Environmental quality of marginal territories using comparative analysis of fluctuating asymmetry methods and determining the area of leaf damage

The paper assess marginal and control territories within the Moscow Metropolitan area using a comparative analysis of fluctuating asymmetry method and determining the area of leaf damage to obtain a comprehensive assessment of the territory from the point of view of human habitation with minimal comfort parameters within the sensitivity of plants. The results of the combined analysis of two methods are obtained, which confirm the possibility of their use and the representativeness of the results obtained in assessing the comfort of the environment. The assessment of the quality of the environment in marginal territories was made by quantitative and qualitative indicators for the rational use of land resources, their involvement in economic turnover with the creation of favorable conditions for ensuring the flow of social processes of territorial development and comfortable life support of the population. It was proposed that socially-oriented infrastructure, leisure facilities, and social and cultural facilities have been formed in these territories with a sufficiently large and diverse number of types and forms of employment for the population, which should become the basis for the development of marginal territories

Geometric aspects of certain second order differential systems in particle physics

We consider the problem of the spin 1 particle with anomalous magnetic moment in an external Coulomb field, in non-relativistic approximation. The structural stability of the extended second order ODE system is studied

Characterization of resistance to \u3ci\u3eSynchytrium endobioticum\u3c/i\u3e in cultivated potato accessions from the collection of Vavilov Institute of Plant Industry

The causal agent of potato wart (Synchytrium endobioticum) is an obligate parasitic chytrid fungus. It is included as a quarantine pathogen in 55 countries, with losses in susceptible cultivars reaching 50–100%. The aim of our study was to characterize the resistance to S. endobioticum pathotype 1 in cultivated potatoes from a well characterized subset of the Vavilov Institute of Plant Industry collection and to determine whether this resistance is associated with cultivated potato species taxonomy, with ploidy, with geographic distance or with a molecular marker Nl25-1400 proposed for molecular screening for resistance to pathotype 1 of S. endobioticum. Within the diversity of 52 landrace genotypes, our work shows a lack of such predictive associations with wart resistance. High intraspecific variation of wart diseases resistance allows the selection of extremely resistant and susceptible genotypes available for future genetic and breeding studies

First report of microcephaly-capillary malformations syndrome in Russia

Background: Microcephaly-capillary malformation (MIC-CAP) syndrome is a newly described autosomal recessive syndrome characterized by microcephaly, multiple cutaneous capillary malformations, intractable epilepsy and profound developmental delay. We present the first description of MIC-CAP syndrome in Russia. Patient: We describe a 6-month-old girl with severe congenital microcephaly, intractable epilepsy (infantile spasms), multiple cutaneous capillary malformations and facial abnormalities. Genetic studies revealed the presence of new STAMPB gene mutations in the compound heterozygous state: c.273delA and the intron replacement c.204-5 C > G. Conclusions: This report presents a case of MIC-CAP syndrome with earlier unreported new mutations of the STAMPB gene. Keywords: Microcephaly, Capillary malformations, Epilepsy, Deep developmental delay, STAMBP gen

A First-in-Class β-Glucuronidase Responsive Conjugate for Selective Dual Targeted and Photodynamic Therapy of Bladder Cancer

In this report, we present a novel prodrug strategy that can significantly improve the efficiency and selectivity of combined therapy for bladder cancer. Our approach involved the synthesis of a conjugate based on a chlorin-e6 photosensitizer and a derivative of the tyrosine kinase inhibitor cabozantinib, linked by a β-glucuronidase-responsive linker. Upon activation by β-glucuronidase, which is overproduced in various tumors and localized in lysosomes, this conjugate released both therapeutic modules within targeted cells. This activation was accompanied by the recovery of its fluorescence and the generation of reactive oxygen species. Investigation of photodynamic and dark toxicity in vitro revealed that the novel conjugate had an excellent safety profile and was able to inhibit tumor cells proliferation at submicromolar concentrations. Additionally, combined therapy effects were also observed in 3D models of tumor growth, demonstrating synergistic suppression through the activation of both photodynamic and targeted therapy

Altered brain dynamic in major depressive disorder: state and trait features

Abstract Temporal neural synchrony disruption can be linked to a variety of symptoms of major depressive disorder (MDD), including mood rigidity and the inability to break the cycle of negative emotion or attention biases. This might imply that altered dynamic neural synchrony may play a role in the persistence and exacerbation of MDD symptoms. Our study aimed to investigate the changes in whole-brain dynamic patterns of the brain functional connectivity and activity related to depression using the hidden Markov model (HMM) on resting-state functional magnetic resonance imaging (rs-fMRI) data. We compared the patterns of brain functional dynamics in a large sample of 314 patients with MDD (65.9% female; age (mean ± standard deviation): 35.9 ± 13.4) and 498 healthy controls (59.4% female; age: 34.0 ± 12.8). The HMM model was used to explain variations in rs-fMRI functional connectivity and averaged functional activity across the whole-brain by using a set of six unique recurring states. This study compared the proportion of time spent in each state and the average duration of visits to each state to assess stability between different groups. Compared to healthy controls, patients with MDD showed significantly higher proportional time spent and temporal stability in a state characterized by weak functional connectivity within and between all brain networks and relatively strong averaged functional activity of regions located in the somatosensory motor (SMN), salience (SN), and dorsal attention (DAN) networks. Both proportional time spent and temporal stability of this brain state was significantly associated with depression severity. Healthy controls, in contrast to the MDD group, showed proportional time spent and temporal stability in a state with relatively strong functional connectivity within and between all brain networks but weak averaged functional activity across the whole brain. These findings suggest that disrupted brain functional synchrony across time is present in MDD and associated with current depression severity