Radiatively induced leptogenesis in a minimal seesaw model

We study the possibility that the baryon asymmetry of the universe is generated in a minimal seesaw scenario where two right-handed Majorana neutrinos with degenerate masses are added to the standard model particle content. In the usual framework of thermal leptogenesis, a nonzero $CP$ asymmetry can be obtained through the mass splitting induced by the running of the heavy Majorana neutrino masses from their degeneracy scale down to the seesaw scale. Although, in the light of the present neutrino oscillation data, the produced baryon asymmetry turns out to be smaller than the experimental value, the present mechanism could be viable in simple extensions of the standard model.Comment: 6 pages, 2 figures, uses RevTeX4, calculations improved, comments adde

Consequences of the H-Theorem from Nonlinear Fokker-Planck Equations

A general type of nonlinear Fokker-Planck equation is derived directly from a master equation, by introducing generalized transition rates. The H-theorem is demonstrated for systems that follow those classes of nonlinear Fokker-Planck equations, in the presence of an external potential. For that, a relation involving terms of Fokker-Planck equations and general entropic forms is proposed. It is shown that, at equilibrium, this relation is equivalent to the maximum-entropy principle. Families of Fokker-Planck equations may be related to a single type of entropy, and so, the correspondence between well-known entropic forms and their associated Fokker-Planck equations is explored. It is shown that the Boltzmann-Gibbs entropy, apart from its connection with the standard -- linear Fokker-Planck equation -- may be also related to a family of nonlinear Fokker-Planck equations.Comment: 19 pages, no figure

Misdiagnosis of leprosy in Brazil in the period 2003-2017: spatial pattern and associated factors

BACKGROUND: Leprosy causes a range of symptoms, and most diagnoses are established based on the clinical picture. Therefore, false negative and positive diagnoses are relatively common. We analyzed the spatial pattern of leprosy misdiagnosis and associated factors in Brazil. METHOD: Exploratory analyses of Kernel density of the new case detection rate (NCDR) and proportion of misdiagnosis in Brazil, 2003 - 2017. Factors associated with misdiagnosis were identified by logistic regression at the 5% significance level. RESULT: A total of 574,181 new leprosy cases were recorded in Brazil, of which 7,477 (1.3%) were misdiagnoses. No spatial correlation was observed between the proportion of misdiagnoses and the NCDR. The likelihood of misdiagnosis was elevated for females [OR: 1.58 (1.51 - 1.66)], children [OR: 1.49 (1.36 - 1.64)]; paucibacillary [OR: 1.08 (1.02 - 1.13)], indeterminate clinical forms [OR: 2.37 (2.15 - 2.62)], for cases diagnosed in the frame of mass screenings [OR: 3.36 (3.09- 3.73)] and contact examination [OR: 2.30 (2.13 - 2.49)] and for cases with affected nerves but no skin lesions [OR: 2.47(2.19 - 2.77)] when compared with those presenting both skin lesion and affected nerves. CONCLUSION: Misdiagnosis of leprosy is not correlated with the endemicity level in Brazil but rather with personal, diagnosis-related and disease characteristics

Deployment of spatial attention towards locations in memory representations: an EEG study

Recalling information from visual short-term memory (VSTM) involves the same neural mechanisms as attending to an actually perceived scene. In particular, retrieval from VSTM has been associated with orienting of visual attention towards a location within a spatially-organized memory representation. However, an open question concerns whether spatial attention is also recruited during VSTM retrieval even when performing the task does not require access to spatial coordinates of items in the memorized scene. The present study combined a visual search task with a modified, delayed central probe protocol, together with EEG analysis, to answer this question. We found a temporal contralateral negativity (TCN) elicited by a centrally presented go-signal which was spatially uninformative and featurally unrelated to the search target and informed participants only about a response key that they had to press to indicate a prepared target-present vs. -absent decision. This lateralization during VSTM retrieval (TCN) provides strong evidence of a shift of attention towards the target location in the memory representation, which occurred despite the fact that the present task required no spatial (or featural) information from the search to be encoded, maintained, and retrieved to produce the correct response and that the go-signal did not itself specify any information relating to the location and defining feature of the target

APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review

APOE-\u3b54 is best known as a risk factor for Alzheimer's disease (AD). Consequently, there is considerable research interest in understanding whether APOE-\u3b54 influences cognition in healthy adults. Despite a substantial literature reporting effects of APOE genotype on cognition, findings are inconsistent. In particular, it is challenging to separate whether cognitive deficits in APOE-\u3b54 carriers reflect the influence of prodromal dementia pathology (\u201cprodromal hypothesis\u201d), or a direct contribution of APOE genotype to individual differences (\u201cphenotype hypothesis\u201d). Variable methodology across studies further complicates the issue. These challenges have limited what can be learnt about the processes underlying cognitive ageing and dementia by studying the influence of APOE genotype on cognition. In this review, we focus on the two compatible neurobiological mechanisms by which APOE genotype may influence cognition in healthy adults (prodromal and phenotype). We summarise the behavioural evidence for the influence of APOE on cognition in non-demented adults and explore key methodological challenges for disentangling the cognitive effects of different neurobiological mechanisms of APOE. Evidence suggests that at least some APOE-\u3b54 cognitive deficits are due to early AD pathology, whilst sensitive measures of cognition are beginning to reveal subtle cognitive differences between APOE genotypes in mid-adulthood, prior to the onset of the AD prodromal period. We conclude with recommendations for future research to investigate the cognitive consequences of neurobiological processes affected by APOE and maximise the translational potential of this research

From the nonlinear Fokker-Planck equation to the Vlasov description and back: Confined interacting particles with drag

Nonlinear Fokker-Planck equations endowed with power-law diffusion terms have proven to be valuable tools for the study of diverse complex systems in physics, biology, and other fields. The nonlinearity appearing in these evolution equations can be interpreted as providing an effective description of a system of particles interacting via short-range forces while performing overdamped motion under the effect of an external confining potential. This point of view has been recently applied to the study of thermodynamical features of interacting vortices in type II superconductors. In the present work we explore an embedding of the nonlinear Fokker-Planck equation within a Vlasov equation, thus incorporating inertial effects to the concomitant particle dynamics. Exact time-dependent solutions of the q-Gaussian form (with compact support) are obtained for the Vlasov equation in the case of quadratic confining potentials.Fil: Plastino, Ángel Ricardo. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Bioinvestigaciones (Sede Pergamino); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Curado, E. M. F.. Centro Brasileiro de Pesquisas Físicas; BrasilFil: Nobre, F. D.. Centro Brasileiro de Pesquisas Físicas; BrasilFil: Tsallis, C.. Centro Brasileiro de Pesquisas Físicas; Brasil. Santa Fe Institute; Estados Unidos. Complexity Science Hub Vienna; Austri

Thermostatistics of overdamped motion of interacting particles

We show through a nonlinear Fokker-Planck formalism, and confirm by molecular dynamics simulations, that the overdamped motion of interacting particles at T=0, where T is the temperature of a thermal bath connected to the system, can be directly associated with Tsallis thermostatistics. For sufficiently high values of T, the distribution of particles becomes Gaussian, so that the classical Boltzmann-Gibbs behavior is recovered. For intermediate temperatures of the thermal bath, the system displays a mixed behavior that follows a novel type of thermostatistics, where the entropy is given by a linear combination of Tsallis and Boltzmann-Gibbs entropies.Comment: 4 pages, 2 figure