Digit ratio (2D:4D) and altruism: evidence from a large, multi-ethnic sample

We look at the links between the Digit Ratio - the ratio of the length of the index finger to the length of the ring finger – for both right and left hands, and giving in a Dictator Game. Unlike previous studies with exclusively Caucasian subjects, we recruited a large, ethnically diverse sample. Our main results are as follows. First, for Caucasian subjects we estimate a significant positive regression coefficient for the right hand digit ratio and a significant negative coefficient for its squared measure. These results replicate the findings of Brañas-Garza et al. (2013), who also observe an inverted U-shaped relationship for Caucasian subjects. Second, we are not able to find any significant association of the right hand digit ratio with giving in the Dictator Game for the other main ethnic groups in our sample. Third, we find no significant association between giving in the Dictator Game and the left hand digit ratio

Essays on group decision making under risk

Economic theory traditionally explains choice under risk through the preferences of the individual, yet many important economic decisions are made by groups. To increase our understanding of the implications of group decisions and enrich our theories accordingly, we need empirical and experimental evidence on groups. Although economists have conducted controlled laboratory experiments on individual choice for many decades, only recently have researchers begun to use the experimental method to study group decisions under risk. This thesis contributes to the study of group decision making under risk by providing a cross-disciplinary review of the growing literature on this topic, followed by three experiments on risk-taking by groups. The first experiment investigates the role of communication and peer effects, the second experiment investigates group composition, and the final experiment focuses on information sharing in groups

Sending Out an SMS: The Impact of Automatically Enrolling Consumers Into Overdraft Alerts

Incidental charges incurred by UK consumers on their Personal Current Account (PCA) are steep, especially for small amounts of unplanned borrowing and unpaid items. A recent policy mandates major UK banks to send consumers a text message alert of impending charges, allowing them to act before they incur a charge. Using a unique, large and detailed dataset covering the transactions of 1.5 million consumers across 6 banks, and by looking at large-scale automatic enrolment exercises carried out by two major banks, we estimate the effect of automatically enrolling consumers into these alerts. We find that automatic enrolment into alerts has large effects on charges: (i) automatic enrolment into unpaid item alerts (that inform customers of retry periods) reduces charges by 21-24% and (ii) automatic enrolment into unarranged overdraft alerts reduces charges by 25%. We also estimate average treatment effects for different types of consumers, grouped by their pre-alerts level of incidental charges (rare, occasional or heavy), and find that the benefits of automatic enrolment differ markedly between types of consumers. Those who rarely incur charges can avoid as much as half of charges thanks to alerts, whereas heavy users still incur substantial charges after automatic enrolment. We find strikingly similar patterns across the two banks, for both unpaid item and unarranged overdraft charges, providing reassurance that these findings are not specific to a particular customer base or firm implementation

Experimental and self-reported measures of risk taking and digit ratio (2D:4D): evidence from a large, systematic study

We systematically investigate the links between the digit ratio (2D:4D)—a biomarker for prenatal testosterone exposure—and two measures of individual risk taking: (i) risk preferences (RP) over lotteries with real monetary incentives and (ii) self‐reported risk attitude (RA). We find that both the right‐hand and the left‐hand digit ratio are significantly associated with RP: Subjects with lower digit ratios tend to choose riskier lotteries. Neither digit ratio, however, is associated with self‐reported RA

‘Born this Way’? Prenatal Exposure to Testosterone May Determine Behavior in Competition and Conflict

It is documented that fetal exposure to sexual hormones has long lasting effects on human behavior. The second-to-fourth digit ratio (DR) is a putative marker for prenatal exposure to testosterone (compared to estrogens) while in uterus, with higher relative exposure to testosterone resulting in a lower DR. Although the existing literature documents the correlation of DR with various decisions, and testosterone has been related to competitive behaviors, little research has studied the effect of DR on competition in conflict situations where skills do not matter. We investigate this question in the laboratory. Based on a previously obtained large sample of student subjects, we selectively invite subjects to the laboratory if their right-hand DR is in the top (High type) or bottom (Low type) tercile for their gender. Unbeknownst to the subjects, we perform a controlled match of High and Low types as opponents in a 2-person Tullock contest. We find that Low type (higher exposure to testosterone) males expend significantly higher conflict effort than High type males, that is, they are more aggressive, which reduces their opponents’ earnings. Among females, however, everyone is more aggressive against the High type (who respond less aggressively). These results can partially be explained through high joy of winning and/or spitefulness for Low type males, and high spitefulness for Low type females. This investigation sheds light on the importance of biological aspects in the ex-ante determinants of conflict, and on contest design

A framework for understanding outcomes of integrated care programs for the hospitalised elderly

__Abstract__ __Introduction__: Integrated care has emerged as a new strategy to enhance the quality of care for hospitalised elderly. Current models do not provide insight into the mechanisms underlying integrated care delivery. Therefore, we developed a framework to identify the underlying mechanisms of integrated care delivery. We should understand how they operate and interact, so that integrated care programmes can enhance the quality of care and eventually patient outcomes. Theory and methods: Interprofessional collaboration among professionals is considered to be critical in integrated care delivery due to many interdependent work requirements. A review of integrated care components brings to light a distinction between the cognitive and behavioural components of interprofessional collaboration. __Results__: Effective integrated care programmes combine the interactin

Understanding implementation of comprehensive geriatric care programs: a multiple perspective approach is preferred

Background: The Prevention and Reactivation Care Program (PReCaP) provides a novel approach targeting hospital-related functional decline among elderly patients. Despite the high expectations, the PReCaP was not effective in preventing functional decline (ADL and iADL) among older patients. Although elderly PReCaP patients demonstrated slightly better cognitive functioning (Mini Mental State Examination; 0.4 [95% confidence interval (CI) 0.2–0.6]), lower depression (Geriatric Depression Scale 15; –0.9 [95% –1.1 to –0.6]), and higher perceived health (Short-form 20; 5.6 [95% CI 2.8–8.4]) 1 year after admission than control patients, the clinical relevance was limited. Therefore, this study aims to identify factors impacting on the effectiveness of the implementation of the PReCaPand geriatric care ‘as usual’. Methods: We conducted semi-structured interviews with 34 professionals working with elderly patients in three hospitals, selected for their comparable patient case mix and different levels of geriatric care. Five non-participatory observations were undertaken during multidisciplinary meetings. Patient files (n = 42), hospital protocols, and care plans were screened for elements of geriatric care. Clinical process data were analysed for PReCaP components. Results: The establishment of a geriatric unit and employment of geriatricians demonstrates commitment to geriatric care in hospital A. Although admission processes are comparable, early identification of frail elderly patients only takes place in hosptial A. Furthermore, nursing care in the hospital A geriatric unit excels with regard to maximizing patient independency, an important predictor for hospital-related functional decline. Transfer nurses play a key role in arranging post-discharge geriatric follow-up care. Geriatric consultations are performed by g

The Prevention and Reactivation Care Program: intervention fidelity matters.

The Prevention and Reactivation Care Program (PReCaP) entails an innovative multidisciplinary, integrated and goal oriented approach aimed at reducing hospital related functional decline among elderly patients. Despite calls for process evaluation as an essential component of clinical trials in the geriatric care field, studies assessing fidelity lag behind the number of effect studies. The threefold purpose of this study was (1) to systematically assess intervention fidelity of the hospital phase of the PReCaP in the first year of the intervention delivery; (2) to improve our understanding of the moderating factors and modifications affecting intervention fidelity; and (3) to explore the feasibility of the PReCaP fidelity assessment in view of the modifications. Based on the PReCaP description we developed a fidelity instrument incorporating nineteen (n=19) intervention components. A combination of data collection methods was utilized, i.e. data collection from patient records and individual Goal Attainment Scaling care plans, in-depth interviews with stakeholders, and non-participant observations. Descriptive analysis was performed to obtain levels of fidelity of each of the nineteen PReCaP components. Moderating factors were identified by using the Conceptual Framework for Implementation Fidelity. Ten of the nineteen intervention components were always or often delivered to the group of twenty elderly patients. Moderating factors, suc

Targetclone: A multi-sample approach for reconstructing subclonal evolution of tumors

Most tumors are composed of a heterogeneous population of subclones. A more detailed insight into the subclonal evolution of these tumors can be helpful to study progression and treatment response. Problematically, tumor samples are typically very heterogeneous, making deconvolving individual tumor subclones a major challenge. To overcome this limitation, reducing heterogeneity, such as by means of microdissections, coupled with targeted sequencing, is a viable approach. However, computational methods that enable reconstruction of the evolutionary relationships require unbiased read depth measurements, which are commonly challenging to obtain in this setting. We introduce TargetClone, a novel method to reconstruct the subclonal evolution tree of tumors from single-nucleotide polymorphism allele frequency and somatic single-nucleotide variant measurements. Furthermore, our method infers copy numbers, alleles and the fraction of the tumor component in each sample. TargetClone was specifically designed for targeted sequencing data obtained from microdissected samples. We demonstrate that our method obtains low error rates on simulated data. Additionally, we show that our method is able to reconstruct expected trees in a testicular germ cell cancer and ovarian cancer dataset. The TargetClone package including tree visualization is written in Python and is publicly available at https://github.com/UMCUGenetics/targetclone