Echoes of the electroweak phase transition: discovering a second Higgs doublet through A0 → ZH0

The existence of a second Higgs doublet in nature could lead to a cosmological first-order electroweak phase transition and explain the origin of the matter-antimatter asymmetry in the Universe. We obtain the spectrum and properties of the new scalars H0, A0, and H� that signal such a phase transition and show that the observation of the decay A0 → ZH0 at LHC would be a “smoking gun” signature of these scenarios. We analyze the LHC search prospects for this decay in the llbb¯ and llWþW− final states, arguing that current data may be sensitive to this signature in the former channel as well as there being great potential for a discovery in either channel at the very early stages of the 14 TeV run

Bisphosphonate inhibits the expression of cyclin A2 at the transcriptional level in normal human oral keratinocytes.

Nitrogen-containing bisphosphonates (N-BPs) are the most widely used anti-resorptive agents in the treatment of bone-related diseases. N-BPs inhibit bone resorption by specifically targeting osteoclasts, bone-resorbing cells. However, soft tissue toxicity, such as oral or gastrointestinal (GI) ulcerations has frequently been reported in N-BP users, suggesting that N-BPs may also directly target cells other than osteoclasts. Previously, we reported that BPs inhibit proliferation without inducing the apoptosis of normal human oral keratinocytes (NHOKs). However, the molecular mechanisms through which N-BPs inhibit the proliferation of NHOKs are not yet fully understood. In this study, we performed gene expression profiling in N-BP-treated NHOKs and identified cyclin A2 as one of the most commonly downregulated genes. When the NHOKs were treated with N-BPs, we found that the level of cyclin A2 was suppressed in a dose- and time-dependent manner. In addition, the protein level of cyclin A2 was also significantly lower in oral epithelial cells in N-BP-treated oral mucosal tissue constructs. Cyclin A2 promoter reporter assay revealed that N-BPs inhibited the luciferase activity, indicating that the inhibition of cyclin A2 expression occurs at the transcriptional level. Furthermore, N-BPs did not alter the expression of cyclin A2 in normal human oral fibroblasts (NHOFs), suggesting that the effect of N-BPs on cyclin A2 expression may be cell-type specific. Thus, the findings of our study demonstrate that the inhibition of NHOK proliferation by N-BPs is mediated, at least in part, by the suppression of cyclin A2 expression at the transcriptional level, which may explain the underlying mechanisms of soft tissue toxicity by N-BPs

Energy loss mechanism for suspended micro- and nanoresonators due to the Casimir force

A so far not considered energy loss mechanism in suspended micro- and nanoresonators due to noncontact acoustical energy loss is investigated theoretically. The mechanism consists on the conversion of the mechanical energy from the vibratory motion of the resonator into acoustic waves on large nearby structures, such as the substrate, due to the coupling between the resonator and those structures resulting from the Casimir force acting over the separation gaps. Analytical expressions for the resulting quality factor Q for cantilever and bridge micro- and nanoresonators in close proximity to an underlying substrate are derived and the relevance of the mechanism is investigated, demonstrating its importance when nanometric gaps are involved

Transition from Mott insulator to superconductor in GaNb4_{4}Se8_{8} and GaTa4_{4}Se8_{8} under high pressure

Electronic conduction in GaM$_{4}$Se$_{8}$ (M=Nb;Ta) compounds with the fcc GaMo$_{4}$S$_{8}$-type structure originates from hopping of localized unpaired electrons (S=1/2) among widely separated tetrahedral M$_{4}$ metal clusters. We show that under pressure these systems transform from Mott insulators to a metallic and superconducting state with T$_{C}$=2.9 and 5.8K at 13 and 11.5GPa for GaNb$_{4}$Se$_{8}$ and GaTa$_{4}$Se$_{8}$, respectively. The occurrence of superconductivity is shown to be connected with a pressure-induced decrease of the MSe$_{6}$ octahedral distortion and simultaneous softening of the phonon associated with MSe-bonds.Comment: 10 pages, 5 figure

Patients' views on improving sickle cell disease management in primary care: focus group discussion.

OBJECTIVES: To assess sickle cell disease (SCD) patient and carer perspectives on the primary care services related to SCD that they receive from their general practitioner (GP). DESIGN: A focus group discussion was used to elicit the views of patients about the quality of care they receive from their primary health-care providers and what they thought was the role of primary care in SCD management. The focus group discussion was video recorded. The recording was then examined by the project team and recurring themes were identified. A comparison was made with notes made by two scribes also present at the discussion. SETTING: Sickle Cell Society in Brent, UK. PARTICIPANTS: Ten participants with SCD or caring for someone with SCD from Northwest London, UK. MAIN OUTCOME MEASURES: Patients perceptions about the primary care services they received, and a list of key themes and suggestions. RESULTS: Patients and carers often bypassed GPs for acute problems but felt that GPs had an important role to play around repeat prescriptions and general health care. These service users believed SCD is often ignored and deemed unimportant by GPs. CONCLUSION: Participants wanted the health service to support primary health-care providers to improve their knowledge and understanding of SCD. Key themes and suggestions from this focus group have been used to help develop an educational intervention for general practice services that will be used to improve SCD management in primary care

Effects of high-intensity interval walking training on physical fitness and blood pressure in middle-aged and older people

Reproduced from Mayo Clin Proc., with permission), permission is hereby granted to place a pdf of Nemoto, K et al. Effects of high-intensity interval walking training on physical fitness and blood pressure in middle-aged and older people. Mayo Clin Proc. 82 (7):803-811 into the institutional repository of Shinshu University at https://soar-ir.shinshu-u.ac.jp/ArticleMAYO CLINIC PROCEEDINGS. 82(7): 803-811 (2007)journal articl

Effects of poultry manure supplemented by NPK 15:15:15 fertilizer on cucumber (Cucumis sativus L.) production in Port Harcourt (Nigeria)

Cucumber (Cucumis sativus L.) is a newly introduced exotic crop in Port Harcourt (Nigeria) that is in high demand, but due to inadequate production and distance from areas of mass production, the supply is highly limited. Replicate field plots were employed in the experiments aimed at determining the effects of poultry manure supplemented by NPK 15:15:15 on cucumber for a period of two seasons. Three poultry manure (PM) levels; 0, 5 and 10 t/ha, two levels of NPK 15:15:15 60 and 120 kg/ha and the combination of the different levels of poultry manure and NPK fertilizer were used, respectively. The pertinent growth, yield and soil parameters were then determined. Results of the analysis show that various combined nutrients treated plots significantly influenced vine length and leaf area than the plots that were treated with single nutrients and control. The best result of the fruit yield were obtained from plots treated with 5 t/ha of poultry manure supplemented with 120 kg/ha of NPK and 10 t/ha PM supplemented with 60 kg/ha NPK (18.24 and 19.30 t/ha) for wet and dry seasons, respectively. Soil analysis result show that treatments applied at various levels increased soil fertility. The result of the study showed that the best crop yield was obtained on cucumber during dry season farming.Keywords: Cucumber, vine length, leaf area, fruit yield, NPK 15:15:15, poultry manure, exotic cro