2,732 research outputs found
Up in the Air Without a Ticket: Interpretation and Revision of the Warsaw Convention
This Note will examine the validity of the Convention\u27s objective contract approach to defining international transportation. Although the Convention\u27s requirements will be discussed separately, the focus will be upon the regulated contract and the relationship between article 1 and article 3 of the Convention. The need for revising the Convention will be discussed and a proposal for a new definition of international transportation will be made
XP customer practices: A grounded theory
The Customer is a critical role in XP, but almost all XP practices are presented for developers by developers. While XP calls for Real Customer Involvement, it does not explain what XP Customers should do, nor how they should do it. Using Grounded Theory, we discovered eight customer practices used by successful XP teams: Customer Boot Camp, Customer’s Apprentice, Customer Pairing, and Programmer’s Holiday support the well-being and effectiveness of customers; Programmer On-site and Road shows support team and organization interactions; and Big Picture Up Front and Re-calibration support Customers steering the whole project. By adopting these processes, XP Customers and teams can work faster and more sustainably
The XP customer team: A grounded theory
The initial definition of XP resulted in many people interpreting the on-site customer to be a single person. We have conducted extensive qualitative research studying XP teams, and one of our research questions was “who is the customer”? We found that, rather than a single person, a customer team always exists. In this paper we outline the different roles that were typically on the team, which range from the recognized “Acceptance Tester” role to the less recognized roles of “Political Advisor” and “Super-Secretary”
Guinevere, the Superwoman of Contemporary Arthurian Fiction
This essay explores efforts by Sharan Newman, Persia Woolley, and Rosalind Miles, authors of three Guinevere trilogies published between 1981 and 2001, to transform Guinevere from a peripheral into a central figure in the Arthurian legend by depicting her as a psychologically complex figure who is sufficiently accomplished in all areas of her life to qualify, in Elisabeth Brewer's terms, as a "superwoman." The emphasis devoted in these revisionist texts to Guinevere's role as mother not only of either biological or adopted children but also of the land over which she and Arthur jointly rule marks a significant departure from patriarchal versions of the Arthurian legend and invites comparison with what Marion Zimmer Bradley may have been attempting to accomplish in her enigmatic characterization of Gwenhwyfar in the fourth and final section of The Mists of Avalon
Folk Art in Art Education: Toward a General Theory of Art as a Social Institution
Art may be understood by considering it as a social institution in which particular artifacts are presented as candidates for appreciation. This institution includes the domains of production, distribution, and consumption, all of which are regulated according to rules and standards relating to both art objects and behavioral roles for those people involved. In the paradigm case all participants in the institution are of the same cultural group. This is important for art educators to understand because of the diversity of cultures represented in the classroom. Because a person\u27s greatest opportunity for meaningful involvement in the arts comes from within his or her native culture, art education which is excessively tied to the fine arts represents a form of cultural imperialism which alienates most students as potential participants in the arts
Exploring Perceived Norms and Protective Strategies: Self-Consciousness and Gender as Moderators
College alcohol abuse has been a staple in the college environment over the past 30 years (Johnston, O’Malley, Bachman, & Schulenberg, 2011) resulting in numerous negative consequences (Hingson, Edwards, Heeren, & Rosenbloom, 2009). Protective behavioral strategies (PBS) reduce the negative consequences typically associated with alcohol use (Martens et al., 2004). A positive relationship exists between perceived norms of PBS use and PBS use (Benton, Downey, Glider, & Benton, 2008), and an individual’s level of self-consciousness moderates the relationship between perceived norms and alcohol use (LaBrie, Hummer, & Neighbors, 2008). The relationship between perceived norms and PBS use under the conditions of self-consciousness has yet to be assessed. The current study aimed to assess to what extent perceived norms predicted PBS use with private self-consciousness, public self-consciousness, and social anxiety as moderators. Due to gender differences observed in these variables (Johnston et al., 2011; LaBrie, Pedersen, Neighbors, & Hummer, 2008), gender was also assessed as a moderator. Results revealed that perceived norms predicted an increase in PBS use. Private and public self-consciousness also predicted an increase in PBS use. A three-way interaction emerged between descriptive norms, private self-consciousness, and gender. Implications for college student intervention and prevention programs are discussed, as well as limitations of the study and directions for future research
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The biological and pharmacological allosteric modulation of inositol monophosphatase
The purpose of this project was to develop novel pharmacological tools against Inositol Monophosphatase (IMPase) and gain new insights into the Calbindin-IMPase interaction. IMPase is an enzyme that has been of significant therapeutic interest since the development of the inositol depletion hypothesis of lithium’s efficacy in the treatment of bipolar disorder. More recent studies have implicated IMPase inhibition in the induction of autophagy and the clearance of peptides involved in the pathogenesis of neurodegenerative diseases. Despite this there is a lack of specific inhibitors and those that have been developed lack favorable physiochemical properties to explore specific IMPase inhibition in vivo. My aim was to find novel inhibiters and binding chemical fragments that could later be developed into potent specific inhibitors of IMPase that would allow for the specific evaluation of IMPase inhibition in vivo. To achieve this, two approaches were tried: first a crystallographic fragment soaking screen was used to identify novel binding sites and chemical matter. This resulted in the discovery of a novel fragment binding site at the homodimer interface and mutagenesis at this site inhibited IMPase activity, indicating that the site could be therapeutically relevant. The second approach was to screen a specially curated isothiazolone library based on the previously identified covalent inhibitor Ebselen. Here I identified a new class of isothiazolone inhibitors of IMPase.
The calcium binding protein Calbindin-D28k can allosterically modulate IMPase, this results in the increase in the catalytic activity of IMPase. I aimed to explore this interaction by fusing the proteins using a flexible amino acid linker. The resulting complexes had activity in excess of that of the wild type IMPase, confirming that Calbindin-D28k activated IMPase. Low resolution structural analysis using small angle X-ray scattering (SAXS) revealed a V-shaped IMPase-calbindin complex which was in contrast to the more linear shape predicted by computational docking models. Here we also obtained the first crystal structure of Calbindin-D28k. This crystal structure gave the first direct visualization of the calcium binding sites of the protein and is a better model of Calbindin-D28k in solution than the previous NMR structure
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