1,094 research outputs found
Antiviral Effector RTP4 Bats against Flaviviruses
Bats harbor diverse viruses and manifest distinct antiviral immune responses. Recently in Cell Host & Microbe, Boys et al. demonstrated that bat receptor transporter protein 4 (RTP4) is an innate antiviral effector that inhibits flavivirus replication, revealing an evolutionary arms race between flaviviruses and their hosts
The interpretation of non-Markovian stochastic Schr\"odinger equations as a hidden-variable theory
Do diffusive non-Markovian stochastic Schr\"odinger equations (SSEs) for open
quantum systems have a physical interpretation? In a recent paper [Phys. Rev. A
66, 012108 (2002)] we investigated this question using the orthodox
interpretation of quantum mechanics. We found that the solution of a
non-Markovian SSE represents the state the system would be in at that time if a
measurement was performed on the environment at that time, and yielded a
particular result. However, the linking of solutions at different times to make
a trajectory is, we concluded, a fiction. In this paper we investigate this
question using the modal (hidden variable) interpretation of quantum mechanics.
We find that the noise function appearing in the non-Markovian SSE can
be interpreted as a hidden variable for the environment. That is, some chosen
property (beable) of the environment has a definite value even in the
absence of measurement on the environment. The non-Markovian SSE gives the
evolution of the state of the system ``conditioned'' on this environment hidden
variable. We present the theory for diffusive non-Markovian SSEs that have as
their Markovian limit SSEs corresponding to homodyne and heterodyne detection,
as well as one which has no Markovian limit.Comment: 9 page
Premelting of Thin Wires
Recent work has raised considerable interest on the nature of thin metallic
wires. We have investigated the melting behavior of thin cylindrical Pb wires
with the axis along a (110) direction, using molecular dynamics and a
well-tested many-body potential. We find that---in analogy with cluster
melting---the melting temperature of a wire with radius is lower
than that of a bulk solid, , by . Surface melting
effects, with formation of a thin skin of highly diffusive atoms at the wire
surface, is observed. The diffusivity is lower where the wire surface has a
flat, local (111) orientation, and higher at (110) and (100) rounded areas. The
possible relevance to recent results on non-rupturing thin necks between an STM
tip and a warm surface is addressed.Comment: 10 pages, 4 postscript figures are appended, RevTeX, SISSA Ref.
131/94/CM/S
Microscopic calculation of the spin-dependent neutron scattering lengths on 3He
We report on the spin.dependent neutron scattering length on 3He from a
microscopic calculation of p-3H, n-3He, and d-2H scattering employing the
Argonne v18 nucleon-nucleon potential with and without additional three-nucleon
force. The results and that of a comprehensive R-matrix analysis are compared
to a recent measurement. The overall agreement for the scattering lengths is
quite good. The imaginary parts of the scattering lengths are very sensitive to
the inclusion of three-nucleon forces, whereas the real parts are almost
insensitive.Comment: 9 pages, 1 figur
Two-to-one resonant multi-modal dynamics of horizontal/inclined cables. Part I : theoretical formulation and model validation
This paper is first of the two papers dealingwith analytical investigation of resonant multimodal dynamics due to 2:1 internal resonances in the finite-amplitude free vibrations of horizontal/inclined cables. Part I deals with theoretical formulation and validation of the general cable model. Approximate nonlinear partial differential equations of 3-D coupled motion of small sagged cables - which account for both spatio-temporal variation of nonlinear dynamic tension and system asymmetry due to inclined sagged configurations - are presented. A multidimensional Galerkin expansion of the solution ofnonplanar/planar motion is performed, yielding a complete set of system quadratic/cubic coefficients. With the aim of parametrically studying the behavior of horizontal/inclined cables in Part II [25], a second-order asymptotic analysis under planar 2:1 resonance is accomplished by the method of multiple scales. On accounting for higher-order effectsof quadratic/cubic nonlinearities, approximate closed form solutions of nonlinear amplitudes, frequencies and dynamic configurations of resonant nonlinear normal modes reveal the dependence of cable response on resonant/nonresonant modal contributions. Depending on simplifying kinematic modeling and assigned system parameters, approximate horizontal/inclined cable models are thoroughly validated by numerically evaluating statics and non-planar/planar linear/non-linear dynamics against those of the exact model. Moreover, the modal coupling role and contribution of system longitudinal dynamics are discussed for horizontal cables, showing some meaningful effects due to kinematic condensation
Estimation of Piecewise-Deterministic Trajectories in a Quantum Optics Scenario
The manipulation of individual copies of quantum systems is one of the most groundbreaking experimental discoveries in the field of quantum physics. On both an experimental and a theoretical level, it has been shown that the dynamics of a single copy of an open quantum system is a trajectory of a piecewise-deterministic process. To the best of our knowledge, this application field has not been explored by the literature in applied mathematics, from both probabilistic and statistical perspectives. The objective of this chapter is to provide a self-contained presentation of this kind of model, as well as its specificities in terms of observations scheme of the system, and a first attempt to deal with a statistical issue that arises in the quantum world
Progress in the Prediction of pKa Values in Proteins
The pKa-cooperative aims to provide a forum for experimental and theoretical researchers interested in protein pKa values and protein electrostatics in general. The first round of the pKa-cooperative, which challenged computational labs to carry out blind predictions against pKas experimentally determined in the laboratory of Bertrand Garcia-Moreno, was completed and results discussed at the Telluride meeting (July 6–10, 2009). This article serves as an introduction to the reports submitted by the blind prediction participants that will be published in a special issue of PROTEINS: Structure, Function and Bioinformatics. Here, we briefly outline existing approaches for pKa calculations, emphasizing methods that were used by the participants in calculating the blind pKa values in the first round of the cooperative. We then point out some of the difficulties encountered by the participating groups in making their blind predictions, and finally try to provide some insights for future developments aimed at improving the accuracy of pKa calculations
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