Substituted phenylarsonic acids; structures and spectroscopy

Full NMR and ESI-MS spectra, and differential scanning calorimeter data are presented for 15 substituted phenylarsonic acids, including two new fluoro-substituted examples. X-ray crystal structure determinations of five examples (phenylarsonic acid and the 4-fluoro-, 4-fluoro-3-nitro-, 3-amino-4-hydroxy- and 3-amino-4-methoxy-substituted derivatives) were determined and the H-bonding crystal-packing patterns analysed

Hydrodynamic origin of diffusion in nanopores

We study the transport of a subcritical Lennard-Jones fluid in a cylindrical nanopore, using a combination of equilibrium and nonequilibrium as well as dual control volume grand canonical molecular dynamics methods. We show that all three techniques yield the same value of the transport coefficient for diffusely reflecting pore walls, even in the presence of viscous transport. We also demonstrate that the classical Knudsen mechanism is not manifested, and that a combination of viscous flow and momentum exchange at the pore wall governs the transport over a wide range of densities

Effects of a multi-component exercise program and calcium–vitamin-D3-fortified milk on bone mineral density in older men : a randomised controlled trial

Summary We examined the independent and combined effects of a multi-component exercise program and calcium&ndash;vitamin-D3-fortified milk on bone mineral density (BMD) in older men. Exercise resulted in a 1.8% net gain in femoral neck BMD, but additional calcium&ndash;vitamin D3 did not enhance the response in this group of older well-nourished men.Introduction This 12-month randomised controlled trial assessed whether calcium&ndash;vitamin-D3-fortified milk could enhance the effects of a multi-component exercise program on BMD in older men.Methods Men (n&thinsp; =&thinsp;180) aged 50&ndash;79 years were randomised into: (1) exercise + fortified milk; (2) exercise; (3) fortified milk; or (4) controls. Exercise consisted of high intensity progressive resistance training with weight-bearing impact exercise. Men assigned to fortified milk consumed 400 mL/day of low fat milk providing an additional 1,000 mg/day calcium and 800 IU/day vitamin D3. Femoral neck (FN), total hip, lumbar spine and trochanter BMD and body composition (DXA), muscle strength 25-hydroxyvitamin D and parathyroid hormone (PTH) were assessed.Results There were no exercise-by-fortified milk interactions at any skeletal site. Exercise resulted in a 1.8% net gain in FN BMD relative to no-exercise (p&thinsp;&lt;&thinsp;0.001); lean mass (0.6 kg, p&thinsp;&lt;&thinsp;0.05) and muscle strength (20&ndash;52%, p&thinsp;&lt;&thinsp;0.001) also increased in response to exercise. For lumbar spine BMD, there was a net 1.4&ndash;1.5% increase in all treatment groups relative to controls (all p&thinsp;&lt;&thinsp;0.01). There were no main effects of fortified milk at any skeletal site.Conclusion A multi-component community-based exercise program was effective for increasing FN BMD in older men, but additional calcium&ndash;vitamin D3 did not enhance the osteogenic response.<br /

Direct and Heterodyne Detection of Microwaves in a Metallic Single Wall Carbon Nanotube

This letter reports measurements of microwave (up to 4.5 GHz) detection in metallic single-walled carbon nanotubes. The measured voltage responsivity was found to be 114 V/W at 77K. We also demonstrated heterodyne detection at 1 GHz. The detection mechanism can be explained based on standard microwave detector theory and the nonlinearity of the DC IV-curve. We discuss the possible causes of this nonlinearity. While the frequency response is limited by circuit parasitics in this measurement, we discuss evidence that indicates that the effect is much faster and that applications of carbon nanotubes as terahertz detectors are feasible

Electroweak Theory Without Higgs Bosons

A perturbative SU(2)_L X U(1)_Y electroweak theory containing W, Z, photon, ghost, lepton and quark fields, but no Higgs or other fields, gives masses to W, Z and the non-neutrino fermions by means of an unconventional choice for the unperturbed Lagrangian and a novel method of renormalisation. The renormalisation extends to all orders. The masses emerge on renormalisation to one loop. To one loop the neutrinos are massless, the A -> Z transition drops out of the theory, the d quark is unstable and S-matrix elements are independent of the gauge parameter xi.Comment: 27 pages, LaTex, no figures; revised for publication; accepted by Int. J. Mod. Phys. A; includes biographical note on A. F. Nicholso

"It's going to be hard you know…" Teachers' perceived role in widening access to medicine.

Medical schools worldwide undertake widening access (WA) initiatives (e.g. pipeline, outreach and academic enrichment programmes) to support pupils from high schools which do not traditionally send high numbers of applicants to medicine. UK literature indicates that pupils in these schools feel that their teachers are ill-equipped, cautious or even discouraging towards their aspiration and/or application to medicine. This study aimed to explore teachers' perspectives and practices to include their voice in discussions and consider how medical schools might best engage with them to facilitate WA. Interviews were conducted with high school teachers in three UK regions, working in schools targeted by WA initiatives. Data were analysed thematically using template analysis, using a largely data-driven approach. Findings showed that although medicine was largely seen as a prestigious and worthwhile career, teachers held reservations about advocating this above other choices. Teachers saw it as their role to encourage pupils to educate themselves about medicine, but to ultimately allow pupils to make their own decisions. Their attitudes were influenced by material constraints in their schools, and the perception of daunting, long and emotionally difficult admissions requirements, with low chances of success. Medical schools may wish to work with teachers to understand their hesitations and help them develop the mindset required to advocate a challenging and unfamiliar career, emphasising that this encouragement can further the shared goal of empowering and preparing pupils to feel capable of choosing medicine. Reciprocally, medical schools should ensure pupils have fair opportunities for access, should they choose to apply

Modeling mixture transport at the nanoscale: Departure from existing paradigms

We present a novel theory of mixture transport in nanopores, which represents wall effects via a species-specific friction coefficient determined by its low density diffusion coefficient. Onsager coefficients from the theory are in good agreement with those from molecular dynamics simulation, when the nonuniformity of the density distribution is included. It is found that the commonly used assumption of a uniform density in the momentum balance is in serious error, as is also the traditional use of a mixture center of mass based frame of reference

Non-additive properties of finite 1D Ising chains with long-range interactions

We study the statistical properties of Ising spin chains with finite (although arbitrary large) range of interaction between the elements. We examine mesoscopic subsystems (fragments of an Ising chain) with the lengths comparable with the interaction range. The equivalence of the Ising chains and the multi-step Markov sequences is used for calculating different non-additive statistical quantities of a chain and its fragments. In particular, we study the variance of fluctuating magnetization of fragments, magnetization of the chain in the external magnetic field, etc. Asymptotical expressions for the non-additive energy and entropy of the mesoscopic fragments are derived in the limiting cases of weak and strong interactions.Comment: 20 pages, 4 figure