Towards design of prognostics and health management solutions for maritime assets

With increase in competition between OEMs of maritime assets and operators alike, the need to maximize the productivity of an equipment and increase operational efficiency and reliability is increasingly stringent and challenging. Also, with the adoption of availability contracts, maritime OEMs are becoming directly interested in understanding the health of their assets in order to maximize profits and to minimize the risk of a system's failure. The key to address these challenges and needs is performance optimization. For this to be possible it is important to understand that system failure can induce downtime which will increase the total cost of ownership, therefore it is important by all means to minimize unscheduled maintenance. If the state of health or condition of a system, subsystem or component is known, condition-based maintenance can be carried out and system design optimization can be achieved thereby reducing total cost of ownership. With the increasing competition with regards to the maritime industry, it is important that the state of health of a component/sub-system/system/asset is known before a vessel embarks on a mission. Any breakdown or malfunction in any part of any system or subsystem on board vessel during the operation offshore will lead to large economic losses and sometimes cause accidents. For example, damages to the fuel oil system of vessel's main engine can result in huge downtime as a result of the vessel not being in operation. This paper presents a prognostic and health management (PHM) development process applied on a fuel oil system powering diesel engines typically used in various cruise and fishing vessels, dredgers, pipe laying vessels and large oil tankers. This process will hopefully enable future PHM solutions for maritime assets to be designed in a more formal and systematic way

Comparison of different classification algorithms for fault detection and fault isolation in complex systems

Due to the lack of sufficient results seen in literature, feature extraction and classification methods of hydraulic systems appears to be somewhat challenging. This paper compares the performance of three classifiers (namely linear support vector machine (SVM), distance-weighted k-nearest neighbor (WKNN), and decision tree (DT) using data from optimized and non-optimized sensor set solutions. The algorithms are trained with known data and then tested with unknown data for different scenarios characterizing faults with different degrees of severity. This investigation is based solely on a data-driven approach and relies on data sets that are taken from experiments on the fuel system. The system that is used throughout this study is a typical fuel delivery system consisting of standard components such as a filter, pump, valve, nozzle, pipes, and two tanks. Running representative tests on a fuel system are problematic because of the time, cost, and reproduction constraints involved in capturing any significant degradation. Simulating significant degradation requires running over a considerable period; this cannot be reproduced quickly and is costly

Avancées sur la source, la taille et la nature des particules microbiennes aéroportées présentes dans l'environnement intérieur

L'exposition à certaines particules fongiques et bactéries présentes dans les aérosols de l'environnement intérieur a été associée au développement ou à l'exacerbation d'affections respiratoires telles que l'asthme, la rhinite allergique ou encore l'aspergillose (1-4). Le réservoir principal identifié dans cet environnement pour les bactéries aéroportées est constitué par les habitants eux-mêmes, alors que celui des particules fongiques est l'environnement extérieur, ou, lorsque les conditions sont réunies, l'environnement intérieur (5-7). Néanmoins, la nature et la taille de ces particules fongiques, ainsi que l'impact de l'occupation humaine sur ces paramètres n'ont été que peu explorés. Les articles de cette note s'intéressent justement à ces aspects et illustrent l'importance de leur prise en compte dans l'évaluation du risque d'exposition aux microorganismes dans l'environnement intérieur. L'étude de Hospodsky et coll. (2014) apporte une information quantitative sur le niveau d'émission de bactéries et particules fongiques résultant d'une occupation humaine dans des environnements intérieurs sains. Alors que l'étude de Afanou et coll. (2014) montre la complexité des particules fongiques qui peuvent être générées dans l'environnement intérieur, différentes espèces de moisissures pouvant participer en proportions différentes au nombre de particules submicroniques1 grâce à leurs fragments de spores ou hyphes

L'exposition aux moisissures des enfants en milieu citadin et rural

L'asthme est une des maladies chroniques des plus fréquentes chez l'enfant qui touche 7,6 à 10,7 % de la population infantile française (ISAAC, 1998). Un des facteurs étiologiques impliqué dans cette pathologie est les moisissures présentes dans l'habitat. Néanmoins, il reste toujours à clarifier quelle est la fenêtre d'exposition la plus critique au cours de l'enfance et à comprendre le mécanisme de cette étiologie. En effet, des effets contradictoires ont été associés à l'exposition précoce des enfants aux moisissures. L'exposition à une espèce de moisissure dominante augmente l'incidence de l'asthme chez le jeune enfant, alors que l'exposition à des bioaérosols riches et diversifiés en micro-organismes, comme ceux présent dans les fermes, le diminue. Ces deux effets font l'objet des deux études choisies dans cette note. [Auteure]]]> Asthma ; Child ; Respiratory Tract Diseases ; Fungi ; Rhinitis, Allergic, Perennial fre oai:serval.unil.ch:BIB_C31B6241296B 2022-05-07T01:26:31Z openaire documents <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_C31B6241296B Long-acting antiretrovirals: a new era for the management and prevention of HIV infection. info:doi:10.1093/jac/dkab324 info:eu-repo/semantics/altIdentifier/doi/10.1093/jac/dkab324 info:eu-repo/semantics/altIdentifier/pmid/34499731 Thoueille, P. Choong, E. Cavassini, M. Buclin, T. Decosterd, L.A. info:eu-repo/semantics/review article 2022-02-02 The Journal of antimicrobial chemotherapy, vol. 77, no. 2, pp. 290-302 info:eu-repo/semantics/altIdentifier/eissn/1460-2091 urn:issn:0305-7453 <![CDATA[The long-acting antiretroviral cabotegravir and rilpivirine combination has just received FDA, EMA and Health Canada approval. This novel drug delivery approach is about to revolutionize the therapy of people living with HIV, decreasing the 365 daily pill burden to only six intramuscular injections per year. In addition, islatravir, a first-in-class nucleoside reverse transcriptase translocation inhibitor, is intended to be formulated as an implant with a dosing interval of 1 year or more. At present, long-acting antiretroviral therapies (LA-ARTs) are given at fixed standard doses, irrespectively of the patient's weight and BMI, and without consideration for host genetic and non-genetic factors likely influencing their systemic disposition. Despite a few remaining challenges related to administration (e.g. pain, dedicated medical procedure), the development and implementation of LA-ARTs can overcome long-term adherence issues by improving patients' privacy and reducing social stigma associated with the daily oral intake of anti-HIV treatments. Yet, the current 'one-size-fits-all' approach does not account for the recognized significant inter-individual variability in LA-ART pharmacokinetics. Therapeutic drug monitoring (TDM), an important tool for precision medicine, may provide physicians with valuable information on actual drug exposure in patients, contributing to improve their management in real life. The present review aims to update the current state of knowledge on these novel promising LA-ARTs and discusses their implications, particularly from a clinical pharmacokinetics perspective, for the future management and prevention of HIV infection, issues of ongoing importance in the absence of curative treatment or an effective vaccine