Exploring Patterns of Dynamic Size Changes of Lesions after Hepatic Microwave Ablation in an In Vivo Porcine Model

Microwave ablation (MWA) is a type of minimally invasive cancer therapy that uses heat to induce necrosis in solid tumours. Inter- and post-ablational size changes can influence the accuracy of control imaging, posing a risk of incomplete ablation. The present study aims to explore post-ablation 3D size dynamics in vivo using computed tomography (CT). Ten MWA datasets obtained in nine healthy pigs were used. Lesions were subdivided along the z-axis with an additional planar subdivision into eight subsections. The volume of the subsections was analysed over different time points, subsequently colour-coded and three-dimensionally visualized. A locally weighted polynomial regression model (LOESS) was applied to describe overall size changes, and Student's t-tests were used to assess statistical significance of size changes. The 3D analysis showed heterogeneous volume changes with multiple small changes at the lesion margins over all time points. The changes were pronounced at the upper and lower lesion edges and characterized by initially eccentric, opposite swelling, followed by shrinkage. In the middle parts of the lesion, we observed less dimensional variations over the different time points. LOESS revealed a hyperbolic pattern for the volumetric changes with an initially significant volume increase of 11.6% (111.6% of the original volume) over the first 32 minutes, followed by a continuous decrease to 96% of the original volume (p < 0.05)

Improved Visualization of the Necrotic Zone after Microwave Ablation Using Computed Tomography Volume Perfusion in an In Vivo Porcine Model

After hepatic microwave ablation, the differentiation between fully necrotic and persistent vital tissue through contrast enhanced CT remains a clinical challenge. Therefore, there is a need to evaluate new imaging modalities, such as CT perfusion (CTP) to improve the visualization of coagulation necrosis. MWA and CTP were prospectively performed in five healthy pigs. After the procedure, the pigs were euthanized, and the livers explanted. Orthogonal histological slices of the ablations were stained with a vital stain, digitalized and the necrotic core was segmented. CTP maps were calculated using a dual-input deconvolution algorithm. The segmented necrotic zones were overlaid on the DICOM images to calculate the accuracy of depiction by CECT/CTP compared to the histological reference standard. A receiver operating characteristic analysis was performed to determine the agreement/true positive rate and disagreement/false discovery rate between CECT/CTP and histology. Standard CECT showed a true positive rate of 81% and a false discovery rate of 52% for display of the coagulation necrosis. Using CTP, delineation of the coagulation necrosis could be improved significantly through the display of hepatic blood volume and hepatic arterial blood flow (p < 0.001). The ratios of true positive rate/false discovery rate were 89%/25% and 90%/50% respectively. Other parameter maps showed an inferior performance compared to CECT

Overview of the IWSLT 2017 Evaluation Campaign

The IWSLT 2017 evaluation campaign has organised three tasks. The Multilingual task, which is about training machine translation systems handling many-to-many language directions, including so-called zero-shot directions. The Dialogue task, which calls for the integration of context information in machine translation, in order to resolve anaphoric references that typically occur in human-human dialogue turns. And, finally, the Lecture task, which offers the challenge of automatically transcribing and translating real-life university lectures. Following the tradition of these reports, we will described all tasks in detail and present the results of all runs submitted by their participants

Development of an Electro-Optical Longitudinal Bunch Profile Monitor at KARA Towards a Beam Diagnostics Tool for FCC-ee

The Karlsruhe Research Accelerator (KARA) at KIT features an electro-optical (EO) near-field diagnostics setup to conduct turn-by-turn longitudinal bunch profile measurements in the storage ring using electro-optical spectral decoding (EOSD). Within the Future Circular Collider Innovation Study (FCCIS) an EO monitor using the same technique is being conceived to measure the longitudinal profile and center-of-charge of the bunches in the future electron-positron collider FCC-ee. This contribution provides an overview of the EO near-field diagnostics at KARA and discusses the development and its challenges towards an effective beam diagnostics concept for the FCC-ee

Measuring the Coherent Synchrotron Radiation Far Field with Electro-Optical Techniques

For measuring the temporal profile of the coherent synchrotron radiation (CSR) a setup based on electro-optical spectral decoding (EOSD) will be installed as part of the sensor network at the KIT storage ring KARA (Karlsruhe Research Accelerator). The EOSD technique allows a single-shot, phase sensitive measurement of the complete spectrum of the CSR far field radiation at each turn. Therefore, the dynamics of the bunch evolution, e.g. the microbunching, can be observed in detail. Especially, in synchronized combination with the already established near-field EOSD, this method could provide deeper insights in the interplay of bunch profile and CSR generation for each individual electron bunch. For a successful implementation of the EOSD single shot setup, measurements with electro-optical sampling (EOS) are performed. With EOS the THz pulse shape is scanned over several turns by shifting the delay of laser and THz pulse. In this contribution different steps towards the installation of the EOSD far field setup are summarized

Benchmarking Deep Learning Models for Tooth Structure Segmentation.

A wide range of deep learning (DL) architectures with varying depths are available, with developers usually choosing one or a few of them for their specific task in a nonsystematic way. Benchmarking (i.e., the systematic comparison of state-of-the art architectures on a specific task) may provide guidance in the model development process and may allow developers to make better decisions. However, comprehensive benchmarking has not been performed in dentistry yet. We aimed to benchmark a range of architecture designs for 1 specific, exemplary case: tooth structure segmentation on dental bitewing radiographs. We built 72 models for tooth structure (enamel, dentin, pulp, fillings, crowns) segmentation by combining 6 different DL network architectures (U-Net, U-Net++, Feature Pyramid Networks, LinkNet, Pyramid Scene Parsing Network, Mask Attention Network) with 12 encoders from 3 different encoder families (ResNet, VGG, DenseNet) of varying depth (e.g., VGG13, VGG16, VGG19). On each model design, 3 initialization strategies (ImageNet, CheXpert, random initialization) were applied, resulting overall into 216 trained models, which were trained up to 200 epochs with the Adam optimizer (learning rate = 0.0001) and a batch size of 32. Our data set consisted of 1,625 human-annotated dental bitewing radiographs. We used a 5-fold cross-validation scheme and quantified model performances primarily by the F1-score. Initialization with ImageNet or CheXpert weights significantly outperformed random initialization (P < 0.05). Deeper and more complex models did not necessarily perform better than less complex alternatives. VGG-based models were more robust across model configurations, while more complex models (e.g., from the ResNet family) achieved peak performances. In conclusion, initializing models with pretrained weights may be recommended when training models for dental radiographic analysis. Less complex model architectures may be competitive alternatives if computational resources and training time are restricting factors. Models developed and found superior on nondental data sets may not show this behavior for dental domain-specific tasks