Star polymers rupture induced by constant forces

In this work, we study the breakage process of an unknotted three-arm star-shaped polymer when it is pulled from its free ends by a constant force. The star polymer configuration is described through an array of monomers coupled by anharmonic bonds, while the rupture process is tracked in three-dimensional space by means of Langevin Molecular Dynamics simulations. The interaction between monomers is described by a Morse potential, while a Weeks-Chandler-Anderson energetic contribution accounts for the excluded volume interaction. We explore the effect of the molecular architecture on the distributions of rupture times over a broad interval of pulling forces and star configurations. It was found that the rupture time distribution of the individual star arms is strongly affected by the star configuration imposed by the pulling forces and the length of the arms. We also observed that for large pulling forces the rupture time distributions resemble the dominant features observed for linear polymer chains. The model introduced here provides the basic ingredients to describe the effects of tensile forces on stress-induced degradation of branched macromolecules and polymer networks.Fil: García, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Física del Sur. Universidad Nacional del Sur. Departamento de Física. Instituto de Física del Sur; ArgentinaFil: Febbo, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Física del Sur. Universidad Nacional del Sur. Departamento de Física. Instituto de Física del Sur; ArgentinaFil: Vega, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Física del Sur. Universidad Nacional del Sur. Departamento de Física. Instituto de Física del Sur; ArgentinaFil: Milchev, A.. Bulgarian Academy of Sciences; Bulgari

The role of intermediaries in the synchronization of pulse-coupled oscillators

The role of intermediaries in the synchronization of small groups of light controlled oscillators (LCO) is addressed. A single LCO is a two-time-scale phase oscillator. When pulse-coupling two LCOs, the synchronization time decreases monotonously as the coupling strength increases, independent of the initial conditions and frequency detuning. In this work we study numerically the effects that a third LCO induces to the collective behavior of the system. We analyze the new system by dealing with directed heterogeneous couplings among the units. We report a novel and robust phenomenon, absent when coupling two LCOs, which consists of a discontinuous relationship between the synchronization time and coupling strength or initial conditions. The mechanism responsible for the appearance of such discontinuities is discussed.Comment: 11 pages, 8 figure

Entanglement reduction induced by geometrical confinement in polymer thin films

We report simulation results on melts of entangled linear polymers confined in a free-standing thin film. We study how the geometric constraints imposed by the confinement alter the entanglement state of the system compared to the equivalent bulk system using various observables. We find that the confinement compresses the chain conformation uniaxially, decreasing the volume pervaded by the chain, which in turn reduces the number of the accessible inter-chain contact that could lead to entanglements. This local and non-uniform effect depends on the position of the chain within the film. We also test a recently presented theory that predicts how the number of entanglements decreases with geometrical confinement.Comment: 28 pages, 10 figure

Macrophage phagocytosis of SARS-CoV-2-infected cells mediates potent plasmacytoid dendritic cell activation.

Early and strong interferon type I (IFN-I) responses are usually associated with mild COVID-19 disease, whereas persistent or unregulated proinflammatory cytokine responses are associated with severe disease outcomes. Previous work suggested that monocyte-derived macrophages (MDMs) are resistant and unresponsive to SARS-CoV-2 infection. Here, we demonstrate that upon phagocytosis of SARS-CoV-2-infected cells, MDMs are activated and secrete IL-6 and TNF. Importantly, activated MDMs in turn mediate strong activation of plasmacytoid dendritic cells (pDCs), leading to the secretion of high levels of IFN-α and TNF. Furthermore, pDC activation promoted IL-6 production by MDMs. This kind of pDC activation was dependent on direct integrin-mediated cell‒cell contacts and involved stimulation of the TLR7 and STING signaling pathways. Overall, the present study describes a novel and potent pathway of pDC activation that is linked to the macrophage-mediated clearance of infected cells. These findings suggest that a high infection rate by SARS-CoV-2 may lead to exaggerated cytokine responses, which may contribute to tissue damage and severe disease

Heart rate in professional musicians

<p>Abstract</p> <p>Background</p> <p>Very few studies have analysed heart rate (HR) with regard to music playing, and the scarce evidence available is controversial. The purpose of this study was to analyse the HR response of professional musicians during their real-work activity.</p> <p>Methods</p> <p>Sixty-two voluntary professional musicians (20 women, 42 men), whose ages ranged between 15 and 71 years old, underwent the test while playing their instruments in real life scenarios, i.e. rehearsals, practice and public concerts. The musicians carried Sport Tester PE4000 (Polar^®, Finland) pulsometers to record their HR.</p> <p>In order to compare data from differently aged subjects we calculated their Maximum Theoretical Heart Rate (MTHR). Later on we found out the MTHR percentages (%MTHR) corresponding to the registered HR of each subject in different situations. The value of the MTHR for every musician was obtained by means of the <it>220 – age (in years) </it>formula.</p> <p>Results</p> <p>Throughout the HR recordings, we have observed that musicians present a heightened HR while playing (in soloists, mean and maximum HR were 72% and 85%MTHR, respectively). Cardiac demand is significantly higher in concerts than in rehearsals while performing the same musical piece. The HR curves corresponding to the same musician playing in repeated concerts (with the same programme) were similar.</p> <p>Conclusion</p> <p>The cardiac demand of a professional instrument player is higher than previously described, much greater than what would be expected from a supposedly sedentary activity.</p

PID controller using rapid control prototyping techniques

To analyze the performance of the PID controller in a buck type converter implemented in real time. We begin by designing a continuous controller using the analytical method for calculating PIDs. Pulse width modulation is then used and bifurcation diagrams analyzed to reveal some problems of switching and sampling time. The model converter is then implemented with a PID controller in dSPACE. The experimental results provide detailed requirements of sampling frequency and switching speed, and show the performance of the PID controller. Converters are used in power generation solar systems and conmuted power sources for feed telecommunication devices, smart grids, and other applications

Spectral gradients in central cluster galaxies: further evidence of star formation in cooling flows

We have obtained radial gradients in the spectral features of the lambda 4000-Angstrom break (D(4000)) and Mg(2) for a sample of 11 central cluster galaxies (CCGs): eight in clusters with cooling flows and three in clusters without. After careful removal of the emission lines found within the D(4000) and Mg(2) bandpasses for some objects, the new data strongly confirm the correlations between line-strength indices and the cooling flow phenomenon found in our earlier study. We find that such correlations depend on the presence and characteristics of emission lines in the inner regions of the CCGs. The nuclear indices are correlated with the mass deposition rate ((M) over dot) only when emission lines are found in the central regions of the galaxies. The central D(4000) and Mg(2) indices in cooling flow galaxies without emission lines are completely consistent with the indices measured in CCGs in clusters without cooling flows. CCGs in cooling flow clusters exhibit a clear sequence in the D(4000)-Mg(2) plane, with a neat segregation depending on emission-line type and blue morphology. This sequence can be modelled, using stellar population models with a normal initial mass function (IMF), by a recent (similar to 0.1 Gyr old) burst of star formation, although model uncertainties do not allow us to completely discard continuous star formation or a series of bursts over the last few Gyr. In CCGs with emission lines, the gradients in the spectral indices are flat or positive inside the emission-line regions, suggesting the presence of young stars. Outside the emission-line regions, and in cooling flow galaxies without emission lines, gradients are negative and consistent with those measured in CCGs in clusters without cooling hows and giant elliptical galaxies. Index gradients measured exclusively in the emission-line region correlate with hi. Using the same population models we have estimated the radial profiles of the mass transformed into new stars. The derived profiles are remarkably parallel to the expected radial behaviour of the mass deposition rate derived from X-ray observations. Moreover, a large fraction (probably most) of the cooling flow gas accreted into the emission-line region is converted into stars. In the Light of these new data, we discuss the evolutionary sequence suggested by McNamara, in which radio-triggered star formation bursts take place several times during the lifetime of the cooling flow. We conclude that this scenario is consistent with the available observations

Small-worldness favours network inference in synthetic neural networks

R.A.G. and N.R. acknowledge Comisión Sectorial de Investigación Científica (CSIC) research grant 97/2016 (ini_2015_nomina_m2). All authors acknowledge CSIC group grant “CSIC2018 - FID13 - grupo ID 722”.Peer reviewedPublisher PD

Thermal properties of vortices on curved surfaces

We use Monte Carlo simulations to study the finite temperature behavior of vortices in the XY model for tangent vector order on curved backgrounds. Contrary to naive expectations, we show that the underlying geometry does not affect the proliferation of vortices with temperature respect to what is observed on a flat surface. Long-range order in these systems is analyzed by using two-point correlation functions. As expected, in the case of slightly curved substrates these correlations behave similarly to the plane. However, for high curvatures, the presence of geometry-induced unbounded vortices at low temperatures produces the rapid decay of correlations and an apparent lack of long-range order. Our results shed light on the finite-temperature physics of soft-matter systems and anisotropic magnets deposited on curved substrates.Fil: Leopoldo R. Gómez. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Física del Sur. Universidad Nacional del Sur. Departamento de Física. Instituto de Física del Sur; ArgentinaFil: García, Nicolás A.. Institut Laue Langevin; FranciaFil: Vega, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Física del Sur. Universidad Nacional del Sur. Departamento de Física. Instituto de Física del Sur; ArgentinaFil: Lorenzana, José. Università degli studi di Roma "La Sapienza"; Itali