Ran
- Tapia Roxanne
- Taring Elizabeth
- Tatsuyama Miho
- Tatum Owatha I.
- Taudien Stefan
- Taylor Amy
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- Taylor Kate
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- Taylor Tineace R.
- Taylor Todd Duane
- Tchuinga Pierre
- Tee Louise
- Telford Ethan Brett
- Tenzin Pema
- Terada Yoriko
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- Tesfaye Senait
- Tesmer Judith G.
- Tester Julieanne
- Thayer Nina
- Theaker Andrew
- Theil James
- Theodore Joumathe
- Thexton David
- Thies Stephanie
- Thomas Craig
- Thomas Daniel
- Thomas Daryl J.
- Thomas Karen
- Thomas Nicole
- Thomas Paulette
- Thomas Ruth
- Thomas Shereen
- Thommai Roselin
- Thompson Linda S.
- Thorne Rachel Diane
- Thorpe Andrea
- Thorpe Karen
- Thoulutsang Yama
- Threadgold Glen
- Thurston Scott
- Tian Chaoguang
- Tian Chaoguang
- Tian Wei
- Tian Yan
- Tian Yong
- Tian Yuqing
- Tice Hope
- Tighe Damon
- Tin-Wollam Aye M.
- Tinsley Emma
- Tochigi Miwako
- Togashi Naoko
- Tomizawa Iori
- Tomlinson Chad
- Tong Jingli
- Topham Kerri
- Torcaso Bill
- Torney David C.
- Totoki Yasushi
- Towey Sarah
- Toyoda Atsushi
- Tracey Alan
- Tran Ly Thanh
- Tran-Gyamfi Mary
- Trani Lee
- Trankiem Margie
- Trask Barbara J.
- Travers Johnathan
- Trejos Zulma Y.
- Treuhaft Marianne
- Trevino Brenda Kaye
- Tromans Anthony
- Trong Stephan
- Trumbower Heather
- Tsai Ming
- Tsamla Tsamla
- Tsolas Jason
- Tsomo Nawang
- Tsujimoto Susan
- Tsukamoto Yumi
- Tsuruoka Hiromi
- Tsuzuki Rina
- Tu Yuefeng
- Tu Yuefeng
- Tubby Ben
- Tufarelli Cristina
- Turner Heidi
- Turney Kathryn
- Tynan Katherine
- Ueland Stephanie
- Ueng Samantha
- Ukegbu Ogechi Nkemdirim
- Ulanovsky Levy E.
- Un Chun
- Ung Quyen
- Upson Darren
- Urban Jeremy B.
- Ureta-Vidal Abel
- Ureta-Vidal Abel
- Usmani Kamran
- Ustaszewska Anna
- Uyama Nozomi
- Valas Ruben E.
- Valdez Michelle
- Valle Duane
- Valles Yvonne
- Van Brunt Andrew
- Van Dilla Marvin
- Van Helmond Zoe
- Van Luchene Ryan
- Vardanian Zachary
- Vargas Michelle
- Vargo Charles E.
- Vartanian Steffan
- Vasquez Lydia I.
- Vassiliev Helen
- Vastrik Imre
- Vaudin Mark
- Veil Rose
- Veklerov Eugene
- Velasco Nelson
- Velasquez Lisa
- Venkataranan Vijay
- Vera Virginia A.
- Verduzco Daniel
- Vergez Lisa
- Vico Virginie
- Viknaraja Ramya
- Villasana Donna M.
- Vine Wendy
- Viswanathan Vijay
- Vo Andy
- Vo Nu
- Voak Paul
- Vollenhoven David
- Wada Hiromi
- Wagner Mark
- Wagner-McPherson Caryn
- Waldron Lenee
- Waligorski Jason E.
- Walker Davian L.
- Walker Keya
- Walker Sarah
- Wall Melanie
- Wall Randy E.
- Wallace John
- Wallis Justine
- Wallis Michelle
- Walsh Jennifer
- Walsham Natalie
- Wan Ma
- Wang Chunyan
- Wang Dong
- Wang Feng
- Wang Guangxin
- Wang Guihai
- Wang Guihai
- Wang Hongjuan
- Wang Hongwei
- Wang Huanjie
- Wang Huifeng
- Wang Huifeng
- Wang Jian
- Wang Jian
- Wang Jian
- Wang Jie
- Wang Jing
- Wang Jingqiang
- Wang Jingqiang
- Wang Jinhua
- Wang Joann
- Wang Juan
- Wang Jun
- Wang Jun
- Wang Jun
- Wang Li
- Wang Lijie
- Wang Lijuan
- Wang Lijun
- Wang Ling
- Wang Liqun
- Wang Mei
- Wang Qiaoyan
- Wang Shifen
- Wang Shu
- Wang Suzhen
- Wang Wenjun
- Wang Xiaoling
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- Wang Xuegang
- Wang Yan
- Wang Yimin
- Wang Ying
- Wang Ying
- Wang Yuanyuan
- Wangchuck Tsering
- Wangdi Tsering
- Ward-Moore Stephanie
- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
- Watson Andy
- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
- Weidenbach Richard
- Weinstock George
- Weinstock Keith
- Weir John
- Weissenbach Jean
- Wells Alan
- Wells Sarah
- Welton Robert
- Wen Gaiping
- Wendi Mike
- Weng Li
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- Wheatley Carl
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- Wheeler Gideon
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- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
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- Wilkinson Jane
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- Willey David
- Williams Albert L.
- Williams Andy
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- Williamson Helen
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- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
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- Wooden Steven H.
- Woodeson Sharon
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- Worley Kim Carlyle
- Woyke Tanja
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- Wu Chungen
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- Wylie Kris
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- Xi Yan
- Xi Yingying
- Xie Fei
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- Xiong Hui
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- Xu Alex
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- Xu Jing
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- Xu Yuning
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- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
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- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
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- You Bo
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- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
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- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Family Members Identification with Brightness Distribution Sensors to Self-sustaining of Power as Personal Actions
- Publication venue
- IFSA Publishing, S.L.
- Publication date
- 01/11/2015
- Field of study
There are many attempts to recognize actions using sensors in homes. Some of them aim to keep watching on the elderly living alone, while others try to bring ecological life, scheduling domestic actions consuming energy. We need an inexpensive method to make it prevail in the society. In the meantime, recognition results threaten privacy, if outsiders obtain them. Almost all people mind whether they are used in malicious ways. The sensor should prevent the leak of the privacy of users. This work proposes a method to recognize various domestic actions with a single kind of sensors, which is not only inexpensive, but also safe enough to protect the privacy. The method uses brightness distribution sensors presenting a sequence of cells, each of which indicates the brightness of one direction in the view area of the sensor. The method gets local features along with the persons who conduct domestic actions. The method enables to recognize both of domestic actions and the period in which they are conducted. To evaluate the accuracy of the method, 10 men and women have participated in an experiment, where they take various domestic actions in their own ways with 4 brightness distribution sensors installed on the wall of an actual kitchen. As a result, the method has marked high performance on the recognition of “vacuuming”, “cooking”, and “taking a rest”, along with their periods. The method also identifies all examinees who conduct them in high accuracy. It is possible to recognize domestic actions in actual home spaces
DEHYDROGENASES IN LOCAL CARCINOGENESIS IN RAT MAMMARY GLAND BY DUSTING OF DMBA-POWDER
- Publication venue
- 'Japan Society of Histochemistry & Cytochemistry'
- Publication date
- 01/01/1980
- Field of study
Risk assessment of hypertensive disorders in pregnancy with maternal characteristics in early gestation: A single-center cohort study
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Clinical features and antenatal risk factors for postpartum-onset hypertensive disorders
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Impact of frailty on long-term mortality in older patients receiving intensive care via the emergency department
- Author
- Aita Kaoruko
- Harada Masahiro
- Inaba Mototaka
- Ishihara Satoshi
- Ishikawa Hideki
- Kohama Keisuke
- Maeyama Hiroki
- Mayumi Toshihiko
- Muramatsu Shun
- Naito Hiromichi
- Nakamichi Chikaaki
- Nakao Atsunori
- Nozaki Satoshi
- Ohtsuka Tsuyoshi
- Sakurai Ryota
- Sato Shuho
- Shime Nobuaki
- Takaoka Makoto
- the LIFE Study Investigators
- Uemori Sadayori
- Yamashita Kazunori
- Yorifuji Takashi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study