Cefixime and Ofloxacin fixed dose combination induced petechial rash: a case report

Petechial rash is a type of rash which is associated with many infectious and non-infectious conditions. We present a case of Petechial rash induced by administration of cefixime with ofloxacin tablet. A eighteen year old male patient reported to us with a presentation of rash with itching for three days on administration of the fixed dose combination of cefixime + ofloxacin along with paracetamol for the previous symptoms of fever with chills, headache and bodyache. Patient describes itching in the rash which is increasing. The duty doctor attended the patient and immediately stopped the further administration of the offending medication. The patient was prescribed tablet cetirizine orally along with calamine lotion for local application. The patient reported back in for follow-up and was without any residual rashes or other such complaints. He was advised to remember and cautious from the use of drugs in the offending category

Exo-SIR: An Epidemiological Model to Analyze the Impact of Exogenous Spread of Infection

Epidemics like Covid-19 and Ebola have impacted people\u27s lives significantly. The impact of mobility of people across the countries or states in the spread of epidemics has been significant. The spread of disease due to factors local to the population under consideration is termed the endogenous spread. The spread due to external factors like migration, mobility, etc. is called the exogenous spread. In this paper, we introduce the Exo-SIR model, an extension of the popular SIR model and a few variants of the model. The novelty in our model is that it captures both the exogenous and endogenous spread of the virus. First, we present an analytical study. Second, we simulate the Exo-SIR model with and without assuming contact network for the population. Third, we implement the Exo-SIR model on real datasets regarding Covid-19 and Ebola. We found that endogenous infection is influenced by exogenous infection. Furthermore, we found that the Exo-SIR model predicts the peak time better than the SIR model. Hence, the Exo-SIR model would be helpful for governments to plan policy interventions at the time of a pandemic

A Toolbox for Tuberculosis Diagnosis: An Indian Multicentric Study (2006-2008): Microbiological Results

BACKGROUND: The aim of this multicentric prospective study in India was to assess the value of several microbiological tools that contribute to the diagnosis of tuberculosis (TB) according to HIV status. METHODS: Standard microbiological tools on individual specimens were analyzed. RESULTS: Among the 807 patients with active TB, 131 were HIV-infected, 316 HIV-uninfected and 360 had HIV-unknown status. Among the 980 non-active TB subjects, 559 were at low risk and 421 were at high risk of M. tuberculosis (Mtb) exposure. Sensitivity of smear microscopy (SM) was significantly lower in HIV-infected (42.2%) than HIV-uninfected (75.9%) (p = 0.0001) and HIV-unknown pulmonary TB patients (61.4%) (p = 0.004). Specificity was 94.5% in non-TB patients and 100% in health care workers (HCW) and healthy family contacts. Automated liquid culture has significantly higher diagnostic performances than solid culture, measured by sensitivity (74.7% vs. 55.9%) (p = 0.0001) and shorter median time to detection (TTD) (12.0 vs. 34.0 days) (p = 0.0001). Specificity was 100% in HCW and cured-TB patients, but was lower in non-TB patients (89%) due to isolation of Mycobacteria other than tuberculosis (MOTT). TTD by both methods was related to AFB score. Contamination rate was low (1.4%). AccuProbe hybridization technique detected Mtb in almost all culture-positive specimens, but MOTT were found in 4.7% with a significantly higher frequency in HIV-infected (15%) than HIV-uninfected TB patients (0.5%) (p = 0.0007). Pre-test classification significantly increased the diagnostic value of all microbiological tests in pulmonary TB patients (p<0.0001) but to a lesser degree in extrapulmonary TB patients. CONCLUSIONS: Conventional microbiological tools led to results similar to those already described in India special features for HIV-infected TB patients included lower detection by SM and culture. New microbiological assays, such as the automated liquid culture system, showed increased accuracy and speed of detection

Cefixime and Ofloxacin fixed dose combination induced petechial rash: a case report

Petechial rash is a type of rash which is associated with many infectious and non-infectious conditions. We present a case of Petechial rash induced by administration of cefixime with ofloxacin tablet. A eighteen year old male patient reported to us with a presentation of rash with itching for three days on administration of the fixed dose combination of cefixime + ofloxacin along with paracetamol for the previous symptoms of fever with chills, headache and bodyache. Patient describes itching in the rash which is increasing. The duty doctor attended the patient and immediately stopped the further administration of the offending medication. The patient was prescribed tablet cetirizine orally along with calamine lotion for local application. The patient reported back in for follow-up and was without any residual rashes or other such complaints. He was advised to remember and cautious from the use of drugs in the offending category

An Effective Ethnobotanical Medicine Against Hemiplagia

Volume: 98Start Page: 321End Page: 32

Comparison of algorithms for the removal of impulsive noise from an image

Image pre-processing is an important operation that is used to redefine an image to improve human visual perception and information extraction. To de-noise an image tainted with impulsive noise, several state-of-the-art methods have been presented. This work examines and compares several de-noising methods based on the median filter and its advanced non-linear techniques. The research also focuses on the recommended implementation methodologies for using deep learning to de-noise impulsive noise. The paper focuses on one approach's limitations and possible remedies, as well as other techniques that have been offered. The study also identifies several other difficulties that have yet to be resolved

Analysis of the expression of transcription factors and other genes associated with aleurone layer development in wheat endosperm

Defective kernel1 (dek1), crinkly4 (cr4) and supernumerary aleurone layer 1 (sal1) have been suggested as key genes involved in aleurone differentiation in cereals. Transcription factors (TFs) may play a role in regulation of aleurone development by controlling the expression of genes involved in this process. In this study, expression patterns of TFs in developing aleurone and starchy endosperm tissues of wheat was studied using RNA-Seq. Transcript profiles were obtained for aleurone and starchy endosperm tissues of the cultivar Banks at 6, 9 and 14 days post anthesis (DPA). The M-type, MIKC, MYB, CSD and NF-Y TF families were highly up-regulated, in the aleurone while in the starchy endosperm, PLATZ and Dof families were significantly up-regulated. Cr4 and sal1 homologs were identified on chromosomes 7AL, 7BL and 7DL. Dek1 was identified on chromosomes 6AL, 6BL and 6DL. Expression of dek1, cr4, sal1 and risbz1 was higher at the earlier stages of seed development. Further, we observed, sub-genome level partitioning of dek1 expression, with B and D sub-genome dek1 alleles abundantly expressed at all three stages of aleurone development. Expression of sal1 was significantly higher than that of dek1 and cr4. Aleurone development is probably regulated by several epistatic genes in wheat