The Bottom-Up EFT: Complete UV Resonances of the SMEFT Operators

The standard model effective field theory (SMEFT) provides systematic parameterization of all possible new physics above the electroweak scale. According to the amplitude-operator correspondence, an effective operator can be decomposed into a linear combination of several j-basis operators, which correspond to local amplitudes carrying certain spin and gauge quantum numbers in a particular scattering channel. Based on the Poincare and gauge symmetries of scattering amplitude, we construct the j-basis using the Casimir method for both the Lorentz and gauge sectors. The quantum numbers of the j-basis operators fix the quantum numbers of any intermediate state in the corresponding amplitudes, such as a UV resonance. This can be re-interpreted as the j-basis/UV correspondence, thus obtaining the j-bases in all partitions of fields for an operator amounts to finding all of its UV origins at tree level, constituting the central part of the bottom-up EFT framework. Applying the j-basis analysis to SMEFT, we obtain a complete list of possible tree-level UV origins of the effective operators at the dimension 5, 6, 7, and all the bosonic operators at the dimension 8.Comment: 123 pages, 19 figures, 34 table

Transcriptomic comparison of the self-pollinated and cross-pollinated flowers of Erigeron breviscapus to analyze candidate self-incompatibility-associated genes

Table S1. Functional annotation of E.breviscapus transcriptome. (XLSX 4281 kb

Cloning and characterization of an S-RNase gene in Camellia sinensis

AbstractSelf-incompatibility (SI) prevents inbreeding depression in angiosperms. Camellia sinensis is an important cash crop, but breeding improvements and genetic studies of the plant are hindered by SI. However, the SI mechanism in C. sinensis remains unclear. In this study, a putative S-RNase gene (KU852488) was cloned from C. sinensis. The full-length cDNA of CsS-RNase is 1121bp, which encodes 238 amino acids. It shares the closest relationship with an S-RNase gene (ADA67883.1), which was cloned from a self-incompatibility Citrus reticulata cultivar ‘Wuzishatangju’. The expression level of CsS-RNase in the styles were 3–259 (‘Fuding Dabaicha’) and 5.6–119 (‘Zhongcha108’) times higher than the other tissues, for example petals, pollen grains, filaments and buds. And its expression rose in self-pollinated styles with 24h earlier than cross-pollinated styles. The genotypes of CsS-RNase in 10 cultivars and one breeding line of C. sinensis were analyzed. Totally, 11 polymorphic amino acid residues were identified. A single nucleotide polymorphism (SNP) marker of CsS-RNase was developed. Finally, the CsS-RNase was mapped onto a reference genetic linkage map of tea plant

PO-014 The effects of HIIT on ROS-AMPK- PGC-1α pathway in skeletal muscle and VO2max of ageing Wistar rats.

Objective To observe the 16 weeks of HIIT intervention on SOD,ROS and its related factors AMPK and oxidation capacity PGC-1α expression and the influence of the VO2max and its change rule in the process of the natural aging rats, To explore the correlation between the expression of ROS, AMPK and PGC-1αand the change of VO2max; Furthermore, it provides a theoretical basis for HIIT to delay the reduction of aerobic capacity in skeletal muscle ageing. Methods 58 male wistar rats(age：32 weeks) were selected and randomly divided into quiet group (C) and HIIT intervention group (H). All rats were fed in the barrier environment. Each group of rats entered the animal laboratory for a week of adaptive feeding and exercise. VO2max was tested and observed every two weeks in each group. Rats of group C don't exercise, group H at a rate of 50%, 70% and 90% VO2max corresponding alternation of 50 min/day, 5 days/week, for 16 weeks of exercise intervention, and according to the VO2max test results the exercise intensity. Both groups of rats in the intervention of 8 weeks, 16 weeks after the end of the 24 hours of materials, stripping rats soleus, SOD and content of ROS was tested by multifunctional enzyme mark, using western blot test the expression of AMPK and PGC-1α. VO2max, SOD, ROS test results and AMPK, PGC-1α, and relative expression data were analyzed using SPSS for one way ANOVA. Results The cardiopulmonary endurance of rats in group C and group H showed a decreasing trend in group C and group H during HIIT intervention, but the decrease trend in group H was slower than that in group C. 2. During 16 weeks aging , SOD expression of group C in the process of rendering first rise after falling, and expressed in 8 weeks SOD content was significantly lower than base value (P < 0.05), 16 weeks group C SOD levels higher than the base state. After 16 weeks of intervention, the expression of SOD in group H was relatively flat in the first 8 weeks, and the trend was in 8-16 weeks, and was significantly lower than 8 weeks in 16 weeks (P < 0.05). 3.The ROS content was significantly higher than basic state in 8 weeks and 16 weeks in the intervention process (P<0.05), and the ROS content was significantly higher than 8 weeks (P<0.05) at 16 weeks. The ROS content of group C and group H was significantly higher than that in the group at 8 weeks (P < 0.05). 4.The AMPK content in group C was significantly lower than that of the basic value (P<0.05), and the AMPK content in group H was significantly higher than that in group C (P<0.05). 5.After the intervention of 16 weeks, the content of PGC-1α in group C and group H showed a decrease trend and significantly lower than the basic value (P<0.05), but the content of group H was significantly higher than that of group C (P<0.05). 6.The changes of AMPK, PGC-1α and cardiopulmonary endurance were the same in all groups during the intervention. Conclusions 1.16 weeks of HIIT can effectively delay the decrease of SOD content in the aging rats, thus inhibiting the accumulation of ROS in the body. 2.16 weeks of HIIT intervention can effectively delay the expression of VO2max and AMPK and PGC-1α in aging rats. 3.16 weeks HIIT may delay the decrease of AMPK-PGC1 protein expression by inhibiting the accumulation of skeletal muscle ROS in the aging rats, thus inhibiting the decrease of VO2max

Downregulation of T-cell cytotoxic marker IL18R1 promotes cancer proliferation and migration and is associated with dismal prognosis and immunity in lung squamous cell carcinoma

Immunotherapy can improve the survival of patients with advanced lung squamous cell carcinoma (LUSC). T cytotoxic cells are one of the main members of the immune microenvironment. Herein, we aimed to identify the roles of T-cell cytotoxic markers interleukin 18 (IL18) receptor 1 (IL18R1) in the LUSC progression using bioinformatics, clinical tissue specimen, and cell experiment. We assessed the association between the IL18R1 expression and immune infiltration and IL18R1-related competing RNA network. The IL18R1 expression was downregulated in the LUSC tissues. The IL18R1 expression downregulation was associated with diagnosis and short overall survival and disease-specific survival, and it was also an independent risk factor for dismal survival time in LUSC. IL18R1-related nomograms predicted the survival time of patients with LUSC. IL18R1 overexpression inhibited the proliferation, migration, and invasion of LUSC cells. The IL18R1 expression was significantly associated with the microenvironment (stromal, immune, and estimate scores), immune cells (such as the T cells, cytotoxic cells, CD8 T cells), and immune cell markers (such as the CD8A, PD-1, and CTLA4) in LUSC. AC091563.1 and RBPMS-AS1 downregulation was positively associated with the IL18R1 expression, negatively associated with the miR-128-3p expression, and associated with short disease-specific survival and progression in LUSC. In conclusion, IL18R1 was significantly downregulated and associated with the prognosis and immune microenvironment. IL18R1 overexpression inhibits the growth and migration of cancer cells in LUSC. Furthermore, AC091563.1 and RBPMS-AS1 might compete with IL18R1 to bind miR-128-3p for participating in LUSC progression. These results showed that IL18R1 is a biomarker for evaluating the prognosis of patients with LUSC

High-performance infrared photodetectors based on InAs/InAsSb/AlAsSb superlattice for 3.5 µm cutoff wavelength spectra

High-performance infrared p-i-n photodetectors based on InAs/InAsSb/AlAsSb superlattices on GaSb substrate have been demonstrated at 300K. These photodetectors exhibit 50% and 100% cut-off wavelength of ∼3.2 µm and ∼3.5 µm, respectively. Under -130 mV bias voltage, the device exhibits a peak responsivity of 0.56 A/W, corresponding to a quantum efficiency (QE) of 28%. The dark current density at 0 mV and -130 mV bias voltage are 8.17 × 10−2 A/cm2 and 5.02 × 10−1 A/cm2, respectively. The device exhibits a saturated dark current shot noise limited specific detectivity (D*) of 3.43 × 109 cm·Hz1/2/W (at a peak responsivity of 2.5 µm) under -130 mV of applied bias

Overexpression of specific CD44 isoforms is associated with aggressive cell features in acquired endocrine resistance

While endocrine therapy is the mainstay of ER+ breast cancer, the clinical effectiveness of these agents is limited by the phenomenon of acquired resistance that is associated with disease relapse and poor prognosis. Our previous studies revealed that acquired resistance is accompanied by a gain in cellular invasion and migration and also that CD44 family proteins are overexpressed in the resistant phenotype. Given the association of CD44 with tumor progression, we hypothesized that its overexpression may act to promote the aggressive behavior of endocrine-resistant breast cancers. Here, we have investigated further the role of two specific CD44 isoforms, CD44v3 and CD44v6, in the endocrine-resistant phenotype. Our data revealed that overexpression of CD44v6, but not CD44v3, in endocrine-sensitive MCF-7 cells resulted in a gain in EGFR signaling, enhanced their endogenous invasive capacity, and attenuated their response to endocrine treatment. Suppression of CD44v6 in endocrine-resistant cell models was associated with a reduction in their invasive capacity. Our data suggest that upregulation of CD44v6 in acquired resistant breast cancer may contribute to a gain in the aggressive phenotype of these cells and loss of endocrine response through transactivation of the EGFR pathway. Future therapeutic targeting of CD44v6 may prove to be an effective strategy alongside EGFR-targeted agents in delaying/preventing acquired resistance in breast cancer

Acylphloroglucinols with acetylcholinesterase inhibitory effects from the fruits of Eucalyptus robusta

Eleven new acylphloroglucinols, including six new formylated phloroglucinol-monoterpene meroterpenoids, eucalyprobusals A-F (1-6), one monomeric acylphloroglucinol, eucalyprobusone B (7), and four dimeric acylphloroglucinols, eucalyprobusones C-F (8-11) were purified from the fruits of Eucalyptus robusta. The establishment of the structures of 1-11 was achieved by a combination of NMR and HRESIMS data analyses, electron circular dichroism (ECD), and single-crystal X-ray diffraction. Compounds 6, 8, and an inseparable mixture of 10 and 11 were found to be potent AChE inhibitors with IC50 values of 3.22 ± 0.36, 3.82 ± 0.22, and 2.55 ± 0.28 μΜ, respectively. Possible interaction sites of 6, 8, 10, and 11 with AChE were investigated by means of molecular docking studies, and the results revealed that AChE residues Asn87, Ser125, Thr83, Tyr133, Tyr124, Tyr337, and Tyr341 played crucial roles in the observed activity of the aforementioned compounds.Accepted manuscrip