Development of displacement- and frequency-noise-free interferometer in 3-D configuration for gravitational wave detection

The displacement- and frequency-noise-free interferometer (DFI) is a multiple laser interferometer array for gravitational wave detection free from both the displacement noise of optics and laser frequency noise. So far, partial experimental demonstrations of DFI have been done in 2-D table top experiments. In this paper, we report the complete demonstration of a 3-D DFI. The DFI consists of four Mach-Zehnder interferometers with four mirrors and two beamsplitters. The displacement noises both of mirrors and beamsplitters were suppressed by up to 40 dB. The non-vanishing DFI response to a gravitational wave was successfully confirmed using multiple electro-optic modulators and computing methods

Demonstration of displacement-noise-free interferometry using bi-directional Mach–Zehnder interferometers

We have demonstrated displacement- and frequency-noise-free laser interferometry (DFI) by partially implementing a recently proposed optical configuration using bi-directional Mach–Zehnder interferometers (MZIs). This partial implementation, the minimum necessary to be called DFI, has confirmed the essential feature of DFI: the combination of two MZI signals can be carried out in a way that cancels the displacement noise of the mirrors and beam splitters while maintaining gravitational-wave signals. The attained maximum displacement noise suppression was 45 dB

The experimental plan of displacement- and frequency-noise free laser interferometer

We present the partial demonstration of displacement- and laser-noise free interferometer (DFI) and the next experimental plan to examine the complete configuration. A part of the full implementation of DFI has been demonstrated to confirm the cancellation of beamsplitter displacements. The displacements were suppressed by about two orders of magnitude. The aim of the next experiment is to operate the system and to confirm the cancellation of all displacement noises, while the gravitational wave (GW) signals survive. The optical displacements will be simulated by electro-optic modulators (EOM). To simulate the GW contribution to laser lights, we will use multiple EOMs

Temperature rise measurement for power-loss comparison of an aluminum electrolytic capacitor between sinusoidal and square-wave current injections

DC-link capacitors are a major factor of degrading reliability of power electric converters because they usually have a shorter lifetime and higher failure rate than those of semiconductor devices or magnetic devices. Characteristics of the capacitors are usually evaluated by a single sinusoidal current waveform. However, actual current flowing out of the converter into the capacitor is a modulated square current waveform. This paper provides experimental comparison of the power loss dissipated in an aluminum electrolytic capacitor between sinusoidal and square-wave current injections. Power loss is estimated by temperature rise of the capacitor. Experimental results confirm that power losses of the square-wave current injection were always lower than those of the sinusoidal current injection by 10–20%. Moreover, the power losses of the square-wave current injection can be estimated by a synthesis of fundamental and harmonic currents based on the Fourier series expansion, which brings a high accuracy less than 1% when more than fifth harmonic current is introduced. This comparison will be useful for estimating power loss and life time of electrolytic capacitors

Identification of Selective Agonists and Antagonists to G Protein-Activated Inwardly Rectifying Potassium Channels: Candidate Medicines for Drug Dependence and Pain

G protein-activated inwardly rectifying K+ (GIRK) channels have been known to play a key role in the rewarding and analgesic effects of opioids. To identify potent agonists and antagonists to GIRK channels, we examined various compounds for their ability to activate or inhibit GIRK channels. A total of 503 possible compounds with low molecular weight were selected from a list of fluoxetine derivatives at Pfizer Japan Inc. We screened these compounds by a Xenopus oocyte expression system. GIRK1/2 and GIRK1/4 heteromeric channels were expressed on Xenopus laevis oocytes at Stage V or VI. A mouse IRK2 channel, which is another member of inwardly rectifying potassium channels with similarity to GIRK channels, was expressed on the oocytes to examine the selectivity of the identified compounds to GIRK channels. For electrophysiological analyses, a two-electrode voltage clamp method was used. Among the 503 compounds tested, one compound and three compounds were identified as the most effective agonist and antagonists, respectively. All of these compounds induced only negligible current responses in the oocytes expressing the IRK2 channel, suggesting that these compounds were selective to GIRK channels. These effective and GIRK-selective compounds may be useful possible therapeutics for drug dependence and pain