Decision Model for Additive versus Conventional Construction in Remote Locations

Additive construction is a potential game changing innovative alternative to conventional methods with regards to structural integrity, timeliness, and waste reduction, especially in remote locations. While there have been numerous studies into the material science, additive construction will not be a viable alternative until a cost analysis is performed. This paper details the cost elements for both methods. Breaking down the key variables of material, logistics and transportation, and labor costs garner a better understanding of the cost difference between the two construction methods

Outcomes of Shoulder Arthroplasty Performed for Postinfectious Arthritis.

Background: The purpose of this study was to evaluate the functional outcomes, infection rate, and complications associated with shoulder arthroplasty for sequelae of prior septic arthritis. Methods: This is a retrospective cohort study of 17 patients who underwent shoulder arthroplasty for sequelae of septic arthritis. Patients were analyzed for patient-reported outcomes, complications, and reoperations. Results: The 17 patients in this cohort were an average age of 65.4 ± 12.2 years old, were 58.8% male, and had an average body mass index of 27.9 ± 4.1 kg/m Conclusions: Shoulder arthroplasty after septic arthritis had inconsistent functional outcomes and high complication rates but no reinfection

Weather-related Construction Delays in a Changing Climate: A Systematic State-of-the-art Review

Adverse weather delays forty-five percent of construction projects worldwide, costing project owners and contractors billions of dollars in additional expenses and lost revenue each year. Additionally, changes in climate are expected to increase the frequency and intensity of weather conditions that cause these construction delays. Researchers have investigated the effect of weather on several aspects of construction. Still, no previous study comprehensively (1) identifies and quantifies the risks weather imposes on construction projects, (2) categorizes modeling and simulation approaches developed, and (3) summarizes mitigation strategies and adaptation techniques to provide best management practices for the construction industry. This paper accomplishes these goals through a systematic state-of-the-art review of 3207 articles published between 1972 and October 2020. This review identified extreme temperatures, precipitation, and high winds as the most impactful weather conditions on construction. Despite the prevalence of climate-focused delay studies, existing research fails to account for future climate in the modeling and identification of delay mitigation strategies. Accordingly, planners and project managers can use this research to identify weather-vulnerable activities, account for changing climate in projects, and build administrative or organizational capacity to assist in mitigating weather delays in construction. The cumulative contribution of this review will enable sustainable construction scheduling that is robust to a changing climate

Pre-supernova alert system for Super-Kamiokande

In 2020, the Super-Kamiokande (SK) experiment moved to a new stage (SK-Gd) in which gadolinium (Gd) sulfate octahydrate was added to the water in the detector, enhancing the efficiency to detect thermal neutrons and consequently improving the sensitivity to low energy electron anti-neutrinos from inverse beta decay (IBD) interactions. SK-Gd has the potential to provide early alerts of incipient core-collapse supernovae through detection of electron anti-neutrinos from thermal and nuclear processes responsible for the cooling of massive stars before the gravitational collapse of their cores. These pre-supernova neutrinos emitted during the silicon burning phase can exceed the energy threshold for IBD reactions. We present the sensitivity of SK-Gd to pre-supernova stars and the techniques used for the development of a pre-supernova alarm based on the detection of these neutrinos in SK, as well as prospects for future SK-Gd phases with higher concentrations of Gd. For the current SK-Gd phase, high-confidence alerts for Betelgeuse could be issued up to 9 hr in advance of the core collapse itself

The Cutaneous Microbiome and Wounds: New Molecular Targets to Promote Wound Healing

The ecological community of microorganisms in/on humans, termed the microbiome, is vital for sustaining homeostasis. While culture-independent techniques have revealed the role of the gut microbiome in human health and disease, the role of the cutaneous microbiome in wound healing is less defined. Skin commensals are essential in the maintenance of the epithelial barrier function, regulation of the host immune system, and protection from invading pathogenic microorganisms. In this review, we summarize the literature derived from pre-clinical and clinical studies on how changes in the microbiome of various acute and chronic skin wounds impact wound healing tissue regeneration. Furthermore, we review the mechanistic insights garnered from model wound healing systems. Finally, in the face of growing concern about antibiotic-resistance, we will discuss alternative strategies for the treatment of infected wounds to improve wound healing and outcomes. Taken together, it has become apparent that commensals, symbionts, and pathogens on human skin have an intimate role in the inflammatory response that highlights several potential strategies to treat infected, non-healing wounds. Despite these promising results, there are some contradictory and controversial findings from existing studies and more research is needed to define the role of the human skin microbiome in acute and chronic wound healing