Empower(ed) Families: Supportive Treatment for Caregiver Burnout for Parents of Adolescents with Eating Disorders

Graduate Theoretical Proposa

The Creative Arts Personal Growth Group for Eating Disorder Recovery: An Embodiment-Focused Feminist Phenomenological Study

Eating disorders are complex mental and physical health disorders that impact every area of one’s life, and standard treatment protocols often fail to meet the multifaceted needs of eating disorder recovery. Studies indicate that relapse rates remain high following standard treatment and demonstrates that treatment often reinforces the body-centric and behavioral values of the disorder. Using the theoretical framework of feminist phenomenological lens and the hermeneutic phenomenological approach for data analysis, this study explored the use of the Creative Arts Personal Growth Group for Eating Disorder Recovery (CAPG-E), a group counseling protocol for eating disorder treatment that focuses on decreasing the impact of shame and fear while increasing positive experiences of embodiment. The eight-week protocol incorporates creative arts interventions with grounding skills, psychoeducation, self-compassion, and shame exposures in a setting that promotes safety and acceptance. This study explored the lived experiences of the six group members who served as co-researchers in exploring the CAPG-E components and processes that co-researchers identified as helpful and meaningful, reducing fear and shame, and contributing to positive changes in the experience of embodiment. Results indicated that the components and processes of the pilot CAPG-E group were effective in meeting these goals. Findings were discussed in light of the extant literature. Implications for social change and recommendations for further study were identified

Dynamic landscape and regulation of RNA editing in mammals

Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering selected nucleotides in RNA molecules1. Although many editing sites have recently been discovered2,3,4,5,6,7, the extent to which most sites are edited and how the editing is regulated in different biological contexts are not fully understood8,9,10. Here we report dynamic spatiotemporal patterns and new regulators of RNA editing, discovered through an extensive profiling of A-to-I RNA editing in 8,551 human samples (representing 53 body sites from 552 individuals) from the Genotype-Tissue Expression (GTEx) project and in hundreds of other primate and mouse samples. We show that editing levels in non-repetitive coding regions vary more between tissues than editing levels in repetitive regions. Globally, ADAR1 is the primary editor of repetitive sites and ADAR2 is the primary editor of non-repetitive coding sites, whereas the catalytically inactive ADAR3 predominantly acts as an inhibitor of editing. Cross-species analysis of RNA editing in several tissues revealed that species, rather than tissue type, is the primary determinant of editing levels, suggesting stronger cis-directed regulation of RNA editing for most sites, although the small set of conserved coding sites is under stronger trans-regulation. In addition, we curated an extensive set of ADAR1 and ADAR2 targets and showed that many editing sites display distinct tissue-specific regulation by the ADAR enzymes in vivo. Further analysis of the GTEx data revealed several potential regulators of editing, such as AIMP2, which reduces editing in muscles by enhancing the degradation of the ADAR proteins. Collectively, our work provides insights into the complex cis- and trans-regulation of A-to-I editing

Proceedings of the 4th World Conference on Research Integrity

CITATION: O’Brien, S. P., et al. 2016. Proceedings of the 4th World Conference on Research Integrity. Research Integrity and Peer Review, 1:9, doi:10.1186/s41073-016-0012-9.The original publication is available at https://researchintegrityjournal.biomedcentral.comThese Proceedings contain the abstracts of the presentations given at the 4th World Conference in concurrent sessions, partner symposia, and poster sessions. Also included are summaries of the discussions in three focus tracks, which allowed delegates to consider and work on questions about the roles of funders, institutions, and countries in improving research systems and strengthening research integrity. Videos of the plenary presentations are available at the conference website (www.wcri2015.org).https://researchintegrityjournal.biomedcentral.com/articles/10.1186/s41073-016-0012-