Evaluation of the Apolipoprotein B R3500Q Gene Mutation in Nonvalvular Atrial Fibrillation with Ischemic Stroke in Turkish Population

29th Turkish Cardiology Congress of the Turkish-Society-of-Cardiology (TSC) with International Participation -- OCT 26-29, 2013 -- Antalya, TURKEYWOS: 000329858400355…Turkish Soc Cardio

The Usage of new generation antiepileptic drugs during the pregnancy

Epilepsi toplumda sık görülen bir hastalıktır. Hem anne hem de bebeğin hayatını ilgilendiren gebelik sürecinde, epilepsi gibi kronik bir hastalığın takibi ayrı bir önem taşımaktadır. Bu yazıda; gebelikte epilepsi hastalığının seyri, tedavide yeni nesil antiepileptik ilaçların kullanımı, bu ilaçların fetus üzerine etkileri ve farmakokinetiklerindeki değişikliklere değinilmiştir.Epilepsy is a common disease in the community. Chronic illness, such as epilepsy that has been concerning the lives of both mother and baby during pregnancy, following-up is getting more important. In this paper, the course of epilepsy during pregnancy, usage of new- generation antiepileptic drugs for treatment of epilepsy, the effects of these drugs on the fetus and changes of pharmacokinetic are mentioned

Prevalence Of Thrombophilic Mutations In Ischemic Stroke Patients In Isparta, Turkey

OBJECTIVE: The present study aimed to investigate whether the frequency of factor V, methylenetetrahydrofolate reductase (MTHFR), prothrombin, β-fibrinogen gene mutations, and human platelet alloantigens (HPA), plasminogen activator inhibitor 1 (PAI1), apolipoprotein E (APOE), and angiotensin converting enzyme (ACE) gene polymorphisms in stroke patients is higher than that in normal individuals. METHODS: Two hundred twelve patients with cerebral infarction and 238 individuals of similar age and gender with no history of stroke were included. Demographics and risk factors for cerebrovascular disease of all individuals were determined. Biochemical parameters were analyzed in serum, and electrocardiography was performed. Factor V, MTHFR, prothrombin, β-fibrinogen mutations and HPA, PAI, APOE, and ACE polymorphisms were investigated. Data were analyzed with SPSS 15.0 software using descriptive statistics, chi-square, independent two-group t-test, and logistic regression tests. Statistically significant differences in independent variables were further analyzed by logistic regression. p < 0.05 was considered statistically significant. RESULTS: HPA, PAI, APO, and ACE polymorphism frequency was not significantly different between the stroke and control groups. Factor V H1299R, factor V Leiden, and β fibrinogen -455GA mutation frequency was significantly higher in the stroke than the control group by the chi-square test, but not by logistic regression analysis. CONCLUSION: Stroke etiopathogenesis is multifactorial, and prothrombin gene mutations increase the impact of existing risk factors when other risk factors are considered

Prevalence of Thrombophilic Mutations in Ischemic Stroke Patients in Isparta, Turkey

Objective: The present study aimed to investigate whether the frequency of factor V, methylenetetrahydrofolate reductase (MTHFR), prothrombin, beta-fibrinogen gene mutations, and human platelet alloantigens (HPA), plasminogen activator inhibitor 1 (PAI1), apolipoprotein E (APOE), and angiotensin converting enzyme (ACE) gene polymorphisms in stroke patients is higher than that in normal individuals

Kanserli Yaşlıda Anoreksi-Kaşeksi Sendromu ve Tedavisi

Weight loss occurs in 30-80% of cancer patients. Weight loss depends on the cancer type, the effected organ-tissue, size and cell turnover. Weight loss is more aggressive in gastric and pancreatic cancers. Patients frequently admit in higher stages of the diasease with severe weight loss. Lung, prostate and colon cancer follow them according to prevalance of cachexia. Proteolysis inducing factor and inflammatory cytokines cause proteolysis and increased energy expenditure due to hypercathabolic situation. Ghrelin receptor resistance causes anorexia. Localization of the tumour, surrounding tissue damage and adverse effects of the treatment procedures can also cause anorexia and weight loss. Weight loss, especially decreased lean body mass, influences the success of the treatment, increases the morbidity and mortality. A significant number of the patients die because of malnutrition and associated adverse events like infection, instead of the diasease itself. Then, early nutrition assessment after the diagnosis is essential with regular visits during the follow-up. When diagnosed, malnutrition or malnutrition risk must be treated immediatel

Differences in lymphocyte subpopulation count and function in cord, maternal and adult blood

Objective: Phenotypical characterization and functional activity of lymphocytes and natural killer (NK) cells in cord blood (CB) were investigated, and maternal peripheral blood (MPB) values were compared to those of adult peripheral blood (APB) (control)