The phenotype and in-vitro culture characteristics of human multiple myeloma cells

Imperial Users onl

Assessing the stability of thematic and taxonomic preferences across explicit and implicit measures

Assessments of similarity between objects has shown to draw upon both taxonomic and thematic properties. While cross-task preferences have been demonstrated (Mirman & Graziano, 2012), the current experiment aimed to examine the reliability of such preferences across an extended range of explicit and implicit measures of similarity. In a within-subjects design, 50 participants completed three established measures assessing preferences for taxonomic or thematic relations; a free sort task, a triad task and the Visual World Paradigm, with a further implicit measure developed based upon the single category Implicit Association Task. Preferences were calculated on the basis of choices made on the sorting and triad task, competitor viewing time on the VWP, and response time on the IAT. Across all measures, consistent preferences were not found. Furthermore, no significant correlations were found between the magnitude of preferences for the four measures including no correlations between the two explicit or the two implicit measures. In contrast to previous research demonstrating reliable cross-task preferences, performance on the tasks used here argue against stable individual differences in taxonomic and thematic processing and suggest that, for most people, the use of each processing pathway is flexible and determined by both context and goals.Non peer reviewe

The Development of Academic Dress in the University of Warwick

The University of Warwick received its royal charter on 8 March 1965, one of a number of new universities established in the 1960s in response to the Robbins report on higher education, which recommended an immediate expansion in the university sector in the UK. Warwick was one of the first wave of such universities—later dubbed ‘plate-glass universities’—which included Sussex (1961), East Anglia (1962), York (1963), Essex (1964), Lancaster (1964) and Kent (1965). The main proposed site for the new University was an area of farm land lying between Kenilworth Road on the south-east and Westwood Heath Road and the existing Teacher Training College on the north-east. The City of Coventry donated a 234-acre portion of land (bordered on the south-west by Gibbet Hill Road) to the project in March 1960; this was augmented by a further 183 acres (on the other side of Gibbet Hill Road) donated by the County of Warwickshire. [Excerpt]

In Vitro And In Vivo Measurments Of Serotonin For Ecological And Mental Health Via Fast Scan Cyclic Voltammetry

Fast Scan Cyclic Voltammetry has been proven to be a highly valuable technique in analysis and detection of neurotransmitters. With this technique, two novel applications are being explored to protect natural water sources as well as furthering the efficacy of antidepressants. Despite setbacks, promising data has been collected to further understand the mechanisms involved in the phototactic response observed in Daphnia Magna. Electrochemical modification of carbon fiber microelectrodes has proven to be inefficient as a means to effectively differentiate between serotonin and its metabolite. As such, this unsuccessful attempt has further narrowed down the list of candidates to electrochemically differentiate between 5-HT and 5-HIAA

The Spectacle of Neoclassical Economics: The Chad-Cameroon Petroleum Development Project and Exploitation in the Niger Delta and the Chad Basin

In recent years, neoclassical economic literature has undergone a fundamental change of emphasis, from orthodox neoclassical to neoinstitutional theory. World Bank research and high-level policy departments have reflected this change by shifting from development as ‘structural adjustment’ to development as ‘governance’. I engage the case of the Chad-Cameroon Petroleum Development Project (CCPDP) to argue that the neoclassical economic shift is a spectacle or exhibit, irrelevant in important ways to exploitation “on the ground.” Contrary to neoclassical economics and World Bank development rationales, the CCPDP is a hyper-documented project with a hyperrestricted scope, typical of commodity exploitation in Central Africa and elsewhere. I use the case of key commodity exploitation over the last 600 years in Nigeria to show parallels with the CCPDP. First, I show the use of exhibits, spectacular violence and quotidian control in exploitation of Nigeria from slave trade with dynastic canoe houses through petroleum production at the time of nominal independence. Second, Watts’ examination of petroleum exploitation through the lens of the oil complex and the petrostate provides detailed analysis of the “ungovernable governmentality” that characterizes such exploitation in Nigeria and in the larger “oil complex.” Thirdly, I examine writing on CSR as well as evidence that political instability can be a competitive advantage. This undercuts the important neoclassical economic development notion that business simply “does business” while government and civil society are responsible for human welfare. In my conclusion I offer provisional areas where the project points to further research. These include the importance of interdisciplinary regional focus on the Chad basin and the Gulf of Guinea, including the value of business literature; ways of effectively examining social movement pressure and corporate response; and the implications of designing a project around governmentality and relational power for studies of hegemony, power and development

Adaptive Finite Element Solution of 1D European Option Pricing Problems

We present a piecewise Hermite cubic adaptive finite element method for solving a generalised European Black-Scholes problem to guaranteed accuracy. Specifically, we prove a residual-based a posteriori error bound in the $L^{2}(\Omega)$-norm, at contract issue, for a continuous Galerkin approximation to the solution using Galerkin orthogonality and weighted strong stability of an associated dual problem. We use this bound to construct an adaptive algorithm to generate a space-time discretisation which ensures that the error norm is less than a given tolerance. We demonstrate the speed and accuracy of our method through example pricings

Provision of Fluoride Varnish Treatment by Medical and Dental Care Providers: Variation by Race/Ethnicity and Levels of Urban Influence

Objective: In 2004, Wisconsin Medicaid policy changed to allow medical care providers to be reimbursed for fluoride varnish treatment (FVT) to children\u27s teeth to improve access and utilization. To date, no study has been published on whether geographic and racial/ethnic variation in the provision of FVT in response to this policy change exists. This study\u27s objective is to examine the association of rates of FVT for children enrolled in Wisconsin Medicaid with race/ethnicity, urban influence codes (UIC), and dental health professional shortage area (DHPSA) designation based on county of residence. Methods: A retrospective, pre–post design was used based on FVT claims for children in the Wisconsin Medicaid program from 2002 to 2006. Poisson regression models were used to evaluate the association of rates of FVT claims with race/ethnicity, UIC, and DHPSA designation. Results: The rate of FVT claims varied by resident county-type according to UIC and DHPSA designation, age, and race/ethnicity. Post-policy, the largest increases were observed for Native Americans residing in non-DHPSA counties, enrollees living in rural counties, and for Hispanics living in partial and entire DHPSA counties. African-Americans residing in partial DHPSA and metropolitan counties displayed the lowest rates of FVT claims. Conclusions: Overall access and utilization of FVT increased, but substantial racial/ethnic and geographic variation in the provision of FVT for children enrolled in Wisconsin Medicaid was observed. Future policies should incorporate measures that will specifically address the racial and geographic variations identified in this study

Current trends in glioblastoma multiforme treatment: radiation therapy and immune checkpoint inhibitors.

Glioblastoma multiforme (GBM) is the most common primary brain cancer. Even with aggressive combination therapy, the median life expectancy for patients with GBM remains approximately 14 months. In order to improve the outcomes of patients with GBM, the development of newer treatments is critical. The concept of using the immune system as a therapeutic option has been suggested for several decades; by harnessing the body's adaptive immune mechanisms, immunotherapy could provide a durable and targeted treatment against cancer. However, many cancers, including GBM, have developed mechanisms that protect tumor cells from being recognized and eliminated by the immune system. For new immunotherapeutic regimens to be successful, overcoming immunosuppression via immune checkpoint signaling should be taken into consideration