High power ultra-short pulse Quantum-dot lasers

In this thesis, novel multi-section laser diodes based on quantum-dot material are designed and investigated which exhibit a number of advantages such as low threshold current density; temperature-insensitivity and suppress carrier diffusion due to discrete nature of density of state of quantum-dots. The spectral versatility in the range of 1.1 µm – 1.3 µm wavelengths is demonstrated through novel mode-locking regimes such as dual-wavelength mode-locking, wavelength bistability and broad tunability. Moreover, broad pulse repetition rate tuning using an external cavity configuration is presented. A high peak power of 17.7 W was generated from the quantum-dot laser as a result of the tapered geometry of the gain section of the laser has led to successful application of such device for two-photon imaging. Dual-wavelength mode-locking is demonstrated via ground (?=1180 nm) and excited (?=1263 nm) spectral bands with optical pulses from both states simultaneously in the 5-layer quantum-dot two-section diode laser. The widest spectral separation of 83 nm between the modes was achieved in a dual-wavelength mode-locked non-vibronic laser. Power and wavelength bistability are achieved in a mode-locked multi-section laser which active region incorporates non-identical QD layers grown by molecular beam epitaxy. As a result the wavelength can be electronically controlled between 1245 nm and 1290 nm by applying different voltages to the saturable absorber. Mode-locked or continuous-wave regimes are observed for both wavelengths over a 260 mA – 330 mA current ranges with average power up to 28 mW and 31 mW, respectively. In mode-locked regime, a repetition rate of 10 GHz of optical pulses as short as 4 ps is observed. Noticeable hysteresis of average power for different bias conditions is also demonstrated. The wavelength and power bistability in QD lasers are potentially suitable for flip-flop memory application. In addition, a unique mode-locked regime at expense of the reverse bias with 50 nm wavelength tuning range from 1245 nm to 1290 nm is also presented. Broad repetition rate tunability is shown from quantum-dot external cavity mode-locked 1.27 µm laser. The repetition rate from record low of 191 MHz to 1 GHz from fundamental mode-locking was achieved. Harmonic mode-locking allows further to increase tuning up to 6.8 GHz (34th-order harmonic) from 200 MHz fundamental mode-locking. High peak power of 1.5 W can be generated directly from two-section 4 mm long laser with bent waveguide at angle of 7° at 1.14 GHz repetition rate without the use of any pulse compression and optical amplifier. Stable mode-locking with an average power up to 60 mW, corresponding to 25 pJ pulse energy is also obtained at a repetition frequency of 2.4 GHz. The minimum time-bandwidth product of 1.01 is obtained with the pulse duration of 8.4 ps. Novel tapered quantum-dot lasers with a gain-guided geometry operating in a passively mode-locked regime have been investigated, using structures that incorporated either 5 or 10 quantum dot layers. The peak power of 3.6 W is achieved with pulse duration of 3.2 ps. Furthermore, the record peak power of 17.7 W and transform limited pulses of 672 fs were achieved with optimized structure. The generation of picosecond pulses with high average power of up to 209 mW was demonstrated, corresponding to 14.2 pJ pulse energy. The improved optical parameters of the tapered laser enable to achieve nonlinear images of fluorescent beads. Thus it is for the first time that QD based compact monolithic device enables to image biological samples using two-photon microscopy imaging technique.EThOS - Electronic Theses Online ServiceEU FP7 “FAST-DOT” project (Grant No. 224338)GBUnited Kingdo

Generation of tunable visible picosecond pulses by frequency-doubling of a quantum-dot laser in a PPKTP waveguide

We demonstrate a compact all-room-temperature picosecond laser source broadly tunable in the visible spectral region between 600 nm and 627 nm. The tunable radiation is obtained by frequency-doubling of a tunable quantum-dot external-cavity mode-locked laser in a periodically-poled KTP multimode waveguide. In this case, utilization of a significant difference in the effective refractive indices of the high- and low-order modes enables to match the period of poling in a very broad wavelength range. The maximum achieved second harmonic output peak power is 3.25 mW at 613 nm for 71.43 mW of launched pump peak power at 1226 nm, resulting in conversion efficiency of 4.55%

Patient-Specific 3D Printed Models for Education, Research and Surgical Simulation

3D printing techniques are increasingly used in engineering science, allowing the use of computer aided design (CAD) to rapidly and inexpensively create prototypes and components. There is also growing interest in the application of these techniques in a clinical context for the creation of anatomically accurate 3D printed models from medical images for therapy planning, research, training and teaching applications. However, the techniques and tools available to create 3D models of anatomical structures typically require specialist knowledge in image processing and mesh manipulation to achieve. In this book chapter we describe the advantages of 3D printing for patient education, healthcare professional education, interventional planning and implant development. We also describe how to use medical image data to segment volumes of interest, refine and prepare for 3D printing. We will use a lung as an example. The information in this section will allow anyone to create own 3D printed models from medical image data. This knowledge will be of use to anyone with little or no previous experience in medical image processing who have identified a potential application for 3D printing in a medical context, or those with a more general interest in the techniques

Anatomically realistic ultrasound phantoms using gel wax with 3D printed moulds

Here we describe methods for creating tissue-mimicking ultrasound phantoms based on patient anatomy using a soft material called gel wax. To recreate acoustically realistic tissue properties, two additives to gel wax were considered: paraffin wax to increase acoustic attenuation, and solid glass spheres to increase backscattering. The frequency dependence of ultrasound attenuation was well described with a power law over the measured range of 3 to 10 MHz. With the addition of paraffin wax in concentrations of 0 to 8 w/w%, attenuation varied from 0.72 to 2.91 dB/cm at 3 MHz and from 6.84 to 26.63 dB/cm at 10 MHz. With solid glass sphere concentrations in the range of 0.025 to 0.9 w/w%, acoustic backscattering consistent with a wide range of ultrasonic appearances was achieved. Native gel wax maintained its integrity during compressive deformations up to 60%; its Young's modulus was 17.4 ± 1.4 kPa. The gel wax with additives was shaped by melting and pouring it into 3D printed moulds. Three different phantoms were constructed: a nerve and vessel phantom for peripheral nerve blocks, a heart atrium phantom, and a placental phantom for minimally-invasive fetal interventions. In the first, nerves and vessels were represented as hyperechoic and hypoechoic tubular structures, respectively, in a homogeneous background. The second phantom comprised atria derived from an MRI scan of a patient with an intervening septum and adjoining vena cavae. The third comprised the chorionic surface of a placenta with superficial fetal vessels derived from an image of a post-partum human placenta. Gel wax is a material with widely tuneable ultrasound properties and mechanical characteristics that are well suited for creating patient-specific ultrasound phantoms in several clinical disciplines

High-Power Versatile Picosecond Pulse Generation from Mode-Locked Quantum-Dot Laser Diodes

This paper presents the current status of our research in mode-locked quantum-dot edge-emitting laser diodes, particularly highlighting the recent progress in spectral and temporal versatility of both monolithic and external-cavity laser configurations. Spectral versatility is demonstrated through broadband tunability and novel mode-locking regimes that involve distinct spectral bands, such as dual-wavelength mode-locking, and robust high-power wavelength bistability. Broad tunability of the pulse repetition rate is also demonstrated for an external-cavity mode-locked quantum-dot laser, revealing a nearly constant pulse peak power at different pulse repetition rates. High-energy and low-noise pulse generations are demonstrated for low-pulse repetition rates. These recent advances confirm the potential of quantum-dot lasers as versatile, compact, and low-cost sources of ultrashort pulses

Medical-grade Sterilizable Target for Fluid-immersed Fetoscope Optical Distortion Calibration

We have developed a calibration target for use with fluid-immersed endoscopes within the context of the GIFT-Surg (Guided Instrumentation for Fetal Therapy and Surgery) project. One of the aims of this project is to engineer novel, real-time image processing methods for intra-operative use in the treatment of congenital birth defects, such as spina bifida and the twin-to-twin transfusion syndrome. The developed target allows for the sterility-preserving optical distortion calibration of endoscopes within a few minutes. Good optical distortion calibration and compensation are important for mitigating undesirable effects like radial distortions, which not only hamper accurate imaging using existing endoscopic technology during fetal surgery, but also make acquired images less suitable for potentially very useful image computing applications, like real-time mosaicing. In this paper proposes a novel fabrication method to create an affordable, sterilizable calibration target suitable for use in a clinical setup. This method involves etching a calibration pattern by laser cutting a sandblasted stainless steel sheet. This target was validated using the camera calibration module provided by OpenCV, a state-of-the-art software library popular in the computer vision community.status: publishe

Medical-grade sterilizable target for fluid-immersed fetoscope optical distortion calibration

We have developed a calibration target for use with fluid-immersed endoscopes within the context of the GIFT-Surg (Guided Instrumentation for Fetal Therapy and Surgery) project. One of the aims of this project is to engineer novel, real-time image processing methods for intra-operative use in the treatment of congenital birth defects, such as spina bifida and the twin-to-twin transfusion syndrome. The developed target allows for the sterility-preserving optical distortion calibration of endoscopes within a few minutes. Good optical distortion calibration and compensation are important for mitigating undesirable effects like radial distortions, which not only hamper accurate imaging using existing endoscopic technology during fetal surgery, but also make acquired images less suitable for potentially very useful image computing applications, like real-time mosaicing. In this paper proposes a novel fabrication method to create an affordable, sterilizable calibration target suitable for use in a clinical setup. This method involves etching a calibration pattern by laser cutting a sandblasted stainless steel sheet. This target was validated using the camera calibration module provided by OpenCV, a state-of-the-art software library popular in the computer vision community

Interventional multispectral photoacoustic imaging with a clinical linear array ultrasound probe for guiding nerve blocks

Accurate identification of tissue structures such as nerves and blood vessels is critically important for interventional procedures such as nerve blocks. Ultrasound imaging is widely used as a guidance modality to visualize anatomical structures in real-time. However, identification of nerves and small blood vessels can be very challenging, and accidental intra-neural or intra-vascular injections can result in significant complications. Multi-spectral photoacoustic imaging can provide high sensitivity and specificity for discriminating hemoglobin-and lipid-rich tissues. However, conventional surface-illumination-based photoacoustic systems suffer from limited sensitivity at large depths. In this study, for the first time, an interventional multispectral photoacoustic imaging (IMPA) system was used to image nerves in a swine model in vivo. Pulsed excitation light with wavelengths in the ranges of 750-900 nm and 1150-1300 nm was delivered inside the body through an optical fiber positioned within the cannula of an injection needle. Ultrasound waves were received at the tissue surface using a clinical linear array imaging probe. Co-registered B-mode ultrasound images were acquired using the same imaging probe. Nerve identification was performed using a combination of B-mode ultrasound imaging and electrical stimulation. Using a linear model, spectral-unmixing of the photoacoustic data was performed to provide image contrast for oxygenated and de-oxygenated hemoglobin, water and lipids. Good correspondence between a known nerve location and a lipid-rich region in the photoacoustic images was observed. The results indicate that IMPA is a promising modality for guiding nerve blocks and other interventional procedures. Challenges involved with clinical translation are discussed

From medical imaging data to 3D printed anatomical models.

Anatomical models are important training and teaching tools in the clinical environment and are routinely used in medical imaging research. Advances in segmentation algorithms and increased availability of three-dimensional (3D) printers have made it possible to create cost-efficient patient-specific models without expert knowledge. We introduce a general workflow that can be used to convert volumetric medical imaging data (as generated by Computer Tomography (CT)) to 3D printed physical models. This process is broken up into three steps: image segmentation, mesh refinement and 3D printing. To lower the barrier to entry and provide the best options when aiming to 3D print an anatomical model from medical images, we provide an overview of relevant free and open-source image segmentation tools as well as 3D printing technologies. We demonstrate the utility of this streamlined workflow by creating models of ribs, liver, and lung using a Fused Deposition Modelling 3D printer