The battle to end fake news: A qualitative content analysis of Facebook announcements on how it combats disinformation

The recent spread of online disinformation has been profound and has played a central role in the growth of populist sentiments around the world. Facilitating its progression has been politically and economically motivated culprits who have ostensibly taken advantage of the digital freedoms available to them. At the heart of these freedoms lie social media organisations that only a few years earlier techno-optimists were identifying as catalysts of an enhanced digital democracy. In order to curtail the erosion of information, policy reform will no doubt be essential. The UK's Department of Digital, Culture, Media and Sport Disinformation and ‘fake news’ Report and Cairncross Review, and the European Commission's Report on Disinformation are three recent examples seeking to investigate how precisely such reform policy might be implemented. Just as important is how social media organisations take on more responsibility and apply self-regulating mechanisms that stifle disinformation across their platforms (something the aforementioned reports identify). Doing so will go a long way in restoring legitimacy in these significant institutions. Facebook (which includes Instagram and Whatsapp), is the largest social media organisation in the world and must primarily bear the burden of this responsibility. The purpose of this article is to offer a descriptive account of Facebook's public announcements regarding how it tackles disinformation and fake news. Based on a qualitative content analysis covering the period November 16th 2016–March 4th 2019, this article will set out some groundwork on how to hold social media platforms more accountable for how they handle disinformation

EU digital economy competition policy: From ex-post to ex-ante. The case of Alphabet, Amazon, Apple, and Meta

Since 2007, the European Commission (EC) has opened numerous competition cases regarding Alphabet, Amazon, Apple, and Meta (AAAM). Enforcement, however, has remained elusive, prompting a new regulatory paradigm in the EU known as the Digital Markets Act. In this study, we analyze the EC’s competition policy approach regarding big tech with an emphasis on AAAM. Rather than implementing a consumer welfare friendly neoclassic economics analysis, we adopt a critical political economy of communications (CPE) approach to analyze these cases. The article explores whether EU competition policy does enough to yield the required measures to preserve a healthy digital economy sector for political and social welfare as much as for consumer welfare

Effect of different biopolymer-based structured systems on the survival of probiotic strains during storage and in vitro digestion

BACKGROUND: This study aimed to evaluate the protective effect of different biopolymer systems on the viability of two probiotics (Lactobacillus rhamnosus and Streptococcus thermophilus) during storage and in vitro digestion. Methylcellulose (MC), sodium alginate (SA), and whey protein (WP)-based structures were designed and characterized in terms of pH, rheological properties, and visual appearance. RESULTS: The results highlighted that the WP-system ensured probiotic protection during both storage and in vitro digestion. This result was attributed to a combined effect of the physical barrier offered by the protein gel network and whey proteins as a nutrient for microbes. On the other hand, surprisingly, the viscous methylcellulose-based system was able to guarantee good microbial viability during storage. However, this was not confirmed during in vitro digestion. The opposite results were obtained for sodium alginate beads. CONCLUSION: The results suggest that the capacity of a polymeric structure to protect probiotic bacteria is a combination of structural organization and system formulation. \ua9 2020 Society of Chemical Industry

Exogenous ghrelin attenuates endotoxin fever in rats

AbstractGhrelin is a gut-derived peptide that plays a role in energy homeostasis. Recent studies have implicated ghrelin in systemic inflammation, showing increased plasma ghrelin levels after endotoxin (lipopolysaccharide, LPS) administration. The aims of this study were (1) to test the hypothesis that ghrelin administration affects LPS-induced fever; and (2) to assess the putative effects of ghrelin on plasma corticosterone secretion and preoptic region prostaglandin (PG) E2 levels in euthermic and febrile rats. Rats were implanted with a temperature datalogger capsule in the peritoneal cavity to record body core temperature. One week later, they were challenged with LPS (50μg/kg, intraperitoneal, i.p.) alone or combined with ghrelin (0.1mg/kg, i.p.). In another group of rats, plasma corticosterone and preoptic region PGE2 levels were measured 2h after injections. In euthermic animals, systemic administration of ghrelin failed to elicit any thermoregulatory effect, and caused no significant changes in basal plasma corticosterone and preoptic region PGE2 levels. LPS caused a typical febrile response, accompanied by increased plasma corticosterone and preoptic PGE2 levels. When LPS administration was combined with ghrelin fever was attenuated, corticosterone secretion further increased, and the elevated preoptic PGE2 levels were relatively reduced, but a correlation between these two variables (corticosterone and PGE2) failed to exist. The present data add ghrelin to the neurochemical milieu controlling the immune/thermoregulatory system acting as an antipyretic molecule. Moreover, our findings also support the notion that ghrelin attenuates fever by means of a direct effect of the peptide reducing PGE2 production in the preoptic region

Antidoping programme and biological monitoring before and during the 2014 FIFA World Cup Brazil.

BACKGROUND: The FIFA has implemented an important antidoping programme for the 2014 FIFA World Cup. AIM: To perform the analyses before and during the World Cup with biological monitoring of blood and urine samples. METHODS: All qualified players from the 32 teams participating in the World Cup were tested out-of-competition. During the World Cup, 2-8 players per match were tested. Over 1000 samples were collected in total and analysed in the WADA accredited Laboratory of Lausanne. RESULTS: The quality of the analyses was at the required level as described in the WADA technical documents. The urinary steroid profiles of the players were stable and consistent with previously published papers on football players. During the competition, amphetamine was detected in a sample collected on a player who had a therapeutic use exemption for attention deficit hyperactivity disorder. The blood passport data showed no significant difference in haemoglobin values between out-of-competition and postmatch samples. CONCLUSIONS: Logistical issues linked to biological samples collection, and the overseas shipment during the World Cup did not impair the quality of the analyses, especially when used as the biological passport of football players

Steroid profiling by UHPLC-MS/MS in dried blood spots collected from healthy women with and without testosterone gel administration.

The quantification of a large panel of endogenous steroids in serum by LC-MS/MS represents a powerful clinical tool for the screening or diagnosis of diverse endocrine disorders. This approach has also demonstrated excellent sensitivity for the detection of testosterone misuse in the anti-doping field, especially in female athlete population. In both situations, the use of dried blood spots (DBS) could provide a viable alternative to invasive venous blood collection. Here, the evaluation of DBS sampling for the quantification of a panel of endogenous steroids using UHPLC-MS/MS is described. The UHPLC-MS/MS method was validated for quantitative analysis of eleven free and eight conjugated steroids and was then used for the analysis of DBS samples collected in 14 healthy women during a normal menstrual cycle (control phase) followed by a 28-days testosterone gel treatment (treatment phase). Results were compared with those obtained from serum matrix. Satisfactory performance was obtained for all compounds in terms of selectivity, linearity, accuracy, precision, combined uncertainty, stability as well as extraction recovery and matrix effects. In control phase, high correlation was observed between DBS and serum concentrations for most compounds. In treatment phase, higher testosterone concentrations were observed in capillary than in venous DBS, suggesting a possible interference resulting from testosterone contamination on finger(s) used for gel application. Steroid profiling in capillary DBS represents a simple and efficient strategy for monitoring endogenous steroid concentrations and their fluctuation in clinical context of steroid-related disorders, or for the detection of testosterone abuse in anti-doping

Straightforward quantification of endogenous steroids with liquid chromatography-tandem mass spectrometry: Comparing calibration approaches.

Different calibration strategies are used in liquid chromatography hyphenated to mass spectrometry (LC-MS) bioanalysis. Currently, the surrogate matrix and surrogate analyte represent the most widely used approaches to compensate for the lack of analyte-free matrices in endogenous compounds quantification. In this context, there is a growing interest in rationalizing and simplifying quantitative analysis using a one-point concentration level of stable isotope-labeled (SIL) standards as surrogate calibrants. Accordingly, an internal calibration (IC) can be applied when the instrument response is translated into analyte concentration via the analyte-to-SIL ratio performed directly in the study sample. Since SILs are generally used as internal standards to normalize variability between authentic study sample matrix and surrogate matrix used for the calibration, IC can be calculated even if the calibration protocol was achieved for an external calibration (EC). In this study, a complete dataset of a published and fully validated method to quantify an extended steroid profile in serum was recomputed by adapting the role of SIL internal standards as surrogate calibrants. Using the validation samples, the quantitative performances for IC were comparable with the original method, showing acceptable trueness (79%-115%) and precision (0.8%-11.8%) for the 21 detected steroids. The IC methodology was then applied to human serum samples (n = 51) from healthy women and women diagnosed with mild hyperandrogenism, showing high agreement (R <sup>2</sup> > 0.98) with the concentrations obtained using the conventional quantification based on EC. For IC, Passing-Bablok regression showed proportional biases between -15.0% and 11.3% for all quantified steroids, with an average difference of -5.8% compared to EC. These results highlight the reliability and the advantages of implementing IC in clinical laboratories routine to simplify quantification in LC-MS bioanalysis, especially when a large panel of analytes is monitored

Improved Nearside-Farside Decomposition of Elastic Scattering Amplitudes

A simple technique is described, that provides improved nearside-farside (NF) decompositions of elastic scattering amplitudes. The technique, involving the resummation of a Legendre partial wave series, reduces the importance of unphysical contributions to NF subamplitudes, which can arise in more conventional NF decompositions. Applications are made to a strong absorption model and to a $^{16}$O + $^{12}$C optical potential at $E_{\text{lab}} = 132$ MeV.Comment: 5 pages, 2 figure