The InterLACE study: design, data harmonization and characteristics across 20 studies on women's health

The International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE) project is a global research collaboration that aims to advance understanding of women's reproductive health in relation to chronic disease risk by pooling individual participant data from several cohort and cross-sectional studies. The aim of this paper is to describe the characteristics of contributing studies and to present the distribution of demographic and reproductive factors and chronic disease outcomes in InterLACE

Associations between heartburn and/or regurgitation frequency and adenocarcinomas of the esophagus.

<p>Adjusted for age, sex, BMI, education, alcohol consumption, cigarette smoking, and study-specific variables. Abbreviations: AA, all adenocarcinoma; CI, confidence interval; EA, esophageal adenocarcinoma; EGJA, esophagogastric junction adenocarcinoma; OR.</p

Descriptors of Participants Eligible for Analysis of Heartburn/Regurgitation in Relation to Esophageal Adenocarcinoma and Esophagogastric Junction Adenocarcinoma.

<p>The median and interquartile range of each variable are provided, unless the variable is stated to be a percentage in which case the percentage and 95 percent confidence interval are provided. *This includes PPIs, H2RAs, antacids, and non-specific questions about anti-reflux medications/remedies. Abbreviations: EA, esophageal adenocarcinoma; EGJA, esophagogastric junction adenocarcinoma; FINBAR, Factors Influencing the Barrett’s Adenocarcinoma Relationship (FINBAR) Study. 1Among those exposed.</p

Associations between heartburn & regurgitation frequency, duration and esophageal adenocarcinoma and esophagogastric junction adenocarcinoma.

<p>Adjusted for age, sex, BMI, education, alcohol consumption, cigarette smoking, and study-specific variables. Abbreviations: CI, confidence interval.</p

Forest plots of associations between heartburn and regurgitation exposures in relation to case and control groups in BEACON.

<p>A: The association between recurrent heartburn or recurrent regurgitation in relation to esophageal adenocarcinoma. B: The association between heartburn and regurgitation duration in relation to esophageal adenocarcinoma. C: The association between heartburn and regurgitation frequency in relation to esophageal adenocarcinoma. D. The frequency of recurrent heartburn or recurrent regurgitation exposure in case and control groups by study. For each plot each white square represents the study-specific odds ratio (A–C) or prevalence of exposure (D) and the black diamond represents the overall estimate. The arms of each symbol portray the 95% confidence intervals.</p

Associations between recurrent heartburn and/or recurrent regurgitation and adenocarcinomas of the esophagus.

<p>Adjusted for age, sex, BMI, education, alcohol consumption, cigarette smoking, and study-specific variables. Abbreviations: AA, all adenocarcinoma; CI, confidence interval; EA, esophageal adenocarcinoma; EGJA, esophagogastric junction adenocarcinoma; OR.</p

Associations between heartburn and/or regurgitation duration and adenocarcinomas of the esophagus.

<p>Adjusted for age, sex, BMI, education, alcohol consumption, cigarette smoking, and study-specific variables. Abbreviations: AA, all adenocarcinoma; CI, confidence interval; EA, esophageal adenocarcinoma; EGJA, esophagogastric junction adenocarcinoma; OR.</p