Cancer Drugs Fund requires further reform.

[First paragraph] The reforms to the Cancer Drugs Fund implemented in July were an excellent opportunity to generate evidence on the effectiveness of new cancer drugs.1 Unlike under the previous arrangements, data on patients’ outcomes will have to be collected for all drugs funded by the scheme. However, the reforms’ stated reliance on “real world” (observational) data will not generate reliable evidence of effectiveness. We propose an alternative model, using timely randomised controlled trials within routinely collected data sources, to establish which drugs are relatively effective. The current arrangement encourages early access to drugs, with high prices but uncertain benefits, whereas our proposal will provide high quality evidence for future decisions and therefore larger gains in population health

Five Stages of the Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy (STAMPEDE) trial

IDMC  = Independent Data Monitoring Committee; FFS  = failure-free survival; HR  = hazard ratio, where 0 ≤ d ≤ c ≤ b ≤ a ≤ 5.<p><b>Copyright information:</b></p><p>Taken from "Speeding up the Evaluation of New Agents in Cancer"</p><p></p><p>JNCI Journal of the National Cancer Institute 2008;100(17):1204-1214.</p><p>Published online 3 Sep 2008</p><p>PMCID:PMC2528020.</p><p></p

Stopping guidelines on the hazard ratio scale for the Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy (STAMPEDE) trial

CI = confidence interval; HR = hazard ratio; Stop = stopping of accrual (rather than termination of follow up).<p><b>Copyright information:</b></p><p>Taken from "Speeding up the Evaluation of New Agents in Cancer"</p><p></p><p>JNCI Journal of the National Cancer Institute 2008;100(17):1204-1214.</p><p>Published online 3 Sep 2008</p><p>PMCID:PMC2528020.</p><p></p

Additional file 2: Table S1. of UroMark—a urinary biomarker assay for the detection of bladder cancer

RainDance target primers. (XLSX 13 kb

Additional file 4: Table S3. of UroMark—a urinary biomarker assay for the detection of bladder cancer

RainDance custom sequencing primers. (XLSX 8 kb

Additional file 5: Figure S1. of UroMark—a urinary biomarker assay for the detection of bladder cancer

A) MDS plot of 150 UroMark loci panel, tumour = red, normal = blue, B) ROC for cross validation accuracy of 150 loci UroMark assay. Figure S2. A) MDS plot of 150 UroMark loci panel in 179 sample validation cohort, High grade = red, low grade = green, normal = blue, B) ROC for cross validation accuracy of 150 loci UroMark assay in the 179 sample validation cohort. Figure S3. A) Boxplots of methylation values for top 10 performing markers in the primary tissue training cohort. B) Boxplots of methylation values for top 10 performing markers in the in urine samples validation cohorts (normal – confirmed no tumour, tumour - histological confirmation of TCC). Figure S4. A) Boxplots of methylation values for top 10 performing markers in the primary tissue training cohort. B) Boxplots of methylation values for top 10 performing markers in the in urine samples validation cohorts (normal – confirmed no tumour, tumour histological confirmation of TCC). (PDF 164 kb