Політичний іслам – маркер кризового суспільства

В статье Н.Кирюшко «Политический ислам - маркер кризисного общества» анализируются процессы политизации и радикализации ислама в мире и в Украине в частности; раскрываются предпосылки, причины и возможные последствия деятельности религиозно-политического движения «Хизб ат- Тахрир» на территории Украины. Ключевые слова: политический ислам, политизация ислама, исламская политика, религиозная партия «Хизб ат-Тахрір», мусульманская среда.In the article of M.Kiryushkо «Political Islam is a marker of crisis society» the processes of politization and radikalization of Islam in the world as a whole and in Ukraine in particular are analysed. The author also defines pre-conditions, reasons and possible consequences of activity of the religious and political movement of «Khizb ut-Takhrir» in Ukraine. Keywords: political islam, politization of Islam, Islam policy, religious party of «Khizb ut-Takhrir», Muslim society

Regulation of Mesodermal Differentiation of Mouse Embryonic Stem Cells by Basement Membranes

This research was originally published in the Journal of Biological Chemistry. Hironobu Fujiwara, Yoshitaka Hayashi, Noriko Sanzen, Reiko Kobayashi, Charles N. Weber, Tomomi Emoto, Sugiko Futaki, Hitoshi Niwa, Patricia Murray, David Edgar and Kiyotoshi Sekiguchi. Regulation of Mesodermal Differentiation of Mouse Embryonic Stem Cells by Basement Membranes. J. Biol. Chem. 2007; 282: 29701–29711 © the American Society for Biochemistry and Molecular Biolog

The Japanese space gravitational wave antenna; DECIGO

DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future Japanese space gravitational wave antenna. DECIGO is expected to open a new window of observation for gravitational wave astronomy especially between 0.1 Hz and 10 Hz, revealing various mysteries of the universe such as dark energy, formation mechanism of supermassive black holes, and inflation of the universe. The pre-conceptual design of DECIGO consists of three drag-free spacecraft, whose relative displacements are measured by a differential Fabry– Perot Michelson interferometer. We plan to launch two missions, DECIGO pathfinder and pre- DECIGO first and finally DECIGO in 2024

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

青年期の親への愛着によるソーシャル・サポート,サポート希求の差異とそのバランスの検討 : 父親,母親,友人に焦点をあてて

The aims of this study were to examine the effects of attachment to parents on support seeking from significant others, as well as the social support actually received from these significant others, and also, to examine the balance between received support and support seeking. The main results were as follows. Participants who were identified to be of the Secure Type received much social support from their fathers and mothers, and also sought for much support from the two. They also revealed a tendency receive more support from their mother than what they sought from her. Participants who were characteristic of the Preoccupied Type received and sought a lot of support from their mothers, receiving little from their fathers, while demanding a lot from them. They also showed a tendency to seek more support from their fathers and mothers than they received. Those who were a Dismissing Type received little support from their father and mother, while also seeking little. They typically sought less support from their fathers and mothers than what they received from them. Finally, the Apprehensive Type reported little support from their father and mother, while seeking little support from them. They showed no imbalance between support received nor sought from their father and mother. Incidentally, the Secure Type received more social support from their friends, and sought more from them than the Apprehensive Type. However, there were no differences between attachment styles on the imbalance of social support received and sought.国立情報学研究所で電子化したコンテンツを使用している