A 2:1 Co-Crystal of Hydroquinone and 3,5-Bis(2-pyridyl)-1,2,4-triazole

The title compound, 2C₁₂H₉N5₅.C₆H₆O₂, exhibits a three-dimensional hydrogen-bonded network of N-H...N, C-H...N, O-H...N, C-H...O, C-H...π and π...π interactions

Cytoreductive Surgery with the PlasmaJet Improved Quality-of-Life for Advanced Stage Ovarian Cancer Patients

Background: Knowledge of quality-of-life after cytoreductive surgery is important to counsel patients with advanced-stage epithelial ovarian cancer prior to surgery. The aim of this study was to determine whether the use of the PlasmaJet Surgical device during cytoreductive surgery has an effect on the quality-of-life of patients with advanced epithelial ovarian cancer. Methods: Data included in this prospective observational study were derived from the PlaComOv study, in which patients with advanced epithelial ovarian cancer were randomly assigned to have cytoreductive surgery with or without adjuvant use of the PlasmaJet. Quality-of-life was measured before surgery and one, six, 12, and 24 months after surgery with three questionnaires: the EORTC QLQ-C30, QLQ-OV28, and EQ-5D-5L. Results: Between 2018 and 2020, 326 patients were enrolled in the trial. The overall response rate was high, with the lowest response rate at 24 months of 77%. At 6 months, quality-of-life was higher in the intervention group (95%CI 0.009; 0.081, p = 0.045). At 12 months, quality-of-life was higher in the intervention group with fewer symptoms of fatigue, appetite loss, and diarrhea (95%CI 0.6; 10,0, p = 0.027); similarly, patients in the intervention group reported a better body image (95%CI −14.2; −3.0, p = 0.003) and a higher score on the visual analog scale (95%CI 1.99; 11.15, p = 0.005). At 24 months postoperatively, no further difference was found between the two groups except for pain (95%CI −12.9; −0.8, p = 0.027) and body image (95%CI −13.808; −0.733, p = 0.029). A higher quality-of-life in the intervention group was partially explained by the mediator ‘surgery outcome’. Conclusions: This study demonstrated knowledge of patients’ quality-of-life until two years after cytoreductive surgery. The use of the PlasmaJet Surgical device during cytoreductive surgery leads to a higher quality-of-life than conventional surgery with electrocoagulation alone. Even after adjustment for the mediator of surgical outcome, a higher quality-of-life was seen in patients who had surgery with the use of the PlasmaJet device.</p

INFORMATIEBEHOEFTEN VAN BRANCHEGENOTEN

INFORMATIEBEHOEFTEN VAN BRANCHEGENOTE

KORT OVERZICHT VAN HET ECONOMISCH ONDERZOEK IN DE LANDBOUW, TUINBOUW EN VISSERIJ

KORT OVERZICHT VAN HET ECONOMISCH ONDERZOEK IN DE LANDBOUW, TUINBOUW EN VISSERI

Relaxation processes in room temperature ionic liquids: The case of 1-methyl-3-butyl imidazolium hexafluorophosphate

A detailed investigation on the nature of the relaxation processes occurring in a typical room temperature ionic liquid (RTIL), namely, 1-butyl-3-methyl imidazolium hexafluorophosphate ([bmim][PF(6)]), is reported. The study was conducted using both elastic and inelastic neutron scattering over a wide temperature range from 10 to 400 K, accessing the dynamic features of both the liquid and glassy amorphous states. In this study, the inelastic fixed energy scan technique has been applied for the first time to this class of materials. Using this technique, the existence of two relaxation processes below the glass transition and a further diffusive process occurring above the glass-liquid transition are observed. The low temperature processes are associated with methyl group rotation and butyl chain relaxation in the glassy state and have been modeled in terms of two Debye-like, Arrhenius activated processes. The high temperature process has been modeled in terms of a Kohlraush-Williams-Watts relaxation, with a distinct Vogel-Fulcher-Tamman temperature dependence. These results provide novel information that will be useful in rationalizing the observed structural and dynamical behavior of RTILs in the amorphous state

Novel ionic media for liquid lasers

In a search for 3-5 µm lasing materials, crystals Of AlBr6Sb are isolated from a phosphorus tribromide-aluminium tribromide-antimony tribromide (PBr3-AlBr3-SbBr3) solution: this solid contains infinite chains of alternating [SbBr2]+ cations and [AlBr4]+ anions, linked by weak coordinate bonds, and represents the first structure containing the dibromostibinium(III) cation

Crystal structure of (η⁵ pentamethylcyclopentadienyl){bis(pentafluorophenyl)×thiomethylphenyl phosphine-κ₂ S,P)chloro-iridium(III) tetrafluoroborate

The salt (η⁵-pentamethylcyclopentadienyl){bis(pentafluorophenyl)thiomethylphenylphosphine-κ₂ S,P)chloroiridium(III) tetrafluoroborate, [(η⁵-C₅Me₅)IrCl{κ₂ S,P-(C₆F₅)₂PC₆H₄SMe-2}]BF₄, crystallizes as a conglomerate in the orthorhombic crystal system in space group P2₁2₁2₁ with unit cell parameters a = 9.9621(9) Å, b = 16.7793(15) Å, c = 18.5040(16) Å, V = 3093.1(5) ų, Z = 4, d calc = 2.014 g•cm⁻³. The structure of the S Ir, S S stereoisomer reveals three-legged piano stool geometry about Ir, with Cp*-Ir, Ir-P, Ir-S and Ir-Cl distances of 1.847(5) Å, 2.2791(14) Å, 2.3451(13) Å, and 2.3840(12) Å respectively