16 research outputs found
FDR and the Jews. By Richard Breitman and Allan J. Lichtman. Cambridge, MA: The Belknap Press of Harvard University Press. 2013. Pp. viii + 410. Cloth $29.95. ISBN 978-0-674-05026-6.
Stefan Ihrig, Atatürk in the Nazi Imagination (Cambridge, Mass.: Belknap Press of Harvard University Press, 2014). Pp. 311. $29.95 cloth. ISBN: 9781674368378.
Resistance and Self-Defence : Zionism and Antisemitism in Inter-War Germany.
Manuscript about Zionism in Germany as a form of Jewish resistance against Nazism before World War II.Synopsis in fil
Convergence: The Classic Case Nazi Germany, Anti-Semitism and Anti-Zionism during World War II
Modeling lymphangiogenesis in a three-dimensional culture system
peer reviewedUnraveling the molecular mechanisms of lymphangiogenesis is hampered by the lack of appropriate in vitro models of three-dimensional (3D) lymph vessel growth which can be used to exploit the potential of available transgenic mice. We developed a potent reproducible and quantifiable 3D-culture system of lymphatic endothelial cells, the lymphatic ring assay, bridging the gap between 2D-in vitro and in vivo models of lymphangiogenesis. Mice thoracic duct fragments are embedded in a collagen gel leading to the formation of lymphatic capillaries containing a lumen as assessed by electron microscopy and immunostaining. This assay phenocopies the different steps of lymphangiogenesis, including the spreading from a preexisting vessel, cell proliferation, migration and differentiation into capillaries. Our study provides evidence for the implication of an individual matrix metalloproteinase, MMP-2, during lymphangiogenesis. The lymphatic ring assay is a robust, quantifiable and reproducible system which offers new opportunities for rapid identification of unknown regulators of lymphangiogenesis