Emergent phases in a compass chain with multisite interactions

We study a dimerised spin chain with biaxial magnetic interacting ions in the presence of an externally induced three-site interactions out of equilibrium. In the general case, the three-site interactions play a role in renormalizing the effective uniform magnetic field. We find that the existence of zero-energy Majorana modes is intricately related to the sign of Pfaffian of the Bogoliubov-de Gennes Hamiltonian and the relevant $Z_2$ topological invariant. In contrast, we show that an exotic spin liquid phase can emerge in the compass limit through a Berezinskii-Kosterlitz-Thouless (BKT) quantum phase transition. Such a BKT transition is characterized by a large dynamic exponent $z=4$, and the spin-liquid phase is robust under a uniform magnetic field. We find the relative entropy and the quantum discord can signal the BKT transitions. We also uncover a few differences in deriving the correlation functions for the systems with broken reflection symmetry.Comment: 12 pages, 10 figure

Astrodynamical Space Test of Relativity using Optical Devices I (ASTROD I) - A class-M fundamental physics mission proposal for Cosmic Vision 2015-2025: 2010 Update

This paper on ASTROD I is based on our 2010 proposal submitted for the ESA call for class-M mission proposals, and is a sequel and an update to our previous paper [Experimental Astronomy 23 (2009) 491-527; designated as Paper I] which was based on our last proposal submitted for the 2007 ESA call. In this paper, we present our orbit selection with one Venus swing-by together with orbit simulation. In Paper I, our orbit choice is with two Venus swing-bys. The present choice takes shorter time (about 250 days) to reach the opposite side of the Sun. We also present a preliminary design of the optical bench, and elaborate on the solar physics goals with the radiation monitor payload. We discuss telescope size, trade-offs of drag-free sensitivities, thermal issues and present an outlook. ASTROD I is a planned interplanetary space mission with multiple goals. The primary aims are: to test General Relativity with an improvement in sensitivity of over 3 orders of magnitude, improving our understanding of gravity and aiding the development of a new quantum gravity theory; to measure key solar system parameters with increased accuracy, advancing solar physics and our knowledge of the solar system; and to measure the time rate of change of the gravitational constant with an order of magnitude improvement and the anomalous Pioneer acceleration, thereby probing dark matter and dark energy gravitationally. It is envisaged as the first in a series of ASTROD missions. ASTROD I will consist of one spacecraft carrying a telescope, four lasers, two event timers and a clock. Two-way, two-wavelength laser pulse ranging will be used between the spacecraft in a solar orbit and deep space laser stations on Earth, to achieve the ASTROD I goals.Comment: 15 pages, 11 figures, 1 table, based on our 2010 proposal submitted for the ESA call for class-M mission proposals, a sequel and an update to previous paper [Experimental Astronomy 23 (2009) 491-527] which was based on our last proposal submitted for the 2007 ESA call, submitted to Experimental Astronom

The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection

Background: Highly pathogenic influenza viruses cause high levels of morbidity, including excessive infiltration of leukocytes into the lungs, high viral loads and a cytokine storm. However, the details of how these pathological features unfold in severe influenza infections remain unclear. Accumulation of Gr1 + CD11b + myeloid cells has been observed in highly pathogenic influenza infections but it is not clear how and why they accumulate in the severely inflamed lung. In this study, we selected this cell population as a target to investigate the extreme inflammatory response during severe influenza infection. Results: We established H1N1 IAV-infected mouse models using three viruses of varying pathogenicity and noted the accumulation of a defined Gr1 + CD11b + myeloid population correlating with the pathogenicity. Herein, we reported that CCR2+ inflammatory monocytes are the major cell compartments in this population. Of note, impaired clearance of the high pathogenicity virus prolonged IFN expression, leading to CCR2+ inflammatory monocytes amplifying their own recruitment via an interferon-alpha/beta receptor 1 (IFNAR1)-triggered chemokine loop. Blockage of IFNAR1-triggered signaling or inhibition of viral replication by Oseltamivir significantly suppresses the expression of CCR2 ligands and reduced the influx of CCR2+ inflammatory monocytes. Furthermore, trafficking of CCR2+ inflammatory monocytes from the bone marrow to the lung was evidenced by a CCR2-dependent chemotaxis. Importantly, leukocyte infiltration, cytokine storm and expression of iNOS were significantly reduced in CCR2-/- mice lacking infiltrating CCR2+ inflammatory monocytes, enhancing the survival of the infected mice. Conclusions: Our results indicated that uncontrolled viral replication leads to excessive production of inflammatory innate immune responses by accumulating CCR2+ inflammatory monocytes, which contribute to the fatal outcomes of high pathogenicity virus infections