FEM design and analysis of HAL - Autoclave

Finite Element Structural Analysis of HAL Autoclave System and Components was carried out for the original design under all possible critical load combinations. It was noted that the original design was unsafe from both deformation and stress points of view. Certain design modifications were suggested. Each modification was critically evaluated using simple 1- and 2-dimensional finite element analysis. These modifications were incorporated in the autoclave design and a full-scale finite element analysis was carried out for the modified autoclave system. It was found that the modified system is SAFE from both deformation and stress points of view. MSC-XL is used for finite element modeling and for post-processing the results. MSC/NASTRAN is used for the finite element analysis. FEPACS is used for verification of the MSC/NASTRAN results where necessary

1:4.405 scale LCA High speed air-intake model: Revised analysis and design

As a follow up of the recommendations of the design review committee a few modifications were made in the structural design of the LCA wing. The important among them being the addition of three more bolts on the rear side of the port wing to strengthen, the wing attachments. Steel leading edge proposed in the original design was replaced by an aluminium alloy leading edge. A revised finite element analysis of the wing establishes that in general the stress levels are low over a large portion of the wing. The stress values in the wing bolts show that the bolts have adequate factor of safety. The splitter plate analysis results point to the adequate strength of them, and the natural frequency spectrum, shows that the fundamental frequency of the old model is much above the buzz frequency. The latter observation leads to they conclusion that the buzz noticed in the model is not due to any resonance phenomenon

Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: Synthesis and pharmacological screening

A novel series of pyrazoline amidoxime (2a-d) and pyrazoly-1,2,4-oxadiazole (3a-p) and (4) of pharmacological significance have been synthesised. Structures of newly synthesised compounds were characterized by spectral studies. New compounds were screened for their in vitro antioxidant, antimicrobial and antiinflammatory activities. Among the synthesized compounds, compound 2a, 3l and 3o were found to be active antimicrobial agents in addition to having potent antioxidant activity, while the compound 3f showed promising antiinflammatory activity in comparison with standard drug

Novel pyrazole integrated 1,3,4-oxadiazoles: Synthesis, characterization and antimicrobial evaluation

A novel series of 2-(5-methyl-1,3-diphenyl-1H-pyrazol-4-yl)-5-phenyl-1,3,4- oxadiazoles 7(a-m) were synthesized either by cyclization of N�-benzoyl-5-methyl-1,3-diphenyl-1H-pyrazole-4-carbohydrazide 4a using POCl 3 at 120 C or by oxidative cyclization of hydrazones derived from various arylaldehyde and (E)-N�-benzylidene-5-methyl-1,3-diphenyl-1H- pyrazole-4-carbohydrazide 5(a-d) using chloramine-T as oxidant. Newly synthesized compounds were characterized by analytical and spectral (IR, 1 H NMR, 13 C NMR and LC-MS) methods. The synthesized compounds were evaluated for their antimicrobial activity and were compared with standard drugs. The compounds demonstrated potent to weak antimicrobial activity. Among the synthesized compounds, compound 7m emerged as an effective antimicrobial agent, while compounds 7d, 7f, 7i and 7l showed good to moderate activity. The minimum inhibitory concentration of the compounds was in the range of 20-50 μg mL -1 against bacteria and 25-55 μg mL -1 against fungi. The title compounds represent a novel class of potent antimicrobial agents

One-pot tandem synthesis of tetrasubstituted pyrazoles via 1,3-dipolar cycloaddition between aryl hydrazones and ethyl but-2-ynoate

1,3,4,5-Tetrasubstituted pyrazoles are rapidly and regioselectively synthesized in a one-pot, three-step sequence consisting of condensation, nitrilimine generation, and cycloaddition using mercuric acetate. Newly synthesized compounds were characterized by spectral studies. Regiochemistry of compounds 6a and 8a was determined as 1,4- and 1,5-regioisomers respectively by X-ray crystallography

Structural testing of filament wound fibre reinforced plastic pressure vessels

Pressure vessels fabricated by the filament winding process13; have been the most successful applications of fibre composite materials, The available code of practice like the ASME code for fibre glass reinforced plastic pressure vessels and tanks in reinforced plastics which lay down guidelines for design offer only empirical and semi-empirical methods based primarily on proven safety i n actual service rather than on analytical foundations or optimal considerations,are not adequate for the design of high performance pressure vessels especially using advanced composite material systems. Thus, there is a need to develop and use theoretical methods, by Such methods, obviously using which accurate stress analysis and reliable strength prediction of filament wound fibre reinforced plastic pressure vessels can be carried out. Furthermore, there is also a need for the evaluation of these stress analysis methods by systematic correlation studies with experimental data. In this program,13; attention was therefore focus8ed on the design methods, fabrication procedures and structural testing of filament wound fibre reinforced plastic pressure vessels

A new series of 1,3,4-oxadiazole linked quinolinyl-pyrazole/isoxazole derivatives: synthesis and biological activity evaluation

A series of 1,3,4-oxadiazole bridged pyrazole/isoxazole bearing quinoline derivatives has been designed and synthesized by a clean and convenient method. Structures of the newly synthesized compounds have been confirmed by FTIR, H-1 and C-13 NMR, and HRMS spectral data. The titled compounds have been evaluated for their molecular docking guided antimicrobial and anti-inflammatory activity. One of 1,3,4-oxadiazole bridged quinolinyl-pyrazole derivatives has interacted efficiently with E. Coli protein (PDB file: 1KZN), and has been characterized by good antimicrobial activity against the majority of the tested pathogens. Another product has exhibited excellent anti-inflammatory activity