Transient hearing loss in adults associated with Zika virus infection

In 2015, during the outbreak of Zika virus (ZIKV) in Brazil, we identified 3 cases of acute hearing loss after exanthematous illness. Serology yielded finding compatible with ZIKV as the cause of a confirmed (n = 1) and a probable (n = 2) flavivirus infection, indicating an association between ZIKV infection and transient hearing loss.status: publishe

Transient hearing loss in adults associated with Zika virus infection

This work was supported by the National Institutes of Health (grant numbers 1 R01 AI121207 and R24 AI120942). R. K. and L. A. S. were supported by “Programa Ciências sem fronteiras,” Conselho Nacional de Desenvolvimento Cientifico e Tecnológico of Brazil.Hospital Santa Izabel. Salvador, BA, Brazil.Ministério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brazil.Hospital Santa Izabel. Salvador, BA, Brazil.Hospital Santa Izabel. Salvador, BA, Brazil.Hospital Santa Izabel. Salvador, BA, Brazil.Hospital Santa Izabel. Salvador, BA, Brazil.Ministério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. World Health Organization Collaborating Center for Reference and Research on Arbovirus. Ananindeua, PA, Brasil.University of Texas Medical Branch. Center for Biodefense and Emerging Infectious Diseases. Department of Pathology. Galveston, TX, USA.University of Texas Medical Branch. Center for Biodefense and Emerging Infectious Diseases. Department of Pathology. Galveston, TX, USA.Ministério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brazil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA.Ministério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brazil / José Silveira Foundation. Research Initiative. Multinational Organization Network Sponsoring Translational and Epidemiological. Salvador, BA, BrazilMinistério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brazil.Ministério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brazil / KU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium.Hospital Santa Izabel. Salvador, BA, Brazil / Ministério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brazil.In 2015, during the outbreak of Zika virus (ZIKV) in Brazil, we identified 3 cases of acute hearing loss after exanthematous illness. Serology yielded finding compatible with ZIKV as the cause of a confirmed (n = 1) and a probable (n = 2) flavivirus infection, indicating an association between ZIKV infection and transient hearing loss

Transient Hearing Loss in Adults Associated with Zika Virus Infection

This work was supported by the National Institutes of Health (grant numbers 1 R01 AI121207 and R24 AI120942). R. K. and L. A. S. were supported by “Programa Ciências sem fronteiras,” Conselho Nacional de Desenvolvimento Cientifico e Tecnológico of Brazil.Hospital Santa Izabel. Salvador, BA, Brazil.Ministério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brazil.Hospital Santa Izabel. Salvador, BA, Brazil.Hospital Santa Izabel. Salvador, BA, Brazil.Hospital Santa Izabel. Salvador, BA, Brazil.Hospital Santa Izabel. Salvador, BA, Brazil.Ministério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. World Health Organization Collaborating Center for Reference and Research on Arbovirus. Ananindeua, PA, Brasil.University of Texas Medical Branch. Center for Biodefense and Emerging Infectious Diseases. Department of Pathology. Galveston, TX, USA.University of Texas Medical Branch. Center for Biodefense and Emerging Infectious Diseases. Department of Pathology. Galveston, TX, USA.Ministério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brazil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA.Ministério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brazil / José Silveira Foundation. Research Initiative. Multinational Organization Network Sponsoring Translational and Epidemiological. Salvador, BA, BrazilMinistério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brazil.Ministério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brazil / KU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium.Hospital Santa Izabel. Salvador, BA, Brazil / Ministério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brazil.In 2015, during the outbreak of Zika virus (ZIKV) in Brazil, we identified 3 cases of acute hearing loss after exanthematous illness. Serology yielded finding compatible with ZIKV as the cause of a confirmed (n = 1) and a probable (n = 2) flavivirus infection, indicating an association between ZIKV infection and transient hearing loss

Tratamento cirúrgico de nasoangiofibroma sem embolização Surgical Treatment of Non-embolized Patients with Nasoangiofibroma

Nasoangiofibroma juvenil (NAFJ) é um tumor incomum que se localiza na região do forame esfenopalatino. A cirurgia combinada à embolização pré-operatória tem sido a opção terapêutica mais empregada nos pacientes com NAFJ sem invasão intracraniana. O objetivo desse estudo é avaliar a viabilidade do tratamento cirúrgico do nasoangiofibroma em pacientes estágios I- III de Fisch, sem uso de embolização pré- operatória. MATERIAL E MÉTODO: Estudo descritivo, retrospectivo, utilizando-se dados de revisão de prontuário de quinze pacientes com NAFJ estágio I a III de Fisch submetidos à cirurgia sem embolização pré-operatória, entre os anos de 2000 e 2005. RESULTADOS: Dos quinze pacientes, sete pacientes foram submetidos à cirurgia endoscópica, quatro via transmaxilar, três via endoscópica e transmaxilar e um via transmaxilar e transpalatina. Seis pacientes necessitaram de hemotransfusão no intra-operatório, com média geral de 1.3 bolsa/paciente. Nenhum caso de mortalidade ou morbidade significativa foi registrado. Onze dos quinze pacientes foram acompanhados por tempo médio de doze meses com taxa de recidiva de 27%. Quatro pacientes perderam seguimento. CONLUSÃO: A ressecção de NAFJ classes I- III foi realizada com segurança em pacientes não-embolizados, com taxa de sangramento intraoperatório, ocorrência de complicações e taxa de recorrência próximas dos valores pesquisados na literatura para pacientes embolizados.<br>Juvenile nasopharyngeal angiofibroma (JNA) is an uncommon tumor of the sphenopalatine foramen. Surgery combined with preoperative embolization has been the treatment of choice for JNA patients without intracranial invasion. This study aims to assess the viability of surgically treating non-embolized patients with JNA (types I-III according to Fisch). MATERIAL AND METHOD: This is a retrospective, descriptive study based on the medical records of 15 patients with histologically confirmed JNA (Fisch’s types I- III), who underwent surgical treatment without pre-op embolization in our institution between 2000 and 2005. RESULTS: Seven of the fifteen patients were approached endoscopically, four through the transantral approach, three were treated with the combined transmaxillary and endoscopic approach, and one with the combined transmaxillary and transpalatal approach. Six patients required intraoperatory blood transfusion, averaging volumes of 1.3 unit/patient. There were no cases of death or significant morbidity. Eleven of the fifteen patients were followed for an average of twelve months and 27% of them relapsed. Four patients did not comply with the follow-up scheme. CONCLUSION: Resection of JNF types I-III was safely completed in non-embolized patients. The observed levels of intraoperative bleeding, occurrence of complications, and rates of recurrence were close to those seen in embolized patients as found in the literature