26 research outputs found

    Exchange and interaction in western Aleutian prehistory: the efficacy of geochemical analysis of lithic raw material procurement on Amchitka Island

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    Thesis (M.A.) University of Alaska Fairbanks, 2007There are two main objectives of this thesis; the first is to evaluate the efficacy of geochemical techniques for the identification of lithic raw materials used to make stone tools in the Aleutian Islands. The second objective is to use the data set acquired from the analytical methods to generate hypotheses pertaining to exchange and interaction on Amchitka Island. Looking at Amchitka's geology using x-ray fluorescence will provide the basis for examining the elemental characterization for identification of basalt materials. From this analysis, I compared the elemental concentration of basalt artifacts between six archaeological sites found on Amchitka. Through the use of principal components analysis, the basalt artifacts were chemically matched with those specimens containing similar elemental properties to determine if they derived from the same geologic sources on Amchitka. The generation of hypotheses was directed towards identifying potential basalt sources locations on Amchitka Island and archaeological sites which may be appropriate candidates for further investigations of exchange and interaction.1. Introduction -- 2. Theoretical background -- 3. Aleutian Islands -- 4. Methods -- 5. Archaeological site descriptions -- 6. Statistical analysis -- 7. Archaeological significance of the data -- 8. Discussion and conclusion -- Bibliography -- Appendices

    Red Sea palaeoclimate: stable isotope and element-ratio analysis of marine mollusc shells

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    The southern Red Sea coast is the location of more than 4,200 archaeological shell midden sites. These shell middens preserve archaeological and climatic archives of unprecedented resolution and scale. By using shells from these contexts, it is possible to link past environmental information with episodes of human occupation and resource processing. This chapter summarises current knowledge about the marine gastropod Conomurex fasciatus (Born 1778) and discusses its use in environmental and climatic reconstruction using stable isotope and elemental ratio analysis. It offers a review of the most recent studies of shell midden sites on the Farasan Islands, their regional importance during the mid-Holocene, theories about seasonal use of the coastal landscape, and preliminary results from new methods to acquire large climatic datasets from C. fasciatus shells

    mGluR5 ablation in cortical glutamatergic neurons increases novelty-induced locomotion.

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    The group I metabotropic glutamate receptor 5 (mGluR5) has been implicated in the pathology of various neurological disorders including schizophrenia, ADHD, and autism. mGluR5-dependent synaptic plasticity has been described at a variety of neural connections and its signaling has been implicated in several behaviors. These behaviors include locomotor reactivity to novel environment, sensorimotor gating, anxiety, and cognition. mGluR5 is expressed in glutamatergic neurons, inhibitory neurons, and glia in various brain regions. In this study, we show that deleting mGluR5 expression only in principal cortical neurons leads to defective cannabinoid receptor 1 (CB1R) dependent synaptic plasticity in the prefrontal cortex. These cortical glutamatergic mGluR5 knockout mice exhibit increased novelty-induced locomotion, and their locomotion can be further enhanced by treatment with the psychostimulant methylphenidate. Despite a modest reduction in repetitive behaviors, cortical glutamatergic mGluR5 knockout mice are normal in sensorimotor gating, anxiety, motor balance/learning and fear conditioning behaviors. These results show that mGluR5 signaling in cortical glutamatergic neurons is required for precisely modulating locomotor reactivity to a novel environment but not for sensorimotor gating, anxiety, motor coordination, several forms of learning or social interactions

    Cx-mGlu5 mice exhibit normal sensorimotor gating and a slight reduction in repetitive behaviors.

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    <p>(<b>A,B</b>) Sensorimotor gating was measured by prepulse inhibition (PPI) of the acoustic startle response in Cx-mGlu5 KO mice in C57/129 mixed (<b>A</b>) or in C57BL/6 background (<b>B</b>) and their littermate controls. Summaries of the maximum startle response to a 120 dB white noise sound burst are shown in the left panel. Summaries for the inhibition of the acoustic startle response by either one of three prepulse levels (74, 78 and 82 dB) are shown on the right. (<b>C</b>) Summaries for the number of marbles buried by Cx-mGlu5 KO and control mice in C57BL6 background.</p
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