Diabetic ketoacidosis at the onset of disease during a national awareness campaign: a 2-year observational study in children aged 0-18 years

After a previous survey on the incidence of diabetic ketoacidosis (DKA) at onset of type 1 diabetes in children in 2013-2014 in Italy, we aimed to verify a possible decline in the incidence of DKA at onset during a national prevention campaign

The Silent Epidemic of Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Children and Adolescents in Italy During the COVID-19 Pandemic in 2020

To compare the frequency of diabetic ketoacidosis (DKA) at diagnosis of type 1 diabetes in Italy during the COVID-19 pandemic in 2020 with the frequency of DKA during 2017-2019

Tratti neostandard nella scrittura formale giovanile. Un'indagine sulle scuole secondarie di Bologna

L’articolo si propone di rilevare il grado di penetrazione delle caratteristiche dell'italiano neo-standard in un corpus di testi scritti in ambito scolastico e indagare, soprattutto, l’atteggiamento degli insegnanti rispetto a queste caratteristiche nell’attività di correzione degli elaborati. La loro reazione rispetto alle caratteristiche innovative è fondamentale perché, in quanto autorità linguistiche, hanno un ruolo significativo nel processo di ri-standardizzazione che caratterizza l'italiano contemporaneo. Il focus della ricerca, dunque, non è rappresentato solo dai testi prodotti dagli studenti, ma, soprattutto, dagli interventi degli insegnanti (e questo rappresenta l’elemento più innovativo della ricerca). L'analisi dei dati raccolti mostra che la norma linguistica trasmessa dalle scuole non tratta in modo uniforme tutte le caratteristiche linguistiche considerate, ma sembra riprodurre le tendenze della comunità linguistica e del suo repertorio: gli insegnanti che hanno partecipato all’indagine, infatti, mostrano atteggiamenti non omogenei rispetto ai tratti neostandard che emergono dagli elaborati scolastici (alcuni insegnanti correggono aspetti che altri insegnanti invece ignorano). Inoltre, i risultati dell'analisi dei dati illustrano che le scuole non promuovono necessariamente usi linguistici conservatori: la mancata correzione sistematica di tratti neo-standard può infatti essere considerata come un implicito e inconsapevole sostegno ad usi linguistici innovatori

Circulating mRNA for epidermal growth factor-like domain 7 (EGFL7) in maternal blood and early intrauterine growth restriction. A preliminary analysis

OBJECTIVE: To evaluate the alteration in epidermal growth factor-like domain 7 (EGFL7) mRNA expression in maternal blood from pregnancies affected by early-onset intrauterine growth restriction (IUGR) at 20-24 weeks. METHOD: Case-control study encompassing six women with pregnancies affected by IUGR (cases) matched in a 1 : 7 ratio for gestational age and fetal gender with 42 controls. We quantified EGFL7 mRNA expression in normal and IUGR patients. Matched rank-sum analysis and multiples of median were used to evaluate differences of the marker of interest between cases and controls. Spearman regression analysis was used to correlate the estimated fetal weight at blood sampling with the EGFL7 mRNA values. RESULTS: The mean observed rank in the IUGR group was significantly higher than that of controls (6.67 vs 4.19, p = 0.01). Pregnancies affected with IUGR exhibited 1.70-fold higher levels of maternal EGFL7 mRNA compared with matched controls (p = 0.014). EGFL7 mRNA values were inversely correlated with estimated fetal weight (Spearman's \u3c1 = -0.429, p = 0.198). CONCLUSION: Early IUGR at 20-24 weeks' gestation is associated with higher values of EGFL7 expression in maternal plasma

Elevated maternal placental protein 13 serum levels at term of pregnancy in postpartum major hemorrhage (>1000\uc2\ua0mLs). A prospective cohort study

Problem: To compare placental protein 13 (PP13) levels in the serum of women with primary postpartum hemorrhage (PPH) with a control population. Methods: A prospective cohort study was conducted between May 2014 and May 2016 and included 435 pregnant women at term (38\uc2\ua0weeks gestation) without any known risk factor and with normal labor. Multiples of median (MoM) were used to evaluate differences of the PP13 values between cases and controls. PP13 concentrations were adjusted for maternal and neonatal weight. Multivariable analysis was used to detect independent contribution of predictors of PPH. Results: Fifteen had a major PPH >1000\uc2\ua0mLs and represented the cases of the study. They were matched with 399 controls. Twenty-one patients who had a minor PPH (500-1000 mLs) were excluded. The mean observed rank in the PPH group was higher than that of controls (28.5 vs 13.5, P-value=.01). PP13 MoM values adjusted for maternal weight were higher than expected being 1.44\uc2\ub10.45 in PPH cases and 1.00\uc2\ub10.59 in controls (P-value.008). This difference was still significant even after adjustment for neonatal weight that represented a confounding variable. Conclusion: Higher PP13 levels are independently associated with major PPH >1000\uc2\ua0mLs