142 research outputs found
Nfat5 is involved in the hyperosmotic regulation of Tmem184b:a putative modulator of ibuprofen transport in renal MDCK I cells
Nonionic surfactants increase digoxin absorption in Caco-2 and MDCKII MDR1 cells: Impact on P-glycoprotein inhibition, barrier function, and repeated cellular exposure
Nonionic surfactants modulate the transport activity of ATP-binding cassette (ABC) transporters and solute carriers (SLC):Relevance to oral drug absorption
Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, hPEPT1
Molecular Networks and Macromolecular Molar Mass Distributions for Preliminary Characterization of Danish Craft Beers
Beer is one of the most widely consumed beverages containing up to 200,000 unique small molecules and a largely uncharacterized macromolecular and particulate space. The chemical profiling of beer is difficult due to its complex nature. To address this issue, we have used various state-of-the-art methods to determine the physicochemical characteristics of beer. Specifically, we have successfully generated an LC-MS-based molecular network with minimal sample preparation to profile indoles in beer and confirmed their presence using 1H-NMR. In addition, we have identified different macromolecular signatures in beer of different colors by utilizing AF4-MALS. These preliminary findings lay the foundation for further research on the physicochemical nature of beer
High-dose etoposide formulations do not saturate intestinal P-glycoprotein:Development, stability, and pharmacokinetics in Sprague-Dawley rats
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