CHEMICAL COMPOSITION AND HEPATOPROTECTIVE EFFECTS OF POLYPHENOLIC FRACTION FROM RIVEA HYPOCRATERIFORMIS IN PARACETAMOL INDUCED LIVER DAMAGE IN WISTAR ALBINO RATS

Objective: This study was designed to chemical composition and hepatoprotective effects of a polyphenolic fraction of aerial parts of R. hypocrateriformis (PPFRH). It was shown to exhibit strong in vitro lipid peroxidation and scavenging activity against hydroxyl radical.Methods: The chemical composition of a polyphenolic fraction of R. hypocrateriformis was analyzed by High-performance liquid chromatography method. Hepatocellular injuries induced by paracetamol were assessed by liver damage in Wistar albino rat; the hepatoprotective effect was evaluated by biochemical parameters in rat serum, antioxidant hydroxyl radical scavenging activity and lipid peroxidation in liver tissue.Results: The polyphenolic fraction of aerial parts of R. hypocrateriformis for lipid peroxidation is significantly (p<0.05). In the hepatoprotective activity of liver enzymes and hepatic necrosis were significantly (p<0.001) closer to paracetamol. The correlation coefficient between the hydroxyl scavenging radical and total phenolic and flavonoid contents were found to be R² = 0.9045 and R² = 0.8876 suggesting the contribution of phenolic and flavonoid compounds of the polyphenolic fraction of aerial parts of R. hypocrateriformis by 90% and 88% to its radical scavenging activity.Conclusion: The polyphenolic fraction of aerial parts of R. hypocrateriformis possesses a significant protective effect against acute hepatotoxicity induced by paracetamol and which may be due to the phenolic and flavonoid components

Neuroprotection Of Calotropis Procera Leaf Extract In Neuropathy Induced Rat Model

<p>Neurons are the fundamental units of the brain and nervous system, the cells responsible for receiving sensory input from external world. Neurological disabilities include a wide range of disorder, such as epilepsy learning disabilities, neuromuscular disorders, autism, attention deficit disorder, brain tumours and cerebral palsy. Neuroprotection is the ability for a therapy to prevent neuronal cell death by intervening in and inhibiting the pathogenetic cascade that results in cell dysfunction and eventual death. Numerous natural products, but primarily plant extracts, have been reported to be used in traditional medicine for neuroprotective, memory enhancing, and antiaging purposes. Calotropis Procrera known as "milkweeds "which comes under the family of Apocyanacece. Ethanolic extract of Calotrpis procera that contains active chemical constituents such as flavonoids, tannins, phenols show neuroprotective activity. In view of this, the present study was aimed to evaluate neuroprotective activity of ethanolic extract of leaves of Calotropis Procrea in neuropathy induced rat model.</p&gt