15 research outputs found
Executive Functions and Cognitive Deficits in Schizophrenia: Comparisons Between Probands, Parents and Controls in India
Background: Cognitive impairment is said to be a core feature of
schizophrenia. Executive function is an important cognitive domain.
Aim: This study was undertaken to assess cognitive impairment among
Indian patients with schizophrenia (Sz) or schizoaffective disorder
(SzA), compared with their parents and unaffected individuals
(controls). Settings and Design: Executive functions as measured by
Trail-making Test (TMT), of patients and their parents were compared
with controls. The patients were recruited from the Outpatients′
Department (OPD) of a government hospital. Materials and Methods:
Patients diagnosed as Sz or SzA (n=172) and their parents (n=196:
families n=132, 119 fathers and 77 mothers) participated. We also
included 120 persons with no history of psychiatric illness. Cognitive
function was assessed with the TMT. The Information Score of the Post
Graduate Institute Battery of Brain Dysfunction test, developed in
India for Indian subjects was used as a proxy for general fixed
knowledge. Statistical Analysis: Logistic and linear regression was
used to compare cognitive deficits of cases, parents and controls.
Results: Cases and their parents took significantly more time than
controls on Part B of the TMT. There were no statistically significant
differences between cases and parents on any of the TMT parameters.
Using regression analysis, the most significant correlates of all TMT
parameters among cases were with occurrence of auditory hallucinations
and current age. Conclusion: Cases, as well as their parents showed
more cognitive impairment than controls on the TMT
Further evidence for an association between schizophrenia and the HLA DQB1 gene locus
10.1016/0920-9964(95)00023-2Schizophrenia Research18143-49SCRS
Immune related genetic polymorphisms and schizophrenia among the Chinese
10.1016/S0198-8859(01)00256-7Human Immunology627714-724HUIM