Psychological approaches and new therapies to the choices of the Morris syndrome patient: Abordagens psicológicas e novas terapêuticas perante as escolhas do paciente portador da Síndrome de Morris

Introduction: Complete Androgen Insensitivity Syndrome (SIAC) is an X-linked recessive disorder in which the patient has a female-phenotype XY karyotype. This is due to the insensitivity to androgens, including testosterone and DHT, by the abnormality or absence of androgen receptors.Objective: This study aims to address new therapies in the face of current choices in patients with Morris syndrome. Methods:The bibliographic survey was carried out between March and April 2021 from materials such as scientific articles and publications of the Brazilian Federation of Gynecology and Obstetrics Associations (Febrasgo), Revista Bioética, KargerPublishers, Publisher of Open Access Journals (MDPI), Unicamp's Repository of Scientific and Intellectual Production and Scielo's database. 17 articles were selected that corresponded to the proposed criteria for carrying out the work.Results:Due to male pseudohermaphroditism, the patient presents external female sexual organs, but internally, will have testicles. In addition, changes in external genitalia, breasts, stature, and significant hormonal changes can be seen. In short, the diagnosis is based on clinical presentation, laboratory and imaging tests in a woman with karyotype 46, XY, and may be confirmed by means of an analysis of the AR gene. During the choice of treatment, the main approach will be in relation to attribution of sex, adequate or not to external genitalia, hormone replacement, psychosexual outcome, ideal time for gonadectomy and genetic counseling. However, after diagnosis, psychological follow-up has a primary role in supporting patients and family members, as all the issues involved need to be addressed in clear dialog.Conclusions:Current patient choices bring us great challenges, especially when the choice is to take on the male karyotype. When one assumes the feminine one seems simpler, but the psychological question is also very challenging. This indicates that new strategies and a lot of multidisciplinary attention are needed for the treatment of these patients

Lentinoids A–D, New Natural Products Isolated from Lentinus strigellus

Four novel lentinoids (1–4), along with the known compounds striguellone A (5), isopanepoxydone (6) and panepoxydone (7), were isolated as part of our studies on Lentinus strigellus. The structures of 1–4 have been established by 1D- and 2D-NMR and MS analysis. Compounds (1–3) and (5–7) were tested against Listeria monocytogenes, Enterococcus faecalis, Pseudomonas aeruginosa and Klebsiella pneumoniae. These compounds showed inhibition diameters ranging from 7.5–9.5 mm, however, when the minimum inhibitory concentration (MIC) was determined, only compound 1 showed a significant activity of 200 μg/mL. Intermediates for the biosynthesis of the oxygenated cyclohexenyl derivatives isolated from lentinoid fungi (genera Lentinus and Panus) are proposed

Mycoleptodiscins A and B, Cytotoxic Alkaloids from the Endophytic Fungus <i>Mycoleptodiscus</i> sp. F0194

Two novel reddish-orange alkaloids, mycoleptodiscin A (<b>1</b>) and mycoleptodiscin B (<b>2</b>), were isolated from liquid cultures of the endophytic fungus <i>Mycoleptodiscus</i> sp. that had been isolated from <i>Desmotes incomparabilis</i> in Panama. Elucidation of their structures was accomplished using 1D and 2D NMR spectroscopy in combination with IR spectroscopic and MS data. These compounds are indole-terpenes with a new skeleton uncommon in nature. Mycoleptodiscin B (<b>2</b>) was active in inhibiting the growth of cancer cell lines with IC₅₀ values in the range 0.60–0.78 μM