CRS Issue Briefs

The United States recognized the independence of all the former Soviet republics by the end of 1991, including the South Caucasus states of Armenia, Azerbaijan, and Georgia. The United States has fostered these states' ties with the West in part to end the dependence of these states on Russia for trade, security, and other relations. The FREEDOM Support Act of 1992 provides authorization for assistance to the Eurasian states for humanitarian needs, democratization, and other purposes. In the aftermath of the September 11, 2001, terrorist attacks on the United States, the Administration appealed for a national security waiver of the prohibition on aid to Azerbaijan, in consideration of Azerbaijan's assistance to the international coalition to combat terrorism. Azerbaijani and Georgian troops participate in stabilization efforts in Afghanistan and Iraq, and Armenian personnel serve in Iraq

CRS Issue Briefs

The United States recognized the independence of all the former Soviet republics by the end of 1991, including the South Caucasus states of Armenia, Azerbaijan, and Georgia. The United States has fostered these states' ties with the West in part to end the dependence of these states on Russia for trade, security, and other relations. The FREEDOM Support Act of 1992 provides authorization for assistance to the Eurasian states for humanitarian needs, democratization, and other purposes. In the aftermath of the September 11, 2001, terrorist attacks on the United States, the Administration appealed for a national security waiver of the prohibition on aid to Azerbaijan, in consideration of Azerbaijan's assistance to the international coalition to combat terrorism. Azerbaijani and Georgian troops participate in stabilization efforts in Afghanistan and Iraq, and Armenian personnel serve in Iraq

CRS Issue Briefs

The United States recognized the independence of all the former Soviet republics by the end of 1991, including the South Caucasus states of Armenia, Azerbaijan, and Georgia. The United States has fostered these states' ties with the West in part to end the dependence of these states on Russia for trade, security, and other relations. The FREEDOM Support Act of 1992 provides authorization for assistance to the Eurasian states for humanitarian needs, democratization, and other purposes. In the aftermath of the September 11, 2001, terrorist attacks on the United States, the Administration appealed for a national security waiver of the prohibition on aid to Azerbaijan, in consideration of Azerbaijan's assistance to the international coalition to combat terrorism. Azerbaijani and Georgian troops participate in stabilization efforts in Afghanistan and Iraq, and Armenian personnel serve in Iraq

The Cut & Enhance method : selecting clusters of galaxies from the SDSS commissioning data

We describe an automated method, the Cut & Enhance method (CE) for detecting clusters of galaxies in multi-color optical imaging surveys. This method uses simple color cuts, combined with a density enhancement algorithm, to up-weight pairs of galaxies that are close in both angular separation and color. The method is semi-parametric since it uses minimal assumptions about cluster properties in order to minimize possible biases. No assumptions are made about the shape of clusters, their radial profile or their luminosity function. The method is successful in finding systems ranging from poor to rich clusters of galaxies, of both regular and irregular shape. We determine the selection function of the CE method via extensive Monte Carlo simulations which use both the real, observed background of galaxies and a randomized background of galaxies. We use position shuffled and color shuffled data to perform the false positive test. We have also visually checked all the clusters detected by the CE method. We apply the CE method to the 350 deg^2 of the SDSS (Sloan Digital Sky Survey) commissioning data and construct a SDSS CE galaxy cluster catalog with an estimated redshift and richness for each cluster. The CE method is compared with other cluster selection methods used on SDSS data such as the Matched Filter (Postman et al. 1996, Kim et al. 2001), maxBCG technique (Annis et al. 2001) and Voronoi Tessellation (Kim et al. 2001). The CE method can be adopted for cluster selection in any multi-color imaging surveys.Comment: 62 pages, 32 figures, Accepted for publication in the Astronomical Journal, "the CE galaxy cluster catalog can be downloaded from, http://astrophysics.phys.cmu.edu/~tomo/ce/

Pharmacodynamic Activity of Ceftobiprole Compared with Vancomycin versus Methicillin-Resistant \u3cem\u3eStaphylococcus aureus\u3c/em\u3e (MRSA), Vancomycin-Intermediate \u3cem\u3eStaphylococcus aureus\u3c/em\u3e (VISA) and Vancomycin-Resistant \u3cem\u3eStaphylococcus aureus\u3c/em\u3e (VRSA) Using an In Vitro Model

Background This study compared the pharmacodynamics of ceftobiprole and vancomycin against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA) using an in vitro model. Methods Two methicillin-susceptible S. aureus (MSSA), two community-associated (CA)-MRSA, one healthcare-associated (HA)-MRSA, three VISA and two VRSA were studied. The pharmacodynamic model was inoculated with a concentration of 1 × 106 cfu/mL and ceftobiprole dosed every 8 h (at 0, 8 and 16 h) to simulate the fCmax and t1/2 obtained after 500 mg intravenous (iv) every 8 h dosing (fCmax, 30 mg/L; t1/2, 3.5 h). Vancomycin was dosed every 12 h (at 0 and 12 h) to simulate fCmax and t1/2 obtained after 1 g iv every 12 h dosing (fCmax, 20 mg/L; t1/2, 8 h). Samples were collected over 24 h to assess viable growth. Results Ceftobiprole T \u3e MIC of ≥100% (ceftobiprole MICs, ≤2 mg/L) was bactericidal (≥3 log10 killing) against MSSA, CA-MRSA, HA-MRSA, VISA and VRSA at 16 and 24 h. Vancomycin fAUC24/MIC of 340 (vancomycin MIC, 1 mg/L for MSSA and MRSA) resulted in a 1.8–2.6 log10 reduction in colony count at 24 h. Vancomycin fAUC24/MIC of 85–170 (vancomycin MIC, 2–4 mg/L for VISA) resulted in a 0.4–0.7 log10 reduction at 24 h. Vancomycin fAUC24/MIC of 5.3 (vancomycin MIC, 64 mg/L for VRSA) resulted in a limited effect. Conclusions Ceftobiprole T \u3e MIC of ≥100% (ceftobiprole MICs, ≤2 mg/L) was bactericidal (≥3 log10 killing) against MSSA, CA-MRSA, HA-MRSA, VISA and VRSA at 16 and 24 h. Vancomycin was bacteriostatic against MSSA, MRSA and VISA, while demonstrating no activity against VRSA

Bunyaviruses and the Type I Interferon System

The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as an emerging threat, details of the virulence mechanisms employed by bunyaviruses are scant. In this article we summarise the information currently available on how these viruses are able to establish infection when confronted with a powerful antiviral interferon system

SDSS-RASS: Next Generation of Cluster-Finding Algorithms

We outline here the next generation of cluster-finding algorithms. We show how advances in Computer Science and Statistics have helped develop robust, fast algorithms for finding clusters of galaxies in large multi-dimensional astronomical databases like the Sloan Digital Sky Survey (SDSS). Specifically, this paper presents four new advances: (1) A new semi-parametric algorithm - nicknamed ``C4'' - for jointly finding clusters of galaxies in the SDSS and ROSAT All-Sky Survey databases; (2) The introduction of the False Discovery Rate into Astronomy; (3) The role of kernel shape in optimizing cluster detection; (4) A new determination of the X-ray Cluster Luminosity Function which has bearing on the existence of a ``deficit'' of high redshift, high luminosity clusters. This research is part of our ``Computational AstroStatistics'' collaboration (see Nichol et al. 2000) and the algorithms and techniques discussed herein will form part of the ``Virtual Observatory'' analysis toolkit.Comment: To appear in Proceedings of MPA/MPE/ESO Conference "Mining the Sky", July 31 - August 4, 2000, Garching, German

Assessment of the Activity of Ceftaroline Against Clinical Isolates of Penicillin-Intermediate and Penicillin-Resistant \u3cem\u3eStreptococcus pneumoniae\u3c/em\u3e with elevated MICs of Ceftaroline Using an In Vitro Pharmacodynamic Model

Objectives This study assessed the pharmacodynamics of ceftaroline against penicillin-intermediate and penicillin-resistant Streptococcus pneumoniae with elevated MICs of ceftaroline using an in vitro pharmacodynamic model. Methods Nine isolates of S. pneumoniae, including one penicillin-susceptible isolate, one penicillin-intermediate isolate and seven penicillin-resistant isolates, were tested. The pharmacodynamic model was inoculated with a concentration of 1 × 106 cfu/mL and ceftaroline was dosed twice daily (at 0 and 12 h) to simulate the fCmax (maximum free concentration in serum) and t1/2 (half-life in serum) obtained after 600 mg intravenous doses every 12 h (fCmax, 16 mg/L; t1/2, 2.6 h). Ceftaroline was compared with ceftriaxone dosed once daily to simulate the fCmax and t1/2 obtained after a 1 g dose (fCmax, 18 mg/L; t1/2, 8.0 h). Samples were collected over 24 h to assess viable growth and possible changes in ceftaroline MICs over time. Results Ceftaroline fT\u3eMIC (time of free serum concentration over the MIC) of 100% (ceftaroline MICs, ≤0.5 mg/L) was bactericidal (≥3 log10 killing) against all isolates at 6 h and completely eradicated all organisms at 12 and 24 h. No bacterial regrowth occurred over the study period and no changes in ceftaroline MICs were observed. Upon ceftriaxone exposure, S. pneumoniae isolates with ceftriaxone MICs of 0.12 and 0.25 mg/L were eradicated, but isolates with ceftriaxone MICs of 1–8 mg/L resulted in initial bacterial reduction at 6 h with organism regrowth at 12 h and no reduction in organism concentration, relative to the starting inoculum, at 24 h. Conclusions Ceftaroline fT\u3eMIC of 100% (ceftaroline MICs, ≤0.5 mg/L) was bactericidal (≥3 log10 killing) and eradicated all S. pneumoniae at 12 and 24 h with no regrowth

Global analysis of neutrino masses, mixings and phases: entering the era of leptonic CP violation searches

We perform a global analysis of neutrino oscillation data, including high-precision measurements of the neutrino mixing angle theta_13 at reactor experiments, which have confirmed previous indications in favor of theta_13>0. Recent data presented at the Neutrino 2012 Conference are also included. We focus on the correlations between theta_13 and the mixing angle theta_23, as well as between theta_13 and the neutrino CP-violation phase delta. We find interesting indications for theta_23< pi/4 and possible hints for delta ~ pi, with no significant difference between normal and inverted mass hierarchy.Comment: Updated version, including recent data released at the Neutrino 2012 Conference. Some references adde