高齢者における血中好酸球数高値と気流閉塞は、喘息の新規発症を予測し得る：ながはま疫学研究

京都大学新制・課程博士博士(医学)甲第25193号医博第5079号京都大学大学院医学研究科医学専攻(主査)教授 山本 洋介, 教授 中山 健夫, 教授 江木 盛時学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA

In Situ Surface Roughness Analysis of Electrodeposited Co Films in an Ionic Liquid Using Electrochemical Surface Plasmon Resonance: Effect of Leveling Additives

The effect of two leveling additives, thiourea (TU) and coumarin (CM), on cobalt electrodeposition process in an ionic liquid (IL), 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)amide (C4mimTFSA), at the gold surface has been analyzed in situ using electrochemical surface plasmon resonance (ESPR), in which the SPR resonance angle (Δθ) has been recorded simultaneously with cyclic voltammograms. The two additives show Δθ behaviors different from the additive-free case and from each other. In the case of TU, the positive Δθ shift due to Co cathodic deposition is larger than the additive-free case. Even after the subsequent negative Δθ shift due to Co anodic dissolution, Δθ remains positive not returning to the original value. This indicates that the dissolution of gold facilitated by TU roughens the surface of the gold electrode. In contrast, in the case of CM, the positive Δθ shift due to Co cathodic deposition is smaller than the additive-free case. A model analysis using Fresnel reflectivity has revealed that CM actually smooths the surface of the Co film even in the initial process of the electrodeposition. These findings illustrate that ESPR can sense in situ the surface roughness change during electrodeposition on the order of Å

Privacy-Preserving Hierarchical Anonymization Framework over Encrypted Data

Smart cities, which can monitor the real world and provide smart services in a variety of fields, have improved people's living standards as urbanization has accelerated. However, there are security and privacy concerns because smart city applications collect large amounts of privacy-sensitive information from people and their social circles. Anonymization, which generalizes data and reduces data uniqueness is an important step in preserving the privacy of sensitive information. However, anonymization methods frequently require large datasets and rely on untrusted third parties to collect and manage data, particularly in a cloud environment. In this case, private data leakage remains a critical issue, discouraging users from sharing their data and impeding the advancement of smart city services. This problem can be solved if the computational entity can perform the anonymization process without obtaining the original plain text. This study proposed a hierarchical k-anonymization framework using homomorphic encryption and secret sharing composed of two types of domains. Different computing methods are selected flexibly, and two domains are connected hierarchically to obtain higher-level anonymization results in an efficient manner. The experimental results show that connecting two domains can accelerate the anonymization process, indicating that the proposed secure hierarchical architecture is practical and efficient.Comment: 8 pages, 12 figures, submitted to IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS and under revie

Search for Tetraneutron by Pion Double Charge Exchange Reaction at J-PARC

Tetraneutron ($^4n$) has come back in the limelight, because of recent observation of a candidate resonant state at RIBF. We propose to investigate the pion double charge exchange (DCX) reaction, i.e. $^4\mathrm{He}({\pi}^- , {\pi}^+)$, as an alternative way to populate tetraneutron. An intense ${\pi}^-$ beam with the kinetic energy of ~850 MeV, much higher than that in past experiments at LAMPF and TRIUMF, will open up a possibility to improve the experimental sensitivity of the formation cross section, which will be much smaller than hitherto known DCX cross sections such as $^9\mathrm{Be}({\pi}^-, {\pi}^+)^9\mathrm{He}\ (g.s.)$.Comment: 4 pages, 1 figure; proceedings of the 14th International Conference on Meson-Nucleon Physics and the Structure of the Nucleon (MENU2016), Kyoto, Japan, 25-30 July 201

Interfacial Structure at the Quaternary Ammonium-Based Ionic Liquids vertical bar Gold Electrode Interface Probed by Surface-Enhanced Infrared Absorption Spectroscopy: Anion Dependence of the Cationic Behavior

The interfacial structure at the quaternary ammonium-based ionic liquids(ILs)|gold(Au) electrode interface has been studied using surface-enhanced infrared absorption spectroscopy (SEIRAS). Four anions, bis(perfluoroalkanesulfonyl)amide (CₙCₙN⁻; n = 0, 1, 2, 4), have been combined with a quaternary ammonium cation, trioctylmethylammonium (N₈₈₈₁⁺), to investigate the influence of the perfluoroalkyl chain length of the anion on the behavior of the quaternary ammonium cation at the interface. In addition, to investigate the effect of the alkyl chain length of the quaternary ammonium cations on the cationic behavior, we have also combined a cation with a shorter alkyl chain, tributylmethylammonium (N₄₄₄₁⁺) with C₁C₁N⁻. Thus, we have performed SEIRAS measurements at the Au interface of five ILs: [N₈₈₈₁⁺][CₙCₙN⁻] (n = 0, 1, 2, 4) and [N₄₄₄₁⁺][C₁C₁N⁻]. The four CH stretching bands originating from the quaternary ammonium cations have been individually analyzed, enabling us to reveal the behavior of the quaternary ammonium cations at the interface. The cationic behavior is found to dramatically depend not only on the alkyl chain length but also on the perfluoroalkyl chain length of the counterion. For [N₈₈₈₁⁺][C₄C₄N⁻] and [N₈₈₈₁⁺][C₂C₂N⁻], octyl chains of N₈₈₈₁⁺cannot reach the Au electrode surface at positive potentials because the bulky anions in the first ionic layer on the electrode surface block the approach. Conversely, for ILs with the smaller anions ([N₈₈₈₁⁺][C₁C₁N⁻] and [N₈₈₈₁⁺][C₀C₀N⁻]), octyl chains of N₈₈₈₁⁺ can penetrate into a space in the first ionic layer of small anions. The butyl chains of N₄₄₄₁⁺ in [N₄₄₄₁⁺][C₁C₁N⁻] cannot reach the surface at positive potentials even across the first ionic layer of the small anions because of their relatively short alkyl chain length

Sensitivity of the deeply bound pionic atoms to the pion-nucleon sigma term σπN\sigma_{\pi N}

We discuss the sensitivity of the observables of the deeply bound pionic atoms to the pion-nucleon sigma term $\sigma_{\pi N}$ to investigate the possibility of the precise determination of the value of $\sigma_{\pi N}$ by the accurate data of the deeply bound pionic atoms expected to be obtained at RIBF/RIKEN. We evaluate that the 1 MeV variation of the $\sigma_{\pi N}$ value $\Delta \sigma_{\pi N} = 1$ MeV causes the shift of the binding energy $|\Delta B_\pi (1s)| = 5 \sim 7.5$ keV of the 1$s$ pionic atoms in Sn isotopes for the cases considered in this article. The width of the $1s$ state in the light Sn isotopes has good sensitivity to the $\sigma_{\pi N}$ value, too. We also study the sensitivity of the formation spectra of the deeply bound pionic atoms to the value of the $\sigma_{\pi N}$ term. The combined analyses of the observables of the deeply bound pionic atoms are found to be helpful to determine the $\sigma_{\pi N}$ term precisely. One of the interesting combination of the observables is the energy gap of the 1$s$ and $2p$ states ($B_{\pi}(1s) - B_\pi(2p)$) which experimental error is significantly smaller than that of the absolute value of the binding energy itself of each state. The expected experimental error of the energy gap is $10 \sim 15$ keV in Sn region which corresponds to the uncertainty of the $\sigma_{\pi N}$ value around 3 MeV in our evaluation.Comment: 9 pages, 8 figures, 3 table

The effect of omega-3 fatty acids on psychophysiological assessment for the secondary prevention of posttraumatic stress disorder: an open-label pilot study.

Our recent pilot study has shown that the supplementation of omega-3 fatty acids (fish oil) immediately after a traumatic event may be effective toward the secondary prevention of post-traumatic disorder (PTSD). To lay the groundwork for addressing the mechanism by which omega-3 fatty acids can prevent PTSD, we analyzed its psychophysiological data. The psychophysiological data included heart rate, skin conductance, and continuous blood pressure during patient subjection to startling tones and idiographic trauma-related cues. Of the 8 patients, 1 met the diagnostic criteria for PTSD. Compared to the seven patients without PTSD, one patient with PTSD showed relatively large reactivity to the startle tones. In contrast, this patient did not show large reactivity to the trauma-related cue during script-driven imagery. The combination of psychophysiological measurements in our randomized control trial should shed light on the underlying mechanisms by which omega-3 fatty acids can prevent PTSD

Spectroscopy of eta'-nucleus bound states at GSI-SIS

The eta' meson mass may be reduced due to partial restoration of chiral symmetry. If this is the case, an eta'-nucleus system may form a nuclear bound state. We plan to carry out a missing-mass spectroscopy with the 12C(p,d) reaction at GSI-SIS. Peak structures corresponding to such a bound state may be observed even in an inclusive measurement, if the decay width is narrow enough.Comment: 4 pages, 2 figures, to appear in the proceedings of MESON2012 (12th International Workshop on Meson Production, Properties and Interaction), Krakow, Polan

Feasibility Study of Observing eta' Mesic Nuclei with (p,d) Reaction

A novel method is proposed to measure eta'(958) meson bound states in 11C nuclei by missing mass spectroscopy of the 12C(p,d) reaction near the eta' production threshold. It is shown that peak structures will be observed experimentally in an inclusive measurement in case that the in-medium eta' mass reduction is sufficiently large and that the decay width of eta' mesic states is narrow enough. Such a measurement will be feasible with the intense proton beam supplied by the SIS synchrotron at GSI combined with the good energy resolution of the fragment separator FRS.Comment: 12 pages, 6 figures, accepted for publication in Progress of Theoretical Physic

The Molecular Outflows in the rho Ophiuchi Main Cloud: Implications For Turbulence Generation

We present the results of CO (J=3-2) and CO (J=1-0) mapping observations toward the active cluster forming clump, L1688, in the rho Ophiuchi molecular cloud. From the CO (J=3-2) and CO (J=1-0) data cubes, we identify five outflows, whose driving sources are VLA 1623, EL 32, LFAM 26, EL 29, and IRS 44. Among the identified outflows, the most luminous outflow is the one from the prototypical Class 0 source, VLA 1623. We also discover that the EL 32 outflow located in the Oph B2 region has very extended blueshifted and redshifted lobes with wide opening angles. This outflow is most massive and have the largest momentum among the identified outflows in the CO (J=1-0) map. We estimate the total energy injection rate due to the molecular outflows identified by the present and previous studies to be about 0.2 L_solar, larger than or at least comparable to the turbulence dissipation rate [~(0.03 - 0.1) L_solar]. Therefore, we conclude that the protostellar outflows are likely to play a significant role in replenishing the supersonic turbulence in this clump.Comment: 37 pages, 9 figures, accepted for publication in The Astrophysical Journa