Symptom relief with moderate dose chemotherapy (mitomycin-C, vinblastine and cisplatin) in advanced non-small cell lung cancer.

Twenty-four symptomatic patients with advanced non-small cell lung cancer (NSCLC) were treated with cisplatin-based chemotherapy (mitomycin-C 8 mg m-2 q 6 weeks, vinblastine 6 mg m-2 q 3 weeks, cisplatin 50 mg m-2 q 3 weeks). Patients were assessed for symptom relief as well as for objective response. Although only five patients achieved an objective response (21%), 18 patients (75%) reported a complete disappearance or good improvement in at least one of their tumour-related symptoms. The overall symptomatic response rate was 67% with 16 patients feeling better or much better on treatment. The toxicity of treatment (primarily myelosuppression and nausea and vomiting) was mild and hair loss was minimal. The high incidence of symptomatic relief seen in this study, even in the absence of objective response, suggests that moderate dose chemotherapy may have a role in the palliation of NSCLC

Knowledge-based vision and simple visual machines

The vast majority of work in machine vision emphasizes the representation of perceived objects and events: it is these internal representations that incorporate the 'knowledge' in knowledge-based vision or form the 'models' in model-based vision. In this paper, we discuss simple machine vision systems developed by artificial evolution rather than traditional engineering design techniques, and note that the task of identifying internal representations within such systems is made difficult by the lack of an operational definition of representation at the causal mechanistic level. Consequently, we question the nature and indeed the existence of representations posited to be used within natural vision systems (i.e. animals). We conclude that representations argued for on a priori grounds by external observers of a particular vision system may well be illusory, and are at best place-holders for yet-to-be-identified causal mechanistic interactions. That is, applying the knowledge-based vision approach in the understanding of evolved systems (machines or animals) may well lead to theories and models that are internally consistent, computationally plausible, and entirely wrong

On the isospin dependence of the mean spin-orbit field in nuclei

By the use of the latest experimental data on the spectra of $^{133}$Sb and $^{131}$Sn and on the analysis of properties of other odd nuclei adjacent to doubly magic closed shells the isospin dependence of a mean spin-orbit potential is defined. Such a dependence received the explanation in the framework of different theoretical approaches.Comment: 52 pages, Revtex, no figure

Lattice-Boltzmann and finite-difference simulations for the permeability for three-dimensional porous media

Numerical micropermeametry is performed on three dimensional porous samples having a linear size of approximately 3 mm and a resolution of 7.5 $\mu$m. One of the samples is a microtomographic image of Fontainebleau sandstone. Two of the samples are stochastic reconstructions with the same porosity, specific surface area, and two-point correlation function as the Fontainebleau sample. The fourth sample is a physical model which mimics the processes of sedimentation, compaction and diagenesis of Fontainebleau sandstone. The permeabilities of these samples are determined by numerically solving at low Reynolds numbers the appropriate Stokes equations in the pore spaces of the samples. The physical diagenesis model appears to reproduce the permeability of the real sandstone sample quite accurately, while the permeabilities of the stochastic reconstructions deviate from the latter by at least an order of magnitude. This finding confirms earlier qualitative predictions based on local porosity theory. Two numerical algorithms were used in these simulations. One is based on the lattice-Boltzmann method, and the other on conventional finite-difference techniques. The accuracy of these two methods is discussed and compared, also with experiment.Comment: to appear in: Phys.Rev.E (2002), 32 pages, Latex, 1 Figur

Analytical solutions of the lattice Boltzmann BGK model

Analytical solutions of the two dimensional triangular and square lattice Boltzmann BGK models have been obtained for the plain Poiseuille flow and the plain Couette flow. The analytical solutions are written in terms of the characteristic velocity of the flow, the single relaxation time $\tau$ and the lattice spacing. The analytic solutions are the exact representation of these two flows without any approximation.Comment: 10 pages, no postscript figure provide

Beat-wave generation of plasmons in semiconductor plasmas

It is shown that in semiconductor plasmas, it is possible to generate large amplitude plasma waves by the beating of two laser beams with frequency difference close to the plasma frequency. For narrow gap semiconductors (for example n-type InSb), the system can simulate the physics underlying beat wave generation in relativistic gaseous plasmas.Comment: 11 pages, LaTex, no figures, no macro