Synthesis and molecular structure of dibenzo [4-(α-thienyl- and α-pyrrolyl)pyrido]aza-14-crown-4 ethers

An effective synthesis of dibenzo[4-(heteroaryl)pyrido]aza-14-crown-4 ethers was elaborated by one-step domino condensation of 1,4-bis(2-acetylphenoxy)-3-oxapentane, thiophene- and pyrrolcarbaldehyde and ammonia, in acetic acid. Molecular structure of dibenzo[4-(2-thienyl)pyrido]aza-14-crown-4 ether was established by X-ray analysis. © ISUCT Publishing

The effects of sucrose, silver nitrate, plant growth regulators, and ammonium nitrate on microrhizome induction in perennially-cultivated ginger (Zingiber officinale Roscoe) from Hue, Vietnam

The number of research on ginger microrhizome production is low, despite awareness of the drawbacks to the traditional method of cultivation and the known health benefits associated with ginger essential oils. We examined the effects of several factors on microrhizome induction in order to create a production protocol for the cultivar found in Hue, Vietnam. To determine the optimal conditions for ginger microrhizome production, different concentrations of sucrose, plant growth regulators, ammonium nitrate, and silver nitrate were investigated. Microrhizome fresh weight and diameter were increased to the maximum values with application of BAP (6-benzyl amino purine), NAA (α- naphthaleneacetic acid), IBA (indole-3-butyric acid), and a low ammonium nitrate concentration, with 0.433 g at 9.03 mm, 0.437 g at 9.73 mm, 0.478 g at 10.80 mm, and 0.449 g at 9.53 mm, respectively. Additionally, we demonstrated that kinetin has an inhibitory effect on microrhizome growth. The biggest microrhizomes were grown on MS media containing the optimal concentrations for each factor – 80 g/L sucrose, 1.9 mg/L AgNO3, 550 mg/L ammonium nitrate, 4 mg/L BAP, 6 mg/L NAA, and 4 mg/L IB

Synthesis and molecular structure of dibenzo [4-(α-thienyl- and α-pyrrolyl)pyrido]aza-14-crown-4 ethers

An effective synthesis of dibenzo[4-(heteroaryl)pyrido]aza-14-crown-4 ethers was elaborated by one-step domino condensation of 1,4-bis(2-acetylphenoxy)-3-oxapentane, thiophene- and pyrrolcarbaldehyde and ammonia, in acetic acid. Molecular structure of dibenzo[4-(2-thienyl)pyrido]aza-14-crown-4 ether was established by X-ray analysis. © ISUCT Publishing

Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children’s hospital

Sepsis is a major cause of neonatal mortality and children born in low- and middle-income countries (LMICs) are at greater risk of severe neonatal infections than those in higher-income countries. Despite this disparity, there are limited contemporaneous data linking the clinical features of neonatal sepsis with outcome in LMICs. Here, we aimed to identify factors associated with mortality from neonatal sepsis in Vietnam. We conducted a prospective, observational study to describe the clinical features, laboratory characteristics, and mortality rate of neonatal sepsis at a major children’s hospital in Ho Chi Minh City. All in-patient neonates clinically diagnosed with probable or culture-confirmed sepsis meeting inclusion criteria from January 2017 to June 2018 were enrolled. We performed univariable analysis and logistic regression to identify factors independently associated with mortality. 524 neonates were recruited. Most cases were defined as late-onset neonatal sepsis and were hospital-acquired (91.4% and 73.3%, respectively). The median (IQR) duration of hospital stay was 23 (13–41) days, 344/524 (65.6%) had a positive blood culture (of which 393 non-contaminant organisms were isolated), and 69/524 (13.2%) patients died. Coagulase-negative staphylococci (232/405; 57.3%), Klebsiella spp. (28/405; 6.9%), and Escherichia coli (27/405; 6.7%) were the most isolated organisms. Sclerema (OR = 11.4), leukopenia 4 mmol/L (OR = 3.4), extremely low birth weight (OR = 3.2), and hyperglycaemia >180 mg/dL (OR = 2.6) were all significantly (p<0.05) associated with mortality. The identified risk factors can be adopted as prognostic factors for the diagnosis and treatment of neonatal sepsis and enable early risk stratification and interventions appropriate to reduce neonatal sepsis in LMIC settings