Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning.

Cardiometabolic diseases are an increasing global health burden. While socioeconomic, environmental, behavioural, and genetic risk factors have been identified, a better understanding of the underlying mechanisms is required to develop more effective interventions. Magnetic resonance imaging (MRI) has been used to assess organ health, but biobank-scale studies are still in their infancy. Using over 38,000 abdominal MRI scans in the UK Biobank, we used deep learning to quantify volume, fat, and iron in seven organs and tissues, and demonstrate that imaging-derived phenotypes reflect health status. We show that these traits have a substantial heritable component (8-44%) and identify 93 independent genome-wide significant associations, including four associations with liver traits that have not previously been reported. Our work demonstrates the tractability of deep learning to systematically quantify health parameters from high-throughput MRI across a range of organs and tissues, and use the largest-ever study of its kind to generate new insights into the genetic architecture of these traits

Case studies for Social Transformation through Occupation

Sarah Kantartzis - ORCID 0000-0001-5191-015X https://orcid.org/0000-0001-5191-015XWith the financial support of the European Network of Occupational Therapy in Higher Education (ENOTHE) as part of the work of the project group Social Transformation through Occupation

Channel culture and economic performance in a competitive environment : Toyota and Nissan

From Crossref via Jisc Publications Router

“Making change by shared doing”: An examination of occupation in processes of social transformation in five case studies

From Crossref journal articles via Jisc Publications RouterSarah Kantartzis - ORCID: 0000-0001-5191-015X https://orcid.org/0000-0001-5191-015XBackground: As social and health inequalities deepen around the world, scholarship in occupational therapy and occupational science has increasingly emphasised the role of occupation as a powerful tool in transformative processes. Objective: To explore how opportunities for everyday doing together may contribute to processes of social transformation by identifying ways occupation is being taken up in socially-transformative practice. Material and Methods: A generic descriptive qualitative case study design was utilized in order to describe current practice examples and identify ways occupation was being taken up in five initiatives working towards social transformation located in Canada, Germany, South Africa and the United Kingdom. Results: Focusing on the positioning of occupation within the initiatives, three themes were developed: The intentionality of the process, the nature of occupation within the initiatives, and the role of occupation within the processes of social transformation. Conclusions and Significance: Providing examples of agency on the micro level and of engagement with socioeconomic, political and cultural power structures at the societal level, this analysis raises important considerations in addressing how occupational therapy practice can move in socially responsive and transformative directions.The authors would like to thank the European Network of Occupational Therapy in Higher Education (ENOTHE) for financial support of this research.aheadofprintaheadofprin

Improved science-based transformation pathways for the development of safe and sustainable plastics

Projected plastic production volumes are rising, as is societal and political attention to plastic pollution and possible health impacts. In line with ambitions for climate mitigation and the circular economy, various national and international policies and action plans address the reduction of impacts of plastics. Quantitative scenario analyses show that even if current ambitious targets to reduce plastics are achieved, plastics will remain a source of millions of tons of environmental pollution annually. To achieve a sustainable transformation of the global plastics economy, 'extraordinary effort' and 'coordinated global action' beyond current ambitions are needed. While mapping knowledge gaps for the effects of micro and nano plastics (MNP) is crucial, mapping alone is not enough to achieve the needed transition. In this communication, we propose a scope for the exploration of societal transformation pathways to safe and sustainable plastics. To see which efforts are needed globally we need to advance in the following three areas: (i) embedding risk assessment methodologies in wider cost-benefit and life cycle analyses; (ii) using safe-and-sustainable design strategies that include alternative solutions and look at multiple life cycles, and (iii) reflecting on the societal transformation pathways with stakeholders by using co-created quantitative models. We believe that these practices are crucial in the coming decade to realise the extraordinary effort of defining safe and sustainable plastics

Improved science-based transformation pathways for the development of safe and sustainable plastics.

Projected plastic production volumes are rising, as is societal and political attention to plastic pollution and possible health impacts. In line with ambitions for climate mitigation and the circular economy, various national and international policies and action plans address the reduction of impacts of plastics. Quantitative scenario analyses show that even if current ambitious targets to reduce plastics are achieved, plastics will remain a source of millions of tons of environmental pollution annually. To achieve a sustainable transformation of the global plastics economy, 'extraordinary effort' and 'coordinated global action' beyond current ambitions are needed. While mapping knowledge gaps for the effects of micro and nano plastics (MNP) is crucial, mapping alone is not enough to achieve the needed transition. In this communication, we propose a scope for the exploration of societal transformation pathways to safe and sustainable plastics. To see which efforts are needed globally we need to advance in the following three areas: (i) embedding risk assessment methodologies in wider cost-benefit and life cycle analyses; (ii) using safe-and-sustainable design strategies that include alternative solutions and look at multiple life cycles, and (iii) reflecting on the societal transformation pathways with stakeholders by using co-created quantitative models. We believe that these practices are crucial in the coming decade to realise the extraordinary effort of defining safe and sustainable plastics