Parameters and notations for the mathematical model.

<p>Parameters and notations for the mathematical model.</p

Mutation rate estimates from Table 1 of [21].

<p>Mutation rate estimates from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0101434#pone-0101434-t001" target="_blank">Table 1</a> of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0101434#pone.0101434-Werngren1" target="_blank">[21]</a>.</p

Relative biases on estimates of a mutation rate.

<p>Relative biases are plotted as a function of the coefficient of variation . The different curves correspond to values of from to . Red curves show biases of the -method. For blue curves, the bias has been corrected by the unbiasing factor (1). The correction maintains the bias under acceptable values even for relatively large and .</p

Estimates of a mutation rate on 1000 samples of size 50 of pairs mutant counts – final counts.

<p>The horizontal line marks the true value. The first two boxplots correspond the traditional - and ML methods, which estimate the expected number of mutations from the sample of mutant counts, then divide by the final number of cells, supposed as known. On the next two boxplots, the estimates have been multiplied by the unbiasing factor (1). The last two boxplots use the full samples of pairs but no prior knowledge on final numbers. The best results are obtained by the maximum likelihood method (last boxplot). The -method (label MLP0) performs nearly as well.</p

Mutation rate estimates from Table 1 of [17].

<p>Mutation rate estimates from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0101434#pone-0101434-t001" target="_blank">Table 1</a> of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0101434#pone.0101434-David1" target="_blank">[17]</a>.</p

Experiment Design.

<p>Definition of abbreviations: J = TMC 207, R = Rifampin, M = Moxifloxacin, H = Isoniazid, Z = Pyrazinamide, A = amikacin, Et = ethionamide.</p><p>Mice were infected intravenously with 1.1×10⁶ of <i>M. tuberculosis</i> H37Rv.</p><p>Day -18: the day after infection, Day 0: start of treatment.</p><p>*Mice kept untreated for mortality assessment.</p><p>All drugs were given 5 times per week at the following doses: J, 25 mg/kg; R, 10 mg/kg; M, 100 mg/kg; H, 25 mg/kg; Z, 150 mg/kg; A, 150 mg/kg; Et, 50 mg/kg.</p

Proportion of mice with positive culture of lung 3 months after treatment completion (relapse).^*

<p>*Lung CFU count at start of treatment (D0): 7.1 log10 CFU.</p><p>Definition of abbreviations: J = TMC 207, R = Rifampin, M = Moxifloxacin, H = Isoniazid, Z = Pyrazinamide, A = amikacin, Et = ethionamide.</p>a<p>significantly more relapses than RHZ (p<0.05).</p>b<p>not significantly different from RHZ (p>0.05).</p

Results of footpad cultures during the treatment of mice infected with <i>M</i>. <i>ulcerans</i> and relapse rate after treatment completion.

<p>Results of footpad cultures during the treatment of mice infected with <i>M</i>. <i>ulcerans</i> and relapse rate after treatment completion.</p

Evolution of the average lesion indexes in the control and treated groups.

<p>Evolution of the average lesion indexes in the control and treated groups.</p

Multiplication of <i>M</i>. <i>leprae</i> organisms in nude mice to determine minimal effective dose of BDQ administered orally active against <i>M</i>. <i>leprae</i> and the benefit of the combination of CFZ and BDQ.

Multiplication of M. leprae organisms in nude mice to determine minimal effective dose of BDQ administered orally active against M. leprae and the benefit of the combination of CFZ and BDQ.</p