Search for Coincident Gravitational Wave and Long Gamma-Ray Bursts from 4-OGC and the Fermi-GBM/Swift-BAT Catalog

The recent discovery of a kilonova associated with an apparent long-durationgamma-ray burst has challenged the typical classification that long gamma-raybursts originate from the core collapse of massive stars and short gamma-raybursts are from compact binary coalescence. The kilonova indicates a neutronstar merger origin and suggests the viability of gravitational-wave and longgamma-ray burst multimessenger astronomy. Gravitational waves play a crucialrole by providing independent information for the source properties. This workrevisits the archival 2015-2020 LIGO/Virgo gravitational-wave candidates fromthe 4-OGC catalog which are consistent with a binary neutron star or neutronstar-black hole merger and the long-duration gamma-ray bursts from theFermi-GBM and Swift-BAT catalogs. We search for spatial and temporalcoincidence with up to 10 s time lag between gravitational-wave candidates andthe onset of long-duration gamma-ray bursts. The most significant candidateassociation has only a false alarm rate of once every two years; given theLIGO/Virgo observational period, this is consistent with a null result. Wereport an exclusion distance for each search candidate for a fiducialgravitational-wave signal and conservative viewing angle assumptions.<br

Simulation of cholinergic and noradrenergic modulation of behavior in uncertain environments

Attention is a complex neurobiological process that involves rapidly and flexibly balancing sensory input and goal-directed predictions in response to environmental changes. The cholinergic and noradrenergic systems, which have been proposed to respond to expected and unexpected environmental uncertainty, respectively, play an important role in attention by differentially modulating activity in a multitude of cortical targets. Here we develop a model of an attention task that involves expected and unexpected uncertainty. The cholinergic and noradrenergic systems track this uncertainty and, in turn, influence cortical processing in five different, experimentally verified ways: (1) nicotinic enhancement of thalamocortical input, (2) muscarinic regulation of corticocortical feedback, (3) noradrenergic mediation of a network reset, (4) locus coeruleus (LC) activation of the basal forebrain (BF), and (5) cholinergic and noradrenergic balance between sensory input and frontal cortex predictions. Our results shed light on how the noradrenergic and cholinergic systems interact with each other and a distributed set of neural areas, and how this could lead to behavioral adaptation in the face of uncertainty

CA1-projecting subiculum neurons facilitate object-place learning.

Recent anatomical evidence suggests a functionally significant back-projection pathway from the subiculum to the CA1. Here we show that the afferent circuitry of CA1-projecting subicular neurons is biased by inputs from CA1 inhibitory neurons and the visual cortex, but lacks input from the entorhinal cortex. Efferents of the CA1-projecting subiculum neurons also target the perirhinal cortex, an area strongly implicated in object-place learning. We identify a critical role for CA1-projecting subicular neurons in object-location learning and memory, and show that this projection modulates place-specific activity of CA1 neurons and their responses to displaced objects. Together, these experiments reveal a novel pathway by which cortical inputs, particularly those from the visual cortex, reach the hippocampal output region CA1. Our findings also implicate this circuitry in the formation of complex spatial representations and learning of object-place associations

3-OGC: Catalog of gravitational waves from compact-binary mergers

We present the third Open Gravitational-wave Catalog (3-OGC) of compact-binary coalescences, based on the analysis of the public LIGO and Virgo data from 2015 through 2019 (O1, O2, O3a). Our updated catalog includes a population of 57 observations, including four binary black hole mergers that had not previously been reported. This consists of 55 binary black hole mergers and the two binary neutron star mergers GW170817 and GW190425. We find no additional significant binary neutron star or neutron star--black hole merger events. The most confident new detection is the binary black hole merger GW190925\_232845 which was observed by the LIGO Hanford and Virgo observatories with $\mathcal{P}_{\textrm{astro}} > 0.99$; its primary and secondary component masses are $20.2^{+3.9}_{-2.5} M_{\odot}$ and $15.6^{+2.1}_{-2.6} M_{\odot}$, respectively. We estimate the parameters of all binary black hole events using an up-to-date waveform model that includes both sub-dominant harmonics and precession effects. To enable deep follow-up as our understanding of the underlying populations evolves, we make available our comprehensive catalog of events, including the sub-threshold population of candidates, and the posterior samples of our source parameter estimates

Observation of a multimode quasi-normal spectrum from a perturbed black hole

We provide strong observational evidence for a multimode black hole ringdown spectrum, using the gravitational wave event GW190521. We show strong evidence for the presence of at least two ringdown modes, with a Bayes factor of $43.4^{+8.1}_{-6.8}$ preferring two modes over one. The dominant mode is the fundamental $\ell=m=2$ harmonic, and the sub-dominant mode corresponds to the fundamental $\ell=m=3$ harmonic. We estimate the redshifted mass and dimensionless spin of the final black hole as $332^{+31}_{-35}\,M_\odot$ and $0.871^{+0.052}_{-0.096}$ respectively. The detection of the two modes disfavors a binary progenitor with equal masses, and the mass ratio is constrained to $0.45^{+0.22}_{-0.29}$. General relativity predicts that the frequency and damping time of each mode in the spectrum depends only on two parameters, the black hole mass and angular momentum. Consistency between the different modes thus provides a test of general relativity. As a test of the black hole no-hair theorem, we constrain the fractional deviation of the sub-dominant mode frequency from the Kerr prediction to $\delta f_{330} = -0.010^{+0.073}_{-0.121}

Constraints on Gamma-ray Emission from the Galactic Plane at 300 TeV

We describe a new search for diffuse ultrahigh energy gamma-ray emission associated with molecular clouds in the galactic disk. The Chicago Air Shower Array (CASA), operating in coincidence with the Michigan muon array (MIA), has recorded over 2.2 x 10^{9} air showers from April 4, 1990 to October 7, 1995. We search for gamma rays based upon the muon content of air showers arriving from the direction of the galactic plane. We find no significant evidence for diffuse gamma-ray emission, and we set an upper limit on the ratio of gamma rays to normal hadronic cosmic rays at less than 2.4 x 10^{-5} at 310 TeV (90% confidence limit) from the galactic plane region: (50 degrees < l < 200 degrees); -5 degrees < b < 5 degrees). This limit places a strong constraint on models for emission from molecular clouds in the galaxy. We rule out significant spectral hardening in the outer galaxy, and conclude that emission from the plane at these energies is likely to be dominated by the decay of neutral pions resulting from cosmic rays interactions with passive target gas molecules.Comment: Astrophysical Journal, submitted, 11 pages, AASTeX Latex, 3 Postscript figure

4-OGC: Catalog of gravitational waves from compact-binary mergers

We present the fourth Open Gravitational-wave Catalog (4-OGC) of binary neutron star (BNS), binary black hole (BBH) and neutron star-black hole (NSBH) mergers. The catalog includes observations from 2015-2020 covering the first through third observing runs (O1, O2, O3a, O3b) of Advanced LIGO and Advanced Virgo. The updated catalog includes 7 BBH mergers which were not previously reported with high significance during O3b for a total of 94 observations: 90 BBHs, 2 NSBHs, and 2 BNSs. The most confident new detection, GW200318_191337, has component masses $49.1^{+16.4}_{-12.0}~M_{\odot}$ and $31.6^{+12.0}_{-11.6}~M_{\odot}$; its redshift of $0.84^{+0.4}_{-0.35}$ ($90\%$ credible interval) may make it the most distant merger so far. We provide reference parameter estimates for each of these sources using an up-to-date model accounting for instrumental calibration uncertainty. The corresponding data release also includes our full set of sub-threshold candidates

Use of electronic medical records (EMR) for oncology outcomes research: assessing the comparability of EMR information to patient registry and health claims data

Electronic medical records (EMRs) are used increasingly for research in clinical oncology, epidemiology, and comparative effectiveness research (CER)