BRAF V600E mutation in papillary thyroid cancer is correlated with adverse clinicopathological features but not with iodine exposure

Introduction: BRAFV600E activating mutation is the most frequent genetic abnormality in the pathogenesis of papillary thyroid carcinoma. We aimed to evaluate the association between BRAFV600E mutation and well-established prognostic clinicopathological characteristics as well as iodine exposure. Material and methods: From 2000 to 2012, the data of PTC patients admitted to Dr. Lutfi Kirdar Kartal Education and Research Hospital in Turkey were reviewed retrospectively. Clinicopathological parameters were collected. BRAFV600E mutation was analysed by DNA sequencing method in tumour specimens. We hypothesised that BRAFV600E mutation prevalence is positively correlated with prolonged iodine exposure and expected to be higher in the second half of the recruitment period due to the increment in time spent from the iodisation process of the table salt in our country. Thus, iodine exposure was categorised as short-term (2000–2006) and long-term (2006–2012). Results: A total of 197 patients were accrued. The study population predominantly consisted of conventional variant. A statistically significant relationship was observed between BRAFV600E mutation presence and age (p = 0.03), conventional variant PTC (p = 0.00002), T4 stage (p = 0.002), vascular invasion (p = 0.036), thyroid capsule invasion (p < 0.00001), extrathyroidal tissue invasion (p < 0.00001), and lymph node metastasis (p < 0.00001). When categorised as long-term and short-term, iodine exposure was not statistically significantly related with BRAFV600E mutation; however, there were far more PTC cases in the long-term group (86.3% vs. 13.7%). Conclusion: We revealed that BRAFV600E mutation is associated with adverse clinicopathological parameters. There appeared to be no relation between long-term iodine exposure and BRAFV600E.

Calcifying aponeurotic fibroma: A case report

Kalsifiye aponörotik fibrom nadir rastlanan, histopatolojik özellikleri iyi tanımlanmış, benign fibröz bir tümördür. Genellikle çocuk ve gençlerde distal ekstremitelerde görülür. Yirmi üç yaşında erkek hastada sol el palmar yüzde yaklaşık beş yıldır var olan ağrısız serbest yumuşak doku kitlesi cerrahi olarak çıkarıldı. Histopatolojik incelemede kalsifikasyon ve kondroid metaplazi alanlarını çevreleyen fibroblastik proliferasyon alanları ve yoğun kollajenöz stroma izlendi. Lezyona kalsifiye aponörotik fibrom tanısı kondu. Hastanın bir yıllık izleminde nüks görülmedi.Calcified aponeurotic fibroma is a rare benign fibrous tumor with well-characterized histopathologic features. It is usually seen in distal extremities of children and youngsters. A 23-year-old male patient underwent surgical excision of a free, painless soft tissue mass that developed in the palmar aspect of the left hand. Histopathologic examination showed fibroblastic proliferation areas and dense collagenous stroma surrounding calcifications and chondroid metaplasia. The diagnosis was made as calcified aponeurotic fibroma. No recurrences were detected within a year follow-up

Heterotopic thyroid tissue presenting as a porta hepatis mass

WOS: 00024945460075

Glioblastoma multiforme with extensive neuronal differentiation: Case report

WOS: 00025619260037

Sarcomatoid carcinoma of the renal pelvis and ureter: A case report with immunohistochemical findings

WOS: 00025619260063

Postpartum Tanı Alan Metastatik Renal Hücreli Karsinom Olgusu.

A Case of Metastatic Renal Cell Carsinoma Diagnosed in Postpartum Period10.5222/otd.2013.113Funda ÇınkılMehmet AliustaoğluKemal EkiciSeydahmet AkınAlpaslan MayadağlıErcan ErginNimet KaradayıReceived Date: 06.01.2013Accepted Date: 25.04.2013Eur Arc Med Res 2013;29(2):113-116Abstract&nbsp;1&nbsp;231Renal cell carcinoma (RCC) is most frequently seen between the ages of 50-70, but occasionally diagnosed during pregnancy. RCC is the most commonly encountered renal neoplasm in pregnancy. Most cases are incidentally diagnosed in pregnancy. Sometimes diagnosis delays because of concomitant urinary semptoms which occurs frequently in gestation. The probability of cure and management of the disease is directly related to the stage and degree of tumor dissemination. We discussed a 35 years old postpartum metastatic RCC case.Keywords:&nbsp;&nbsp;postpartum period, pregnancy, renal cell carcinoma</div

Role of 18F FDG PETCT in marginal zone lymphomas

Annual Congress of the European-Association-of-Nuclear-Medicine -- OCT 15-19, 2016 -- Barcelona, SPAINWOS: 000391802400189…European Association of Nuclear Medicin

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Inducible nitric oxide synthase expression in gastric adenocarcinoma: impact o