Transversality Properties: Primal Sufficient Conditions

The paper studies 'good arrangements' (transversality properties) of collections of sets in a normed vector space near a given point in their intersection. We target primal (metric and slope) characterizations of transversality properties in the nonlinear setting. The Holder case is given a special attention. Our main objective is not formally extending our earlier results from the Holder to a more general nonlinear setting, but rather to develop a general framework for quantitative analysis of transversality properties. The nonlinearity is just a simple setting, which allows us to unify the existing results on the topic. Unlike the well-studied subtransversality property, not many characterizations of the other two important properties: semitransversality and transversality have been known even in the linear case. Quantitative relations between nonlinear transversality properties and the corresponding regularity properties of set-valued mappings as well as nonlinear extensions of the new transversality properties of a set-valued mapping to a set in the range space due to Ioffe are also discussed.Comment: 33 page

About [q]-regularity properties of collections of sets

We examine three primal space local Hoelder type regularity properties of finite collections of sets, namely, [q]-semiregularity, [q]-subregularity, and uniform [q]-regularity as well as their quantitative characterizations. Equivalent metric characterizations of the three mentioned regularity properties as well as a sufficient condition of [q]-subregularity in terms of Frechet normals are established. The relationships between [q]-regularity properties of collections of sets and the corresponding regularity properties of set-valued mappings are discussed.Comment: arXiv admin note: substantial text overlap with arXiv:1309.700

On a nonlinear heat equation associated with Dirichlet -- Robin conditions

This paper is devoted to the study of a nonlinear heat equation associated with Dirichlet-Robin conditions. At first, we use the Faedo -- Galerkin and the compactness method to prove existence and uniqueness results. Next, we consider the properties of solutions. We obtain that if the initial condition is bounded then so is the solution and we also get asymptotic behavior of solutions as. Finally, we give numerical resultsComment: 20 page

An induction theorem and nonlinear regularity models

A general nonlinear regularity model for a set-valued mapping $F:X\times R_+\rightrightarrows Y$, where $X$ and $Y$ are metric spaces, is considered using special iteration procedures, going back to Banach, Schauder, Lusternik and Graves. Namely, we revise the induction theorem from Khanh, J. Math. Anal. Appl., 118 (1986) and employ it to obtain basic estimates for studying regularity/openness properties. We also show that it can serve as a substitution of the Ekeland variational principle when establishing other regularity criteria. Then, we apply the induction theorem and the mentioned estimates to establish criteria for both global and local versions of regularity/openness properties for our model and demonstrate how the definitions and criteria translate into the conventional setting of a set-valued mapping $F:X\rightrightarrows Y$.Comment: 28 page

Integrated signaling pathway and gene expression regulatory model to dissect dynamics of <em>Escherichia coli </em>challenged mammary epithelial cells

AbstractCells transform external stimuli, through the activation of signaling pathways, which in turn activate gene regulatory networks, in gene expression. As more omics data are generated from experiments, eliciting the integrated relationship between the external stimuli, the signaling process in the cell and the subsequent gene expression is a major challenge in systems biology. The complex system of non-linear dynamic protein interactions in signaling pathways and gene networks regulates gene expression.The complexity and non-linear aspects have resulted in the study of the signaling pathway or the gene network regulation in isolation. However, this limits the analysis of the interaction between the two components and the identification of the source of the mechanism differentiating the gene expression profiles. Here, we present a study of a model of the combined signaling pathway and gene network to highlight the importance of integrated modeling.Based on the experimental findings we developed a compartmental model and conducted several simulation experiments. The model simulates the mRNA expression of three different cytokines (RANTES, IL8 and TNFα) regulated by the transcription factor NFκB in mammary epithelial cells challenged with E. coli. The analysis of the gene network regulation identifies a lack of robustness and therefore sensitivity for the transcription factor regulation. However, analysis of the integrated signaling and gene network regulation model reveals distinctly different underlying mechanisms in the signaling pathway responsible for the variation between the three cytokine's mRNA expression levels. Our key findings reveal the importance of integrating the signaling pathway and gene expression dynamics in modeling. Modeling infers valid research questions which need to be verified experimentally and can assist in the design of future biological experiments