Perceptions of shared care among survivors of colorectal cancer from non-English-speaking and English-speaking backgrounds: A qualitative study

Background: Colorectal cancer (CRC) survivors experience difficulty navigating complex care pathways. Sharing care between GPs and specialist services has been proposed to improve health outcomes in cancer survivors following hospital discharge. Culturally and Linguistically Diverse (CALD) groups are known to have poorer outcomes following cancer treatment but little is known about their perceptions of shared care following surgery for CRC. This study aimed to explore how non-English-speaking and English-speaking patients perceive care to be coordinated amongst various health practitioners. Methods: This was a qualitative study using data from face to face semi-structured interviews and one focus group in a culturally diverse area of Sydney with non-English-speaking and English-speaking CRC survivors. Participants were recruited in community settings and were interviewed in English, Spanish or Vietnamese. Interviews were recorded, transcribed, and analysed by researchers fluent in those languages. Data were coded and analysed thematically. Results: Twenty-two CRC survivors participated in the study. Participants from non-English-speaking and English-speaking groups described similar barriers to care, but non-English-speaking participants described additional communication difficulties and perceived discrimination. Non-English-speaking participants relied on family members and bilingual GPs for assistance with communication and care coordination. Factors that influenced the care pathways used by participants and how care was shared between the specialist and GP included patient and practitioner preference, accessibility, complexity of care needs, and requirements for assistance with understanding information and navigating the health system, that were particularly difficult for non-English-speaking CRC survivors. Conclusions: Both non-English-speaking and English-speaking CRC survivors described a blend of specialist-led or GP-led care depending on the complexity of care required, informational needs, and how engaged and accessible they perceived the specialist or GP to be. Findings from this study highlight the role of the bilingual GP in assisting CALD participants to understand information and to navigate their care pathways following CRC surgery

Evaluation of short-term toxicity of ammonia and nitrite on the survival of whiteleg shrimp, Litopenaeus vannamei juveniles

The effects of short-term toxicity of total ammonia nitrogen (TAN) and nitrite were estimated in juveniles of Litopenaeus vannamei under laboratory conditions. In the first experiment, L. vannamei juveniles were exposed to different concentrations of ammonia (0, 5, 10, 15, 20, 30, and 40 mg of TAN L-1) or nitrite (0, 5, 10, 20, 30, 40, and 50 mg of NO2--N L-1), using the static renewal method at a salinity of 20 ppt and pH 8.2. The survival rates of juveniles significantly decreased when exposed to increased concentrations of ammonia or nitrite during the 96 h bioassays. The 24, 48, 72, and 96 h LC50 values of TAN in juveniles were 45.5, 30.1, 13.8, and 6.3 mg L-1, respectively, while the LC50 values of NO2--N at 24, 48, 72, and 96 h were 37.6, 16.7, 8.8, and 4.8 mg L-1, respectively. Experiment 2 evaluated the tolerance of L. vannamei juveniles at various salinities (5, 10, 15, and 20 ppt) under a high concentration of ammonia or nitrite (5 mg L-1). Results showed that the survival rates of L. vannamei at 5 ppt and 10 ppt were significantly lower than those at 20 ppt after 72 h and 96 h of exposure

Systematic risk at the industry level: A case study of Australia

The cornerstone of the capital asset pricing model (CAPM) lies with its beta. The question of whether or not beta is dead has attracted great attention from academics and practitioners in the last 50 years or so, and the debate is still ongoing. Many empirical studies have been conducted to test the validity of beta within the framework of CAPM. However, it is a claim of this paper that beta at the industry level has been largely ignored in the current literature. This study is conducted to examine if beta, proxied for a systematic risk, should be considered valid in the application of the CAPM at the industry level for Australia using daily data on 2200 stocks listed on the Australian Securities Exchange from January 2007 to 31 December 2016. Various portfolio formations are utilized in this paper. General economic conditions such as interest rate, inflation, and GDP are examples of systematic risk. Findings from this study indicate that the selection of portfolio construction, estimation technique, and news about economic conditions significantly affects the view whether or not beta should be considered as a valid measure of systematic risk

Pharmacogenetic variants influence tamoxifen's estrogenic effect on bone density

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109849/1/cptclpt200586.pd

The Structure of TGBC_C Phases

We study the transition from the cholesteric phase to two TGB$_C$ phases near the upper critical twist $k_{c2}$: the Renn-Lubensky TGB$_C$ phase, with layer normal rotating in a plane perpendicular to the pitch axis, and the Bordeaux TGB$_C$ phase, with the layer normal rotating on a cone parallel to the pitch axis. We calculate properties, including order-parameter profiles, of both phases.Comment: 4 pages, 4 figures, Submitted to Physical Review E, Rapid Communications, September 5, 2003; Revised manuscript (to the paper submitted on March 18, 2003, cond-mat/0303365)that includes an important missing reference and presents an improved analysis of a generalized mode

The order of the metal to superconductor transition

We present results from large-scale Monte Carlo simulations on the full Ginzburg-Landau (GL) model, including fluctuations in the amplitude and the phase of the matter-field, as well as fluctuations of the non-compact gauge-field of the theory. {}From this we obtain a precise critical value of the GL parameter \kct separating a first order metal to superconductor transition from a second order one, \kct = (0.76\pm 0.04)/\sqrt{2}. This agrees surprisingly well with earlier analytical results based on a disorder theory of the superconductor to metal transition, where the value \kct=0.798/\sqrt{2} was obtained. To achieve this, we have done careful infinite volume and continuum limit extrapolations. In addition we offer a novel interpretation of \kct, namely that it is also the value separating \typeI and \typeII behaviour.<Comment: Minor corrections, present version accepted for publication in PR

Evaluating use cases for human challenge trials in accelerating SARS-CoV-2 vaccine development

Human challenge trials (HCTs) have been proposed as a means to accelerate SARS-CoV-2 vaccine development. We identify and discuss three potential use cases of HCTs in the current pandemic: evaluating efficacy, converging on correlates of protection, and improving understanding of pathogenesis and the human immune response. We outline the limitations of HCTs and find that HCTs are likely to be most useful for vaccine candidates currently in preclinical stages of development. We conclude that, while currently limited in their application, there are scenarios in which HCTs would be extremely beneficial. Therefore, the option of conducting HCTs to accelerate SARS-CoV-2 vaccine development should be preserved. As HCTs require many months of preparation, we recommend an immediate effort to (1) establish guidelines for HCTs for COVID-19; (2) take the first steps toward HCTs, including preparing challenge virus and making preliminary logistical arrangements; and (3) commit to periodically re-evaluating the utility of HCTs

Market risk analysis of energy in Vietnam

The purpose of this paper is to evaluate and estimate market risk for the ten major industries in Vietnam. The focus of the empirical analysis is on the energy sector, which has been designated as one of the four key industries, together with services, food, and telecommunications, targeted for economic development by the Vietnam Government through to 2020. The oil and gas industry is a separate energy-related major industry, and it is evaluated separately from energy. The data set is from 2009 to 2017, which is decomposed into two distinct sub-periods after the Global Financial Crisis (GFC), namely the immediate post-GFC (2009–2011) period and the normal (2012–2017) period, in order to identify the behavior of market risk for Vietnam’s major industries. For the stock market in Vietnam, the website used in this paper provided complete and detailed data for each stock, as classified by industry. Two widely used approaches to measure and analyze risk are used in the empirical analysis, namely Value-at-Risk (VaR) and Conditional Value-at-Risk (CVaR). The empirical findings indicate that Energy and Pharmaceuticals are the least risky industries, whereas oil and gas and securities have the greatest risk. In general, there is strong empirical evidence that the four key industries display relatively low risk. For public policy, the Vietnam Government’s proactive emphasis on the targeted industries, including energy, to achieve sustainable economic growth and national economic development, seems to be working effectively. This paper presents striking empirical evidence that Vietnam’s industries have substantially improved their economic performance over the full sample, moving from relatively higher levels of market risk in the immediate post-GFC period to a lower risk environment in a normal period several years after the end of the calamitous GFC

Magnetic Order in YBa2_2Cu3_3O6+x_{6+x} Superconductors

Polarized and unpolarized neutron diffraction has been used to search for magnetic order in YBa$_2$Cu$_3$O$_{6+x}$ superconductors. Most of the measurements were made on a high quality crystal of YBa$_2$Cu$_3$O$_{6.6}$. It is shown that this crystal has highly ordered ortho-II chain order, and a sharp superconducting transition. Inelastic scattering measurements display a very clean spin-gap and pseudogap with any intensity at 10 meV being 50 times smaller than the resonance intensity. The crystal shows a complicated magnetic order that appears to have three components. A magnetic phase is found at high temperatures that seems to stem from an impurity with a moment that is in the $a$-$b$ plane, but disordered on the crystal lattice. A second ordering occurs near the pseudogap temperature that has a shorter correlation length than the high temperature phase and a moment direction that is at least partly along the c-axis of the crystal. Its moment direction, temperature dependence, and Bragg intensities suggest that it may stem from orbital ordering of the $d$-density wave (DDW) type. An additional intensity increase occurs below the superconducting transition. The magnetic intensity in these phases does not change noticeably in a 7 Tesla magnetic field aligned approximately along the c-axis. Searches for magnetic order in YBa$_2$Cu$_3$O$_{7}$ show no signal while a small magnetic intensity is found in YBa$_2$Cu$_3$O$_{6.45}$ that is consistent with c-axis directed magnetic order. The results are contrasted with other recent neutron measurements.Comment: 11 pages with 10 figure