Expression of la Antigens on T and B Cells and their Relationship to Immune-Response Functions

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73337/1/j.1600-065X.1976.tb00217.x.pd

Writing a successful grant application

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25553/1/0000095.pd

Major histocompatibility complex regulation of the immune response

The ability of an organism to distinguish self from nonself is determined by a cluster of genes located in the major histocompatibility complex. Recent advances in molecular genetics and cellular immunology have begun to elucidate the mechanisms responsible for immune response regulation. In this review article, the genetic organization of the murine and human major histocompatibility complexes and the manner by which their gene products modulate immune responsiveness are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25606/1/0000153.pd

Aldonate coupling, a simple procedure for the preparation of carbohydrate-protein conjugates for studies of carbohydrate-binding proteins

Aldonate coupling a new, high-yield method for conjugation of reducing oligosaccharides to proteins is described. It involves oxidation of the oligosaccharides to their corresponding aldonic acids followed by coupling to amino functions of proteins by activation of carboxyl groups with a water-soluble carbodiimide derivative. The immunochemical properties of some of these synthetic glycoproteins were assessed using several plant agglutinins (lectins) as well as antibodies raised to the conjugates. The scope and limitation of the method are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/21712/1/0000104.pd

Constant intraperitoneal 5‐fluorouracil infusion through a totally implanted system

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109794/1/cptclpt198412.pd

The relationship of the major murine histocompatibility region associated IA antigens to mitogen responses

Genes located in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on subpopulations of T and B cells. Specific anti-Ia serum plus rabbit complement removed the B-lymphocyte population responsive to the mitogen LPS and the subpopulation of T cells responsive to Con-A. Lymphocytes sensitive to PHA or leucoagglutinin were not removed by anti-Ia serum and complement. Significant inhibition of the proliferative response to LPS was also obtained by brief periods of cell pretreatment with anti-Ia antibodies without complement. This inhibition was specific with the appropriate anti-Ia serum and did not occur with anti-H-2K sera or when cells of a different I region were pretreated.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/21764/1/0000158.pd

Characterization of three new intra- I region recombinant mouse strains, B10.ASR7 ( H-2 as3 ), B10.BAR4 ( H-2 h6 ), and B10.BASR1 ( H-2 as4 )

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46741/1/251_2004_Article_BF00387862.pd

Con A induced suppressor cells: Suppression with I region incompatibility

Allogeneic Con A induced suppressor cells differing in the I and S region but not H-2K or H-2D regions were as efficient as syngeneic cells in suppressing the secondary IgM and IgG response to burro erythrocytes. Con A activated suppressor cells were not sensitive to anti-Ia serum and complement. However, if the spleen cell population was treated with anti-Ia serum and complement before stimulation with Con A, suppressor cells were not generated.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22960/1/0000527.pd

Publisher Correction:Germline de novo mutation clusters arise during oocyte aging in genomic regions with high double-strand-break incidence (Nature Genetics, (2018), 50, 4, (487-492), 10.1038/s41588-018-0071-6)

In the HTML version of the article originally published, the figures for Supplementary Figures 1–15 were incorrect and did not match the correct figures in the PDF of Supplementary Text and Figures. The error has been corrected in the HTML version of the article