8,415 research outputs found
Intensifying agricultural sustainability: an analysis of impacts and drivers in the development of âbright spotsâ
Food security / Farming systems / Sustainable agriculture / Productivity / Investment / Thailand / Palestine / Latin America / Africa
Foetal H-2Kb-tsA58 Transgenic Mouse Tissue Develops Normally When Grafted to Adult Mouse Brain
Space Weathering of Ordinary Chondrite Parent Bodies, Its Impact on the Method of Distinguishing H, L, and LL Types and Implications for Itokawa Samples Returned by the Hayabusa Mission
As the most abundance meteorites in our collections, ordinary chondrites potentially have very important implications on the origin and formation of our Solar System. In order to map the distribution of ordinary chondrite-like asteroids through remote sensing, the space weathering effects of ordinary chondrite parent bodies must be addressed through experiments and modeling. Of particular importance is the impact on distinguishing different types (H/L/LL) of ordinary chondrites. In addition, samples of asteroid Itokawa returned by the Hayabusa spacecraft may re~ veal the mechanism of space weathering on an LLchondrite parent body. Results of space weathering simulations on ordinary chondrites and implications for Itokawa samples are presented here
Reflections of a âlate-careerâ early-career researcher: An account of practice
This account of practice describes the journey of an âaccidental academicâ through the Doctoral programme in Business Administration. It reflects on her experience of action learning and lessons learned to better embed action learning in future DBA teaching and assessment. The account is told from the perspective of a mature student straddling business and academic interests. DBA students represent a mature cohort with significant business experience and responsibility. As such, they have an implicit understanding of action learning. Action learning for these individuals should be re-activated rather than re-learned for their doctoral studies. Suggestions are made for improving the utility of action learning for DBA students and their willing engagement in the action learning process
A Collaborative Web-Based Approach to Planning Research, Integration, and Testing Using a Wiki
The National Aeronautics and Space Administration Integrated Vehicle Health Management program touches on many different research areas while striving to enable the automated detection, diagnosis, prognosis, and mitigation of adverse events at the aircraft and system level. At the system level, the research focus is on the evaluation of multidisciplinary integrated methods, tools, and technologies for achieving the program goal. The participating program members form a diverse group of government, industry, and academic researchers. The program team developed the Research and Test Integration Plan in order to track significant test and evaluation activities, which are important for understanding, demonstrating, and communicating the overall project state and project direction. The Plan is a living document, which allows the project team the flexibility to construct conceptual test scenarios and to track project resources. The Plan also incorporates several desirable feature requirements for Plan users and maintainers. A wiki has proven to be the most efficient and effective means of implementing the feature requirements for the Plan. The wiki has proven very valuable as a research project management tool, and there are plans to expand its scope
Fifty-kDa Hyaluronic Acid Upregulates Some Epidermal Genes without Changing TNF-α Expression in Reconstituted Epidermis
Background: Due to its strong water binding potential, hyaluronic acid (HA) is a well-known active ingredient for cosmetic applications. However, based on its varying molecular size, skin penetration of HA may be limited. Recent studies have demonstrated that low-molecular-weight HA (LMW HA) may show a certain proinflammatory activity. We thus aimed to characterize an LMW-sized HA molecule that combines strong anti-aging abilities with efficient skin penetration but lacks potential proinflammatory effects. Methods: Total RNA and total protein were isolated from reconstituted human epidermis following incubation with HAs of various molecular weights (20, 50, 130, 300, 800 and 1,500 kDa). Tumor necrosis factor-alpha expression was determined using quantitative PCR. Genonnic and proteomic expression of various junctional proteins was determined using Affymetrix and common Western blotting techniques. Results: LMW HA of approximately 50 kDa did not significantly alter tumor necrosis factor-alpha expression compared to 20-kDa HA, but revealed significantly higher skin penetration rates than larger sized HA associated with increased expression of genes and proteins known to be involved in tight junction formation and keratinocyte cohesion. Conclusion: LMW HA of approximately 50 kDa shows better penetration abilities than larger-sized HA. In addition, LMW HA influences the expression of various genes including those contributing to keratinocyte differentiation and formation of intercellular tight junction complexes without showing proinflammatory activity. These observations contribute to current knowledge on the effects of LMW HA on keratinocyte biology and cutaneous physiology. Copyright (C) 2011 S. Karger AG, Base
Narrow Line Cooling and Momentum-Space Crystals
Narrow line laser cooling is advancing the frontier for experiments ranging
from studies of fundamental atomic physics to high precision optical frequency
standards. In this paper, we present an extensive description of the systems
and techniques necessary to realize 689 nm 1S0 - 3P1 narrow line cooling of
atomic 88Sr. Narrow line cooling and trapping dynamics are also studied in
detail. By controlling the relative size of the power broadened transition
linewidth and the single-photon recoil frequency shift, we show that it is
possible to continuously bridge the gap between semiclassical and quantum
mechanical cooling. Novel semiclassical cooling process, some of which are
intimately linked to gravity, are also explored. Moreover, for laser
frequencies tuned above the atomic resonance, we demonstrate momentum-space
crystals containing up to 26 well defined lattice points. Gravitationally
assisted cooling is also achieved with blue-detuned light. Theoretically, we
find the blue detuned dynamics are universal to Doppler limited systems. This
paper offers the most comprehensive study of narrow line laser cooling to date.Comment: 14 pages, 19 figure
- âŠ